Person: DEMİR, ESRA
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Publication Metadata only Effect of printing orientation on the fracture strength of additively manufactured 3-unit interim fixed dental prostheses after aging(2022-09-01T00:00:00Z) Diken Turksayar, Almira Ada; Donmez, Mustafa Borga; Olcay, Emin Orkun; Demirel, Münir; DEMİR, ESRA; DEMİR, ESRA© 2022Objectives: To evaluate the effect of printing orientation on the fracture strength of 3-unit interim fixed dental prostheses fabricated by using additive manufacturing and to compare with those fabricated by subtractive manufacturing after thermomechanical aging. Materials and methods: A 3-unit fixed dental prosthesis was designed by using a dental design software (exocad DentalCAD 2.2 Valetta) in standard tessellation language (STL) format. This STL file was exported into a nesting software (PreForm) and 3-unit interim fixed dental prostheses with 5 different orientations (0°, 30°, 45°, 90°, and 150°) were printed by using a 3-dimensional (3D) printing interim resin (Temporary CB) (n = 10). The same STL file was also used to mill polymethymethacrylate (DuoCAD) 3-unit interim fixed dental prostheses as the control group (n = 10). All specimens were cemented onto cobalt-chromium test models representing a maxillary first premolar and first molar tooth with a long-term temporary cement (DentoTemp), and subjected to thermomechanical aging (120,000 cycles, 1.6 Hz, 50 N, 5–55 °C). Then, all specimens were loaded until fracture by using a universal tester. The data were analyzed with nonparametric 1-way analysis of variance (Kruskal-Wallis) and Dunn-s tests (α = 0.05). Results: Additively manufactured specimens printed with 90° showed the lowest fracture strength values (P≤.048). However, the difference between specimens printed with 45° and 90° was nonsignificant (P>.05). Milled 3-unit interim fixed dental prostheses withstood significantly higher loads than 3-unit interim fixed dental prostheses printed with 45° and 150° (P≤.012). In addition, specimens printed with 0° showed higher fracture strength than the specimens printed with 45° (P=.01). Specimens printed with 0° and 30° presented similar fracture strength values with milled (P≥.057) and 150° printed (P>.05) specimens. Conclusions: Printing orientation had a significant effect on the fracture strength of 3-unit interim fixed dental prostheses. Among the additively manufactured samples, those printed with 0° showed similar fracture strength values with the subtractively manufactured samples. Clinical significance: Three-unit interim fixed dental prostheses fabricated with 0° and 30° using the 3D printing interim resin tested may be alternatives to milled PMMA in terms of fracture strength.Publication Metadata only Antioxidant effect of caffeic acid phenethyl ester in experimentally induced periodontitis(2021-08-01T00:00:00Z) Otan Ozden, Feyza; Lutfioglu, Muge; Demir, ESRA; Bilgici, Birsen; DEMİR, ESRAObjectives The aim of the present study was to evaluate the antioxidant effect of systemically administered caffeic acid phenethyl ester (CAPE) in periodontitis. Materials and methods Forty rats were randomly divided into four groups: control, lipopolysaccharide-induced experimental periodontitis (LPS), CAPE 5: LPS+5 mu mol/kg/day CAPE, and CAPE 10: LPS+10 mu mol/kg/day CAPE. Following lipopolysaccharide-induced experimental periodontitis, CAPE was administered intraperitoneally for 28 days. Gingival and serumal total antioxidant status (TAS) and total oxidant status (TOS) were analyzed by enzyme-linked immunosorbent assay (ELISA). Results Gingival tissue TAS was significantly higher with CAPE application compared with the LPS group and was highest in the CAPE 10 group (p0.05). Conclusions The effect of CAPE on increased TAS and decreased TOS levels in inflamed gingival tissue indicates the antioxidant therapeutic potential of CAPE in periodontitis.Publication Metadata only Effect of bisphosphonate as an adjunct treatment for chronic periodontitis on gingival crevicuar fluid levels of nuclear factor-B-K ligand (RANKL) and osteoprotegerin in postmenopausal osteoporosis(2017-03-01T00:00:00Z) Ozden, Feyza O.; Sakallioglu, Elif E.; Demir, ESRA; Bilgici, Birsen; Tuncel, Ozgur K.; Gokosmanoglu, Feyzi; Atmaca, Aysegul; DEMİR, ESRAOsteoporosis and periodontal disease are linked by an altered receptor activator of nuclear factor B-K ligand and osteoprotegerin ratio (RANKL/OPG), and medical treatment with bisphosphonate (BP) may help control these molecules. The effect of BP on clinical findings and gingival crevicular fluid (GCF) values of RANKL and OPG using enzyme-linked immunosorbent assays was evaluated in postmenopausal women; 13 patients with both chronic periodontitis and osteoporosis (group A), 12 systemically healthy patients with chronic periodontitis (group B), 12 periodontally healthy patients with osteoporosis (group C), and 10 systemically and periodontally healthy individuals (group D). Recordings were repeated at the end of months 1, 6, and 12 in groups A, B, and C. At the baseline, groups A and B exhibited the lowest OPG values (P 0.05) or during the observation period (P > 0.008). The use of BP may be effective in preventing periodontal breakdown by controlling the levels of these markers in osteoporosis as an adjunct to periodontal treatment.Publication Metadata only Effects of periodontal and bisphosphonate treatment on the gingival crevicular levels of sclerostin and dickkopf-1 in postmenopausal osteoporosis with and without periodontitis(2022-06-01T00:00:00Z) ÖZDEN, FEYZA OTAN; DEMİR, ESRA; LÜTFİOĞLU, MÜGE; Acarel, Elif Eser; BİLGİCİ, BİRŞEN; ATMACA, AYŞEGÜL; DEMİR, ESRAObjective and Background Both periodontitis and osteoporosis are associated with osteoclast-related bone resorption. Bone metabolism is regulated by wingless-type MMTV integration site family (WNT), and WNT/beta-catenin signals are controlled by physiological antagonists including dickkopf-1 (DKK-1) and sclerostin (SOST). This study examined the effects of periodontal and bisphosphonate (BP) treatment on the gingival crevicular fluid (GCF) sclerostin (SOST) and dickkopf-related protein-1 (DKK-1) levels in osteoporotic and systemically healthy postmenopausal women with and without periodontitis. Materials and Methods A total of 48 postmenopausal women were divided into 4 groups (n = 12) according to periodontal health and osteoporosis status, as follows: Group OP/P: subjects with both osteoporosis and periodontitis; Group P: systemically healthy subjects with periodontitis; Group OP: periodontally healthy subjects with osteoporosis; Group H: systemically and periodontally healthy controls. Clinical data and GCF SOST and DKK-1 levels of the participants were collected at baseline and at 6 and 12 months following the initiation of periodontal and/or BP treatment in the experimental groups. GCF SOST and DKK-1 data were obtained by ELISA. Results Clinical improvements were observed in all experimental groups. GCF SOST and DKK1 baseline levels varied significantly between groups due to periodontal disease (p .05), whereas significant differences were observed between Groups H and P, indicating a deviation from periodontal health in Group P (p < .01). Conclusions Significant changes in GCF SOST and DKK-1 levels were observed among women with osteoporosis who received both periodontal and BP treatment. A more detailed examination of how these treatment protocols can be combined may lead to new therapeutic approaches towards periodontal disease.Publication Metadata only Oroantral Fistula Associated with Destructive Periodontitis.(2016-01-01T00:00:00Z) Özden, Feyza Otan; Özden, Bora; Köse, Ilyas; Demir, Esra; Çelenk, Peruze; DEMİR, ESRAPublication Metadata only Psikososyal Faktörler ve Periodontal Sağlık(2021-12-01T00:00:00Z) Demir, Esra; Karaduman, Burcu; DEMİR, ESRAPublication Metadata only An unusual gingival mass in the anterior maxilla.(2021-06-16T00:00:00Z) Yilmaz, Mustafa; Demir, ESRA; Olgaç, Necat Vakur; DEMİR, ESRAPublication Metadata only Güncel bir irrigasyon solusyonu : MTAD(2013-01-01T00:00:00Z) Demir, Esra; Bodrumlu, Emre; DEMİR, ESRAPublication Metadata only Baseline interleukin-10, CD163 and tumor necrosis factor-like weak inducer of apoptosis gingival tissue levels in relation to clinical periodontal treatment outcomes: A 12-week follow-up study(2022-08-01T00:00:00Z) Yilmaz, Mustafa; DEMİR, ESRA; Gursoy, Mervi; Firatli, Erhan; Gursoy, Ulvi Kahraman; DEMİR, ESRABackground The aim of this study was to examine the relationship between healing response after non-surgical periodontal treatment and baseline gingival tissue levels of M2 macrophage activation-related proteins CD163, interleukin (IL)-10, interferon (IFN)-gamma, and tumor necrosis factor-like weak inducer of apoptosis (TWEAK), and the CD163/TWEAK ratio. Methods Eighty-eight gingival tissue samples from 44 Stage III/IV, Grade C periodontitis patients (18 smokers) and 41 tissue samples from 41 periodontally healthy participants (18 smokers) were evaluated. Clinical parameters were recorded in periodontally healthy individuals at baseline and in periodontitis patients at pre-treatment and 2, 6, and 12 weeks following therapy. IL-10, IFN-gamma, CD163, and TWEAK levels were analyzed with Luminex technique. Results Tissue levels (median, 1(st)-3(rd) quartile) of IL-10 (pg/ng protein), CD163 (pg/mu g protein) and TWEAK (pg/mu g protein) were as follows: IL-10 periodontitis: 2.08, 0.86-5.32 and periodontally healthy: 5.22, 3.20-10.25; CD163 periodontitis: 8.85, 4.92-14.06 and periodontally healthy: 18.36, 12.51-34.02; TWEAK periodontitis: 0.08, 0.05-0.11 and periodontally healthy: 0.16, 0.12-0.21. IL-10, CD163, and TWEAK levels were higher (P < 0.001) in periodontally healthy tissues than in periodontitis tissues. Pocket closure at 12 weeks was associated with elevated baseline gingival CD163 levels (P = 0.047) and CD163/TWEAK ratio (P = 0.001). Elevated baseline gingival CD163/TWEAK ratio was associated with pocket reduction at 6 (P = 0.022) and 12 weeks (P = 0.002). Conclusion Associations of pocket closure with pre-treatment gingival tissue CD163 levels and CD163/TWEAK ratio indicate that baseline M2 macrophage activation profile may play a role in periodontal wound healing.