Person: ÜNVER, NURCAN
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NURCAN
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ÜNVER
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Publication Metadata only Relationship between the poor glycemic control and risk factors, life style and complications.(2017-01-01T00:00:00Z) KAYAR, Yusuf; ILHAN, Aysegul; KAYAR, Nuket Bayram; Unver, NURCAN; Coban, GANİME; EKINCI, Iskender; HAMDARD, Jamsid; PAMUKCU, Ozgul; EROGLU, Hatice; ÜNVER, NURCAN; ÇOBAN, GANİMEIt has shown that the decrease of blood glucose levels in patient with diabetes mellitus decreases mortality and morbidity rates. Main purpose in diabetes is to achieve and prevent the glycemic control. We aimed to evaluate the relationship between poor glycemic control and metabolic parameters, individual life and complications. Seven hundred fifty seven patients with type II diabetes mellitus have evaluated with demographical characteristic, body mass index, abdominal circumferences, blood pressures, dietary compliances, physical exercise statuses and laboratory analysis; and the relationship of these parameteres were investigated. Poor glycemic control was found significantly associated with duration of diabetes, age of onset, family history, job status, educational status, antidiabetic drugs, body mass index, abdominal circumference, hypertension, lipid and fasting plasma glucose levels. There was a significant relationship between the glycemic control and dietary compliance, physical activity, self blood glucose monitoring and drug compliance. While there is a significant relationship between the poor glycemic control and nephropathy, retinopathy, neuropathy and cardiovascular diseases; no significant relationship was seen in the cerebrovascular diseases and arthropathy. We have pointed the relationship of glycemic control with sociodemographic, medical status, life style, lipid levels and complications. Better results can be obtained by eliminating the factors related to poor glycemic control.Publication Metadata only Unusual Histopathological Findings in Appendectomy Specimens: A Retrospective Analysis of 2047 Cases.(2019-04-01) UNVER, NURCAN; COBAN, GANİME; ARıCı, DİLEK SEMA; BUYUKPıNARBASıLı, NUR; Gucin, ZÜHAL; MALYA, FATMA ÜMİT; ONARAN, OI; TOPALAN, K; ÜNVER, NURCAN; ÇOBAN, GANİME; ARICI, DILEK SEMA; BÜYÜKPINARBAŞILI, NUR; GÜCİN, ZÜHAL; MALYA, FATMA ÜMİTPublication Open Access Co-existence of acute appendicitis and inflammatory myofibroblastic tumor of the small intestine: A case report(2015-09-01) Unver, NURCAN; Coban, GANİME; ONARAN, Oyku Izel; ARSLAN, ADNAN; Malya, FATMA ÜMİT; HASBAHCECI, Mustafa; ÜNVER, NURCAN; ÇOBAN, GANİME; KUNDUZ, ENVER; ARSLAN, ADNAN; MALYA, FATMA ÜMİTIntroduction: Inflammatory myofibroblastic tumor as a rare neoplastic lesion is seen most commonly in the pulmonary system. Beside the presence of limited number of inflammatory myofibroblastic tumors of the gastrointestinal tract in the literature, co-existence with acute appendicitis has not been reported before. Presentation of case: A 27-year-old woman admitted to emergency department with acute abdominal pain at the right lower quadrant. The initial diagnosis was as acute appendicitis. Intraoperatively, a mass with a diameter of almost 5 cm originated from the distal ileal segments neighboring the appendix was seen. The patient was managed by segmental resection of the small intestine including the mass with appendectomy. Histologically, there were bundles of spindle cells accompanied by lymphoplasmocytic infiltration. The immunohistochemical studies showed that tumor cells were positive for smooth muscle actin, vimentin, perinuclear activity for anaplastic lymphoma kinase and CD 68. The final pathologic diagnosis was inflammatory myofibroblastic tumor. Discussion: Concomitant resection of tumoral lesions detected in the neighbor intestinal segments during appendectomy should be considered to diagnose and treat. For the diagnosis of inflammatory myofibroblastic tumor, immunohistochemistry pattern including positivity for actin, vimentin, CD 68 and anaplastic lymphoma kinase plays a crucial role. Therefore, detailed immunohistochemistry analysis should be performed in suspicious cases. Conclusion: Coexistence of inflammatory myofibroblastic tumor located in the gastrointestinal system with acute appendicitis is a rare event. Complete surgical excision should be regarded as the mainstay of the treatment. Long-term follow up with serial imaging techniques is recommended.Publication Metadata only Biphasic malignant mesothelioma of the testis: Case report.(2017-03-01) ARMAĞAN, ABDULLAH; ÇOBAN, GANİME; ÜNVER, NURCAN; KIZILTAN, HURİYE ŞENAY; GÜCİN, ZÜHAL; ÇOBAN, GANİME; ÜNVER, NURCAN; KIZILTAN, HURİYE ŞENAYPublication Metadata only Evaluation of solid pseudopapillary tumor of the pancreas: One tertiary center experience(2018-01-01) KAYAR, Yusuf; Unver, NURCAN; ÇOBAN, GANİME; GÜCİN, ZÜHAL; EKINCI, Iskender; EMEGIL, Sebnem; KAYAR, Nuket Bayram; BAYSAL, Birol; BUGDACI, Mehmet Sait; ŞENTÜRK, HAKAN; ÜNVER, NURCAN; ÇOBAN, GANİME; GÜCİN, ZÜHAL; ŞENTÜRK, HAKANPublication Open Access Renal Hydatid Cyst(2016-04-01) Coban, GANİME; Orhan, ZEYNALABİDİN; Kalkan, SENAD; TUZUN, Umit; Unver, NURCAN; ÇOBAN, GANİME; ORHAN, ZEYNALABIDIN; KALKAN, SENAD; ÜNVER, NURCANThe larval form of Echinococcus granulosus (tapeworm), which causes hydatid cysts, penetrates the intestinal mucosa and settles in tissues and is contracted through animal contact or other ways. The most common location is liver, and renal involvement is very rare. It is usually diagnosed with nonspecific symptoms or incidentally. A kidney lesion was incidentally detected in a 55-year-old female patient who was suffering from chronic diseases and underwent partially nephrectomy. We aim to present this case in which renal hydatid cyst was diagnosed with the help of literature because of its rarity.Publication Open Access Use of serum and peritoneal CEA and CA19-9 in prediction of peritoneal dissemination and survival of gastric adenocarcinoma patients: are they prognostic factors?(2018-04-01) HASBAHCECI, MUSTAFA; Malya, FATMA ÜMİT; Kunduz, ENVER; Guzel, MEHMET; Unver, NURCAN; Akcakaya, ADEM; MALYA, FATMA ÜMİT; KUNDUZ, ENVER; GÜZEL, MEHMET; ÜNVER, NURCAN; AKÇAKAYA, ADEMINTRODUCTION To evaluate the impact of serum and peritoneal levels of tumour markers on peritoneal carcinomatosis and survival in gastric adenocarcinoma. MATERIALS AND METHODS Patients with gastric adenocarcinoma were evaluated with regard to serum and peritoneal carcinoembryonic antigen (CEA) and CA19-9. Numeric values and groupings based on serum and peritoneal cutoff values were used. Development of peritoneal carcinomatosis, including positive washing cytology, was regarded as main outcome. Gastric cancer outcomes as disease free and overall survival were analysed. RESULTS There were 67 patients with a mean age of 60 ± 11 years. Positive peritoneal washing cytology was significantly associated with serum CA19-9 and high serum CA 19–9 group (P = 0.033 and P = 0.011, respectively). High peritoneal CEA was shown to be significantly associated with peritoneal carcinomatosis (P = 0.032). After a median follow up of 17 months, 48 patients (71.7%) were alive. Patients with peritoneal carcinomatosis showed significant poorer prognosis as shown by overall survival rate of 28.6%. Only serum CEA was significantly associated with lower disease free and overall survival (P = 0.002 and P = 0.001, respectively). DISCUSSION AND CONCLUSION Serum CEA is shown to be significantly associated with poor prognosis for gastric cancer patients. Serum level of CA19-9 and high peritoneal CEA levels are significant predictors for positive peritoneal washing cytology and the development of peritoneal carcinomatosis, respectively. Therefore, the possible impact of serum and peritoneal tumor markers especially on the staging and prognosis of gastric cancer remains to be clarified by future studies.Publication Metadata only Peri-operative radiotherapy for the prevention of post -operative fibrosis on rats(2018-10-01) KIZILTAN, HURİYE ŞENAY; ERIS, ALİ HİKMET; MERAL, İSMAİL; SEYİTHANOĞLU, HAKAN; DÜNDAR, TOLGA TURAN; EREN, FATMA; ÜNVER, NURCAN; AYDIN, TEOMAN; MAYADAGLı, ALPASLAN; KIZILTAN, HURİYE ŞENAY; ERİŞ, ALİ HİKMET; MERAL, İSMAİL; SEYİTHANOĞLU, MEHMET HAKAN; DÜNDAR, TOLGA TURAN; ÜNVER, NURCAN; AYDIN, TEOMAN; MAYADAĞLI, ALPASLANBackground: Post-operative fibrosis related pains and functional anomalies can be serious problems for patients. Radiotherapy (RT) could inhibit fibrosis which may occurs post- operation especially following laminectomy. Therefore, this study was designed to investigate the effect of peri-operative RT on the prevention of post-operative fibrosis and scar formation on rats. Materials and Methods: Twenty three male Wistar albino rats, were divided into three experimental groups. Laminectomy was performed to L3 and L4 lomber vertebral regions of group L and L+R rats. The rats in L+R group in addition to this procedure also received ped-operative RT on the laminectomy area. A total dose of 700 cGy of RT was applied as a single fraction using electrons. Control rats received no treatment. A rotarod test was performed at 20, 30 and 40 rpm/min speed rates to determine the physical performances of the rats. Results: The results have indicated statistically significant (P<0.05) differences for the 30 rpm/min rotarod test between the L and L+R groups. Histopatologically, significant differences were observed in epidural fibrosis, fibroblast cell density and arachnoid adhesion between the L and L+R groups. Conclusion: It was concluded that ped-operative RT may provide a significant advantage for prevention post-laminectomic of scar tissue formation.Publication Metadata only Spinal cord ischemia after endoscopic ultrasound guided celiac plexus neurolysis: case report and review of the literature(2017-01-01) Koker, Ibrahim Hakki; Aralasmak, AYŞE; Unver, NURCAN; Asil, TALİP; Senturk, HAKAN; KÖKER, İBRAHİM HAKKI; ARALAŞMAK, AYŞE; ÜNVER, NURCAN; ASİL, TALIP; ŞENTÜRK, HAKANIntroduction: Endosonography guided celiac plexus neurolysis is efficacious in the management of severe pain due to advanced pancreatic cancer. Although endoscopic ultrasound (EUS) guided celiac neurolysis (CN) is mostly a safer procedure than the percutaneous posterior approach, severe complications such as paraplegia have been reported.Publication Metadata only Clinical evaluation of simultaneous integrated boost in brain metastasis patients with helical intensity modulated radiotherapy(2018-04-01) KIZILTAN, HURİYE ŞENAY; ERIS, A.H.; MERAL, İSMAİL; SEYITHANOGLU, H.; DÜNDAR, TOLGA TURAN; EREN, F.; UNVER, NURCAN; AYDIN, TEOMAN; MAYADAĞLI, ALPASLAN; BAYIR, A.G.; CELIKTEN, M.; KIZILTAN, HURİYE ŞENAY; MERAL, İSMAİL; DÜNDAR, TOLGA TURAN; TEKÇE, ERTUĞRUL; ÜNVER, NURCAN; AYDIN, TEOMAN; MAYADAĞLI, ALPASLANBackground: This study was performed to assess patient survival and treatment toxicity after helical tomotherapy (HT) with simultaneous integrated boost (SIB) radiotherapy (RT) for cancer patients with one to eight brain metastases (BM) who have been treated with or without surgery. Materials and Methods: A total of 48 brain metastasis (BM) patients were included in this retrospective study between April 2015 and December 2016,. The patients were treated with image-guided intensity modulated radiation therapy (IMRT) on the helical tomotherapy (HT) machine. Whole brain HT as 25 Gy and SIB to metastasis sites as 35 Gy was delivered in 10 fractions. The patient were aged between 50 to 80 years old, volume of the BM was between 6 to 75 cc and the number of brain metastasis was between 1 to 8, Karnofsky Performance Score (KPS) ranged between 50-90 and RPA I-III. Surgery was performed to two patients before RT. The maximum patient follow-up time was 20 months. Results: The primary neurotoxicity observed in patients was grade I- II brain edema related headache and lethargy. In patients who had survived 3- 12 months, KPS improved median score of 20 points and RPA was grade I after six months. Twelve patients had passed away at the end of a 20- month follow-up. Conclusion: HT utilizing SIB treatment for 1- 8 BM was achieved successfully with no significant toxicity. An improvement of performance status indicators of patients following RT was observed.