Person: ÖZEK, ERDİNÇ
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Publication Metadata only A Simple Technique for Bone Storage after Decompressive Craniectomy in Children(2014-01-01T00:00:00Z) Silav, Gokalp; Bolukbasi, Fatih Han; Ozek, ERDİNÇ; Tonge, Mehmet; Onoz, Mustafa; ELMACI, ILHAN; ÖZEK, ERDİNÇCranial vault reconstruction in the pediatric population is a specialized procedure, which requires additional considerations. Generally, inherent difficulties of bone storage and cranioplasty are neglected in the literature. We present a simple method of bone storage and autologous cranioplasty in a small child with severe head injury. The child underwent surgical treatment with decompressive craniectomy. A bone flap was transversally divided into two pieces and stored under the galea. Bone storage and reconstruction of the cranial vault with our surgical technique is a safe, easy and cost-effective choice excluding the surgical trauma to obtain a new subcutanous pocket for bone storage in pediatric decompressive craniectomy patients. (C) 2015 S. Karger AG, BaselPublication Metadata only En Plaque Pituitary Adenoma within a Rathke-s Cleft Cyst: Report of Three Cases(2018-01-01T00:00:00Z) Latifaci, Ismail; Iplikcioglu, Celal; Tokmak, Mehmet; ÖZEK, ERDİNÇ; ÖZEK, ERDİNÇConcomitant pituitary adenomas and Rathke-s cleft cysts (RCCs) are rare. These coexisting lesions are difficult to diagnose preoperatively due to their variable signal intensity on magnetic resonance imaging (MRI) and position of the RCC. We describe three cases of coexisting pituitary adenoma and RCC, and review the relevant literature. In our cases, the RCCs were relatively large and the en plaque adenomas appeared as enhanced cyst walls on MRI examination. We also report the clinical, radiologic, surgical, and histopathologic findings of each case.Publication Metadata only Comparison of TOF MRA, Contrast-Enhanced MRA and Subtracted CTA from CTP in Residue Evaluation of Treated Intracranial Aneurysms(2018-01-01) Dundar, TOLGA TURAN; Kits, Serkan; Ozdemir, HÜSEYİN; Seyithanoglu, MEHMET HAKAN; Uysal, Omer; Toprak, HÜSEYİN; Ozek, ERDİNÇ; Alkan, ALPAY; DÜNDAR, TOLGA TURAN; ARALAŞMAK, AYŞE; ÖZDEMİR, HÜSEYIN; SEYİTHANOĞLU, MEHMET HAKAN; UYSAL, ÖMER; TOPRAK, HÜSEYİN; KİTİŞ, SERKAN; ÖZEK, ERDİNÇ; ALKAN, ALPAYAIM: To compare effectiveness of contrast-enhanced magnetic resonance angiography (CE-MRA), 3D-Time-of-flight magnetic resonance angiography (3D-TOF-MRA) and subtracted computed tomography angiography from computed tomography perfusion (sub-CTA) in residue evaluation of intracranial aneurysms treated either with coiling or clipping.Publication Metadata only Pineal Epidermoid Tumors: Report of Five Cases(2013-07-01T00:00:00Z) Dinc, Cem; Iplikcioglu, Ahmet Celal; Ozek, ERDİNÇ; ÖZEK, ERDİNÇAIM: The aim of this study was to retrospectively analyse the clinical, radiological features and surgical outcome of pineal epidermoid tumors treated at a single neurosurgical department.Publication Metadata only Spinal Extradural Arachnoid Cysts: A Series of 10 Cases(2015-09-01T00:00:00Z) Tokmak, Mehmet; Ozek, ERDİNÇ; Iplikcioglu, Ahmet Celal; ÖZEK, ERDİNÇBackground and ObjectiveSpinal arachnoid cysts are rare lesions, accounting for only 1% of all primary spinal mass lesions. They can occur in extradural, intradural, or intramedullary locations. The extradural cysts are thought to arise from defects in the dura mater through which the arachnoid herniates. This report presents 10 cases of spinal extradural arachnoid cysts and discusses our diagnostic and therapeutic approach to this rare clinical entity.Publication Metadata only Spinal Multiple Extradural Arachnoid Cysts: Became Symptomatic in An Elderly Age; A Case Report(2012-01-01T00:00:00Z) Iplikcioglu, Celal; Ozek, ERDİNÇ; ÖZEK, ERDİNÇSpinal extradural arachnoid cyst is a rare disease that includes approximately 1% of all primary spinal lesions. Spinal arachnoid cysts most frequently occur in thoracic region as a solitary mass. However, multiple extradural arachnoid cysts are extremely rare pathologies and only 8 cases have been reported in the literature before. In this report we described a case of 66 year old woman who had multiple spinal extradural arachnoid cysts presented with paraparesis and became symptomatic in an elderly age.Publication Metadata only Beyin Tümörü Kök Hücresi(2018-10-01T00:00:00Z) Dündar, Tolga Turan; Kitiş, Serkan; Gundag, Meliha; Özek, Erdinç; Abdallah, Anas; Seyithanoğlu, Mehmet Hakan; Çetin, Güven; DÜNDAR, TOLGA TURAN; KİTİŞ, SERKAN; GUNDAG, MELİHA; ÖZEK, ERDİNÇ; SEYİTHANOĞLU, MEHMET HAKAN; ÇETİN, GÜVENPublication Open Access Frameless Neuronavigation Assisted Brain Biopsy: Safety, Efficiency and Our Experience(2019-03-01T00:00:00Z) SEYİTHANOĞLU, MEHMET HAKAN; ÖZEK, ERDİNÇ; SEYİTHANOĞLU, MEHMET HAKAN; KİTİŞ, SERKAN; DÜNDAR, TOLGA TURAN; TEKİN, ABDURRAHIM; HATİBOĞLU, MUSTAFA AZİZPublication Metadata only Matrix metalloprotease-9 expresssion in meningioma: Correlation with growth fraction and role of gender. A pilot immunohistochemical study(2018-09-01T00:00:00Z) ÖZEK, ERDİNÇ; Ozcan, Deniz; Celik, Suat Erol; Iplikcioglu, Ahmet Celal; ÖZEK, ERDİNÇObjective: Matrix metalloproteases (MMPs), particularly MMP2 and MMP9 increase tumor invasion and edema in meningiomas. Although lesser recognized, MMPs may also enhance cell growth via liberating growth factors or via cleaving inactive growth factors into active isoforms. However, there exist very few studies, which investigated correlation of MMPs with growth fraction in meningiomas. Meningiomas are seen more frequently in women and their growth accelarate during pregnancy. However, no study examined whether MMP-expressions in meningioma differ with gender.Publication Metadata only Gamma knife radiosurgery compared to whole brain radiation therapy enhances immunity via immunoregulatory molecules in patients with metastatic brain tumours.(2019-07-18) Hatiboglu, MA; Kocyigit, A; Guler, Eray Metin; Nalli, A; Akdur, K; Sakarcan, A; Mayadagli, A; Uysal, O; HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; ÖZEK, ERDİNÇ; UYSAL, ÖMER; MAYADAĞLI, ALPASLANBackground: There is lack of data on the effect of stereotactic radiosurgery in modulation of the immune system for cancer patients with metastatic brain tumours. Therefore, we investigated the change in levels of immunoregulatory molecules after Gamma Knife radiosurgery (GKR) and whole brain radiation therapy (WBRT) in patients with brain metastases. Methods: Peripheral blood samples were collected from 15 patients who received GKR, nine patients who received WBRT for brain metastases and 10 healthy controls. Samples were obtained at three time points such as before, 1h after and 1 week after the index procedure for patients treated with GKR or WBRT. All patients- demographic data and radiosurgical parameters were retrospectively reviewed. We analyzed the change in the levels of T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death ligand-1 (PD-L1), and cytokines such as IL-2, IL-10, IFN-gamma, TNF-alpha after GKR and WBRT using Enzyme-linked immunosorbent assays (ELISA). Results: Baseline level of IFN-gamma was found to be lower and that of PD-L1 was higher in the GKR group compared to WBRT group and healthy controls (p < 0.05 and p < 0.01, respectively). Levels of IFN-gamma and IL-2 were increased (p < 0.01 and p < 0.01, respectively), while CTLA-4 and PD-L1 were decreased (p = 0.05 and p = 0.01, respectively) after GKR compared to pre-GKR levels, while there was no change after WBRT. Conclusion: GKR regulates immunoregulatory molecules towards enhancing the immune system, while WBRT did not exert any effect. These findings suggested that treatment of metastatic brain lesion with GKR might stimulate a systemic immune response against the tumour.