Person: TAKMAZ, TAHA
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Publication Metadata only Evaluation of chronotype and sleep quality in infertile population and comparison with fertile population: a cross-sectional study(2023-12-01) Özçelik C.; VARLI B.; Gökçe A.; Takmaz T.; ÇETİN Ç.; ÖZCAN P.; TAKMAZ, TAHA; ÇETİN, ÇAĞLAR; ÖZCAN, PINARPURPOSE: Infertility is a stressful condition for couples and can affect patients\" circadian rhythm and sleep quality. The goal of this study is to assess differences in chronotype and sleep quality between infertile and fertile people. METHODS: A cross-sectional study was conducted. The infertile patient population consisted study group. Primiparous patients without any known gynecological disease who presented for routine cervical cancer screening follow-up were included in the control group. The Turkish version of the Morningness-Eveningness Questionnaire (MEQ) and Pittsburg Sleep Quality Index (PSQI) scores were evaluated between groups. RESULTS: A total of 227 patients were assessed. There were 110 patients in the study (infertile) group and 117 patients in the control (fertile) group. The evening chronotype proportion (23.6 vs. 0.9%, p < 0.001) was higher in the infertile group. The median of MEQ score was significantly higher in the fertile patients (50, IQR = 43 - 55 vs. 56, IQR = 51 - 59; p < 0.001), and the median of PSQI score was significantly higher in the infertile patients (5, IQR = 4 - 6, vs. 4, IQR = 3 - 5; p < 0.001). CONCLUSIONS: In this study, we found significantly worse sleep quality, and more evening chronotype in the patients with infertility.Publication Open Access Vaginal assisted laparoscopic sacrocervicopexy with anterior colpotomy (VALSAC): technique and mean 20 months outcomes(2020-12-01T00:00:00Z) ŞEVKET, OSMAN; TAKMAZ, TAHA; Sevket, A. C.; TOPRAK, ALİ; ÖZCAN, PINAR; ŞEVKET, OSMAN; TAKMAZ, TAHA; TOPRAK, ALİ; ÖZCAN, PINARThe main purpose of our study is to evaluate the efficacy and safety of vaginal assisted laparoscopic sacrocervicopexy with anterior colpotomy (VALSAC) for apical pelvic organ prolapse. We retrospectively reviewed the results of twenty-three women with stage III and IV prolapse treated with VALSAC between April 2017 and June 2019. With a mean follow-up of 20 months, apical pelvic organ prolapse was cured in 95.7 % of patients. There was no complication in terms of mesh exposure, persistent pain, hematoma, infection. The mean pre- and post-operative POP-Q scores were, for the Aa point, 1.61 +/- 1.82 cm and -1.96 +/- 0.87 cm (p < 0.01), for the C point, 2.87 +/- 1.6 cm and -5.26 +/- 1.86 cm (p < 0.01) for the Ap point, -1.43 +/- 0.89 cm and -2.09 +/- 0.59 cm (p < 0.01). VALSAC is a promising minimally invasive technique for pelvic floor reconstruction that appears to provide good outcomes. Content: The main purpose of our study is to evaluate the efficacy and safety of vaginal assisted laparoscopic sacrocervicopexy with anterior colpotomy (VALSAC) for apical pelvic organ prolapse.Publication Open Access The protective effect of platelet-rich plasma administrated on ovarian function in female rats with Cy-induced ovarian damage(2020-04-01T00:00:00Z) ÖZCAN, Pınar; TAKMAZ, TAHA; Tok, Olgu Enis; Islek, Sevde; Yigit, Esra Nur; Ficicioglu, Cem; ÖZCAN, PINAR; TAKMAZ, TAHAPurpose We evaluated the protective effect of PRP on ovarian function in female rats with cyclophosphamide (Cy)-induced ovarian damage. Methods Thirty-two adult female Sprague-Dawley rats were randomly divided into four groups. Group 1 (control-sodium chloride 0.9%; 1 mL/kg, single-dose ip injection), group 2 (Cy); 75 mg/kg, single-dose ip injection and sodium chloride 0.9% (1 mL/kg, single-dose ip injection), group 3 Cy plus PRP, Cy (75 mg/kg, single-dose and PRP (200 mu l, single-dose) ip injection), group 4 (PRP, 200 mu l, single-dose ip injection). Primordial, antral, and atretic follicle counts; serum anti-Mullerian hormone (AMH) levels; AMH-positive granulosa cells; and gene expression analysis of Ddx4 were assessed. Results Serum AMH levels were significantly lower in group 2 compared to groups 1, 3, and 4 (p < 0.01, p < 0.01, and p = 0.04, respectively). A significant difference was found in the primordial, primary, secondary, antral, and atretic follicle counts between all groups (p < 0.01). There was a statistically significant difference in AMH-positive staining primary, secondary, and antral follicles count between the groups (p < 0.01). There was a statistically significant difference in primary, secondary, and antral AMH positive staining follicle intensity score between the groups (p < 0.01). Ddx4 expression in group 4 was highest compared to other groups. Conclusion Our study may provide evidence that PRP could protect ovarian function against ovarian damage induced by Cy. It could lead to improved primordial, primary, secondary, and antral follicle numbers.Publication Metadata only The predictive value of weight gain and waist circumference for gestational diabetes mellitus(2019-09-01T00:00:00Z) TAKMAZ, TAHA; Yalvac, Ethem Serdar; ÖZCAN, Pınar; Coban, Ulas; Karasu, AYŞE FİLİZ; Unsal, Mehmet; TAKMAZ, TAHA; ÖZCAN, PINAR; GÖKMEN KARASU, AYŞE FİLİZObjective: The first objective of this study was to investigate the relationship between gestational diabetes mellitus (GDM) and gestational weight gain (WG), waist circumference (WC), prepregnancy, and gestational body mass index (BMI). The second aim of our study was to assess the ability of WG, WC, prepregnancy, and gestational BMI with special reference to their cut-off points on predicting the risk of GDM in pregnant women in Turkey.Publication Metadata only Are chronotype and subjective sleep quality associated with preeclampsia and preterm birth?(2020-02-20T04:00:00Z) TAKMAZ, TAHA; Unal, Busra; ÖZCAN, Pınar; ARICI HALICI, BELFİN NUR; Gorchiyeva, Irana; GÖKMEN KARASU, AYŞE FİLİZ; Sahbaz, Cigdem; TAKMAZ, TAHA; ÖZCAN, PINAR; ARICI HALICI, BELFİN NUR; GÖKMEN KARASU, AYŞE FİLİZ; ŞAHBAZ, ÇIĞDEM DILEKThe physiological and physical changes in pregnancy affect the sleep-wake cycle. Limited data exist to evaluate the effect of sleep quality and chronotype during pregnancy on adverse pregnancy outcomes. It is hypothesized that there could be a tendency for the evening chronotype and sleep disturbances to lead to the development of preeclampsia and preterm birth. A total of 313 pregnant women were included. Women were divided into three groups: Group A (control - problem-free), Group B (preeclampsia) and Group C (preterm birth). There were significant differences in the mean PSQI score between the groups (A vs C and A vs B) (p < 0.01). Women in the preterm and the preeclampsia groups reported significantly worse sleep quality. There was a significant difference in the mean MEQ scores between groups (A vs C and A vs B) (p < 0.01). The ratio of the evening-types was significantly higher for the preterm and preeclampsia groups (p < 0.01). Multivariate logistic regression analysis revealed that there is a negative association between preeclampsia/preterm birth and MEQ score, positive association between preeclampsia/preterm birth and PSQI score. Chronotype and sleep quality measurements could provide a simple and feasible way in the prediction of adverse pregnancy outcomes.Publication Metadata only Identification of predictive factors for the probability of pregnancy following ovulation stimulation-intra-uterine insemination cycles in terms of female and male(2021-01-01T00:00:00Z) ÖZCAN, PINAR; TAKMAZ, TAHA; ÖZCAN, PINAR; TAKMAZ, TAHAAim To identify which positive prognostic parameters contribute to successful treatment outcomes and the probability of pregnancy by analyzing the results of infertile couples underwent ovulation stimulation (OS) and intra-uterine insemination (IUI) in our clinic.Publication Metadata only Total Surgical Excision by Ultrasound-Guided Wire Localization for Spontaneous Abdominal-Wall Endometriosis(2019-12-03T00:00:00Z) TAKMAZ, TAHA; KIRAN, Gürkan; ÖZCAN, PINAR; Sahin, NURHAN; Tanoglu, Basak; TAKMAZ, TAHA; KIRAN, GÜRKAN; ÖZCAN, PINAR; ŞAHİN, NURHANBackground: Extrapelvic endometriosis is the most-common form of abdominal-wall endometriosis (AWE). This rare condition usually results from transport of endometrial tissue into incision sites of surgical operations or adjacent tissues. Spontaneous AWE also occurs. A common symptom is a painful and tender mass usually associated with menstruation. Noncyclic pain can occur in 45% of patients. Standard treatment is complete surgical excision. Case: This 44-four-year-old patient, gravida 0, presented with persistent cyclic pain in her right inguinal area, but she had no history of previous abdominal surgery Ultrasonography (USG) showed an obscure, heterogeneous-hypoechogenic mass of similar to 2.0 x 1.5 cm in the right lower quadrant of her abdominal wall. She underwent total surgical excision by ultrasound-guided-wire localization. Results: The nonpalpable mass that was localized via an ultrasound-guided wire was surgically excised. A diagnosis of AWE was confirmed by histopathologic examination of the mass. Two months postoperatively, this patient-s pain disappeared. Conclusions: Extrapelvic endometriosis can be located in almost any organ of the body, including the abdominal wall. The incidence of AWE is reported to be up to 0.03%-3.5%, and most cases of AWE commonly arise in an incision made during a cesarean section. Spontaneous AWE is less common, compared to cesarean-scar endometriosis. The diagnosis of AWE is difficult due to its rarity, subclinical presentation, and generally nonpalpable lesions. Ultrasound-guided-wire localization is a reliable, simple, and practical solution for localizing nonpalpable lesions.Publication Metadata only 2-D and 3-D ultrasonographic characteristics of the ovary in women with PCOS and multifollicular ovaries(2020-10-01T00:00:00Z) Bozkurt, Murat; Kara Bozkurt, Duygu; Kurban, Didem; TAKMAZ, TAHA; ŞEVKET, Osman; ÖZCAN, Pınar; TAKMAZ, TAHA; ŞEVKET, OSMAN; ÖZCAN, PINARIn this prospective study, seventy-six patients (PCOS group; n = 36, multifollicular ovary group; n = 40) were evaluated by 2-D and 3-D ultrasonography. VOCAL programme, echogenicity, number of follicles and blood flow parameters were evaluated. The patients with PCOS had a higher total ovarian volume, mean stromal volume and stromal echogenicity (18.6 +/- 4.75 to 10.2 +/- 3.4p .05). 3 D power Doppler parameters included VI, FI, and VFI values of the patients with PCOS were higher when compared to those of the patients with multifollicular ovary (3.82 +/- 2.65 to 1.78 +/- 1.2,p < .01; 50.76 +/- 4.45 to 40.6 +/- 3.64,p = .03; and 2.34 +/- 1.02 to 1.12 +/- 0.65,p = .02, respectively). Our results revealed that total ovarian volume, stromal volume and echogenicity; VFI, VI, and FI could be useful for differential diagnosis in women with PCOS and multifollicular ovaries.Impact statement What is already known on this subject?Ultrasonography is considered the new diagnostic tool for PCOS. Enlarged ovaries with multiple small follicles peripherally located around increased ovarian stroma with increased stromal echogenicity are the sonographic features of polycystic ovaries. What do the results of this study add?3-D Doppler ultrasonography may be more specific in the determination of multifollicular and polycystic ovaries when compared to RI and PI in 2-D Doppler ultrasonography. Moreover, 3-D power Doppler ultrasonography could be useful for differential diagnosis in women with PCOS and multifollicular ovaries. What are the implications of these findings for clinical practice and/or further research?In clinical practice, the differentiation of multifollicular ovaries and polycystic ovaries (PCO) is difficult with the use of 2-D sonography alone. Therefore, 3-D ultrasound and power Doppler may also be used in addition to 2-D ultrasound for the differentiation of multifollicular ovaries and PCO.Publication Metadata only Does the use of microfluidic sperm sorting for the sperm selection improve in vitro fertilization success rates in male factor infertility?(2020-11-01T00:00:00Z) ÖZCAN, Pınar; TAKMAZ, TAHA; Yazici, Melis Gokce Kocer; Alagoz, Oya Akcin; Yesiladali, Mert; ŞEVKET, Osman; Ficicioglu, Cem; ÖZCAN, PINAR; TAKMAZ, TAHA; ŞEVKET, OSMANAim To evaluate the clinical outcome of assisted reproductive technology (ART) cycles in couple with male infertility, where the spermatozoa were selected using either a conventional gradient-density centrifugation technique or microfluidic sperm sorting.