Person: BAŞARANOĞLU, METİN
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Publication Rate and Predictors of Endoscopic Mucosal Healing in Biologic Naive Patients with Inflammatory Bowel Disease by Azathioprine Treatment: A Real World, 10 Years- Experience from a Single Centre in Turkey.(2016-08-01T00:00:00Z) Basaranoglu, METİN; Ertan, A; Mathew, S; Senturk, H; Ala, A; Demirbag, AE; BAŞARANOĞLU, METİN; ŞENTÜRK, HAKANBackground: There is increasing evidence that endoscopic mucosal healing (EMH) is a key target in inflammatory bowel disease (IBD) therapy. However, there is limited evidence of EMH rates with conventional IBD therapy outside of Western population groups. Ai̇m: To evaluate the role of azathioprine (AZA) in inducing EMH in IBD patients. Methods: Patients with inflammatory bowel disease were evaluated in terms of endoscopic mucosal healing and the incidence of surgical interventions during the azathioprine treatment between 1995 to 2014. Results: A total of 120 inflammatory bowel disease patients were enrolled. Endoscopic mucosal healing was found in 37% patients with inflammatory bowel disease (42% in chronic ulcerative colitis and 33% in Crohn's disease). Male gender had a negative impact on the efficacy of azathioprine (P<0.05). Responder inflammatory bowel disease patients were older (age at the IBD diagnose) than the nonresponder (P<0.05). Azathioprine therapy reduced the number of the surgical interventions (P<0.05). Conclusi̇on: We showed that azathioprine therapy significantly induced endoscopic mucosal healing in biologic naïve patients with active inflammatory bowel disease as well as decreasing the surgical interventions, with negative predictive factors identified by a younger age at IBD presentation and male gender.Publication Mallory-Denk bodies: Correlation with steatosis, severity, zonal distribution, and identification with ubiquitin(2015-11-01T00:00:00Z) KAYACETIN, Serra; Basaranoglu, METİN; BAŞARANOĞLU, METİNBackground/Aims: Intermediate filament proteins contain few aggregates as their main component. Among those, Mallory-Denk bodies (MDBs) are by far the best recognized component. To identify the presence of MDBs in individuals having chronic liver disease and to evaluate the correlation among MDBs and steatosis as well as the severity and zonal distribution of hepatocyte balloon degeneration. Tertiary reference hospital.Publication Karaciğerimizi fruktoz şurubundan neden korumalıyız? YAĞLI KARACİĞER & ŞİŞMAN SİROZU(2017-11-01T00:00:00Z) Başaranoğlu, Metin; BAŞARANOĞLU, METİNPublication Ovaries are more vulnerable than hepatocytes for insulin resistance and hyperinsulinemia(2016-01-01) GULTEPE, Ilhami; Basaranoglu, METİN; SULEYMANOGLU, Yaser; Basaranoglu, GÖKÇEN; BEYAZIT, Fatma; BAŞARANOĞLU, METİN; BAŞARANOĞLU, GÖKÇENBackground/Aims: Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are common metabolic disorders. We aimed to evaluate the underlying mechanisms in the development of NAFLD and PCOS.Publication Role of Discipline and Educational Method on Vocational High School Students- Success in an Anesthesia Course(2015-04-01) Basaranoglu, GÖKÇEN; Basaranoglu, METİN; BAŞARANOĞLU, GÖKÇEN; BAŞARANOĞLU, METİNObjective: The goal of this study is to reveal the relationship between discipline and teaching method and between vocational high school technical students' success in an anesthesia course and levels of following the lessons. Methods: A questionnaire was filled out by first-year technical students in an anesthesia course for situational awareness evaluation at the beginning of the term. Oral presentations were supported by catechetics, reward systems, etc. to ensure active participation. Results: While the students' success rate was 91.9%, the dissatisfaction rate was 4%. The students stated that they were most satisfied (100%) with the rewarding part of the theoretical lessons. Conclusion: Anesthesiology requires discipline for achieving success. Students' course success on anesthesia can be enhanced using a student-centered learning and reward system.Publication PORTAL VEIN THROMBOSIS(2022-04-01T00:00:00Z) Başaranoğlu, Metin; BAŞARANOĞLU, METİNPublication Pathophysiology of insulin resistance and steatosis in patients with chronic viral hepatitis(2011-09-28) Basaranoglu, METİN; Basaranoglu, GÖKÇEN; BAŞARANOĞLU, METİN; BAŞARANOĞLU, GÖKÇENChronic hepatitis due to any cause leads to cirrhosis and end-stage liver disease. A growing body of literature has also shown that fatty liver due to overweight or obesity is a leading cause of cirrhosis. Due to the obesity epidemic, fatty liver is now a significant problem in clinical practice. Steatosis has an impact on the acceleration of liver damage in patients with chronic hepatitis due to other causes. An association between hepatitis C virus (HCV) infection, steatosis and the onset of insulin resistance has been reported. Insulin resistance is one of the leading factors for severe fibrosis in chronic HCV infections. Moreover, hyperinsulinemia has a deleterious effect on the management of chronic HCV. Response to therapy is increased by decreasing insulin resistance by weight loss or the use of thiazoli-denediones or metfornnin. The underlying mechanisms of this complex interaction are not fully understood. A direct cytopathic effect of HCV has been suggested. The genomic structure of HCV (suggesting that some viral sequences are involved in the intracellular accumulation of triglycerides), lipid metabolism, the molecular links between the HCV core protein and lipid droplets (the core protein of HCV and its transcriptional regulatory function which induce a triglyceride accumulation in hepatocytes) and increased neolipogenesis and inhibited fatty acid degradation in mitochondria have been investigated. (C) 2011 Baishideng. All rights reserved.Publication Dietary trans-fatty acid induced NASH is normalized following loss of trans-fatty acids from hepatic lipid pools.(2012-10-01T00:00:00Z) Neuschwander-Tetri, BA; Ford, DA; Acharya, S; Gilkey, G; Basaranoglu, METİN; Tetri, LH; Brunt, EM; BAŞARANOĞLU, METİNPublication Whether the existence of fat in the liver increases the risk of cancer and operation in patients and in their relatives(2012-10-01T00:00:00Z) BAŞARANOĞLU, METİN; Canbakan, Billur; Yildiz, Kemal; Ceylan, Bahadir; Baysal, Birol; ŞENTÜRK, HAKAN; BAŞARANOĞLU, METİN; ŞENTÜRK, HAKANPublication Two cases with Plummer-Vinson syndrome in the 21st century(2016-01-01) GULTEPE, Ilhami; Basaranoglu, METİN; BAŞARANOĞLU, METİNPlummer-Vinson syndrome (PVS) is characterized by the presence of postcricoid dysphagia, iron deficiency anemia, and upper esophageal web. This syndrome is now a rare condition because of the improvement in nutritional status and increased awareness regarding iron deficiency anemia and the early diagnosis and easy treatment of this anemia or underlying causes. In this presentation, we report two middle-aged female patients with PVS and briefly review the literature.