Person: KURTULMUŞ, AYŞE
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Publication Reduced regulatory T cells with increased proinflammatory response in patients with schizophrenia(2020-06-01T00:00:00Z) Sahbaz, Cigdem; Zibandey, Noushin; KURTULMUŞ, AYŞE; Duran, Yazgul; Gokalp, Muazzez; KIRPINAR, İSMET; ŞAHİN, FİKRETTİN; Guloksuz, Sinan; AKKOÇ, TUNÇ; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞE; KIRPINAR, İSMETAim To investigate whether circulating T cells including regulatory T cells (Treg) and derived cytokines contribute to the immune imbalance observed in schizophrenia. Methods Forty patients with schizophrenia and 40 age, sex, body mass index, education, and smoking status-matched healthy controls (HC) are included in the study. We stained cells with anti-CD14, anti-CD3, anti-CD4, anti-CD8, anti-CD19, anti-CD20, and anti-CD16/56. Peripheral blood mononuclear cells (PBMCs) were isolated and stained with the human FoxP3 kit containing anti-CD4/anti-CD25 and intracellular anti-Foxp3. PBMCs were cultured for 72 h and stimulated with anti-CD3/anti-CD28. Cytokines (IL-2, IL-4, IL-6, IL-10, IFN-gamma, TNF-alpha, and IL-17A) were measured from the culture supernatant and plasma using the Th1/Th2/Th17 cytokine bead array kit. Results In comparison with HC, Treg percentages in schizophrenia were higher (1.17 +/- 0.63 vs 0.81 +/- 0.53, P = 0.005) in unstimulated but lower in the stimulated condition (0.73 +/- 0.69 vs 0.97 +/- 0.55, P = 0.011). Activated T cell percentages were higher in schizophrenia than HC in unstimulated (2.22 +/- 0.78 vs 1.64 +/- 0.89, P = 0.001) and stimulated (2.25 +/- 1.01 vs 1.72 +/- 1.00, P = 0.010) conditions. The culture supernatant levels of IL-6 (7505.17 +/- 5170.07 vs 1787.81 +/- 1363.32, P < 0.001), IL-17A (191.73 +/- 212.49 vs 46.43 +/- 23.99, P < 0.001), TNF-alpha (1557 +/- 1059.69 vs 426.57 +/- 174.62, P = 0.023), and IFN-gamma (3204.13 +/- 1397.06 vs 447.79 +/- 270.13, P < 0.001); and plasma levels of IL-6 (3.83 +/- 3.41vs 1.89 +/- 1.14, P = 0.003) and IL-17A (1.20 +/- 0.84 vs 0.83 +/- 0.53, P = 0.033) were higher in patients with schizophrenia than HC. Conclusion Our explorative study shows reduced level of Foxp3 expressing Treg in a stimulated condition with induced levels of proinflammatory cytokines in patients with schizophrenia.Publication Eating disorders in patients with irritable bowel syndrome(2020-12-01T00:00:00Z) Kayar, Yusuf; Agin, Mehmet; Dertli, Ramazan; Kurtulmus, Ayse; Boyraz, Rabia Keyser; Onur, Nafiye Selcan; KIRPINAR, İSMET; KURTULMUŞ, AYŞE; ÖNÜR, NAFIYE SELCAN; KIRPINAR, İSMETIntroduction: Eating disorders (ED) constitute an important group of conditions that commonly occur in adolescents. Gastrointestinal complaints are frequently reported in ED patients. Few studies assessed the association of irritable bowel syndrome (IBS) with ED. The aim of the current study is to determine the prevalence of ED in a group of IBS patients and compare it with a healthy control group and assess the relationship of IBS sub-types, it-s duration and severity with ED.Publication Association between emotional functioning and biological rhythm disruptions in patients with schizophrenia(2019-11-01) Sahbaz, Çiğdem Dilek; Kurtulmus, Ayse; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞEObjective: Dysregulation of biological rhythm is associated with reduced executive functioning and potentiating psychosis, which are essential for the Theory of Mind (ToM) among patients with schizophrenia. However, the association between cognitive dysfunction, emotional information and disruption of biological rhythm remains uncertain. Methods: Forty-one patients with schizophrenia and forty age, gender and smoking status-matched healthy controls were recruited into the study. The Wisconsin Card Sorting Test (WCST), The Stroop test, The Reading the Mind in the Eyes Test (RMET), The Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) were used. Results: BRIAN total, sleep, activity and social scores were higher in patients with schizophrenia than healthy controls. Higher BRIAN score was correlated with lower RMET score; with higher PANSS total, positive and negative scores, and not correlated with executive functions. In the regression analysis, it was observed that gender and increased BRIAN score was independently associated with lower scores for RMET in a patient with schizophrenia. Conclusion: These results suggest that the disruption of biological rhythm might be associated with ToM in patients with schizophrenia. Future research should examine the relationship between biological rhythm and ToM to determine if any causal associations can be identified.Publication Rabbit syndrome induced by aripiprazole(2016-04-24) KURTULMUŞ, AYŞE; ÖZTÜRK, AHMET; KURTULMUŞ, AYŞE; ÖZTÜRK, AHMETPublication Prescribing trends in treatment-resistant schizophrenia(2017-01-01T00:00:00Z) GÖRMEZ, AYNUR; KURTULMUŞ, AYŞE; Tuncer, Can; Çıtak, Serhat; KURTULMUŞ, AYŞEObjectives: Schizophrenia is a common mental health condition associated with significant morbidity and excess early mortality. Treatment-resistant schizophrenia (TRS) occurs in about one in three patients diagnosed with schizophrenia. The aim of this study was to identify attitudes of a nationally representative sample of psychiatrists towards pharmacotherapy of patients with TRS, the potential factors related to their choice of various regimens, and to investigate the clinical outcomes of different methods employed.Publication Antidepressants induced tardive dystonia a case report(2015-04-19) KURTULMUŞ, AYŞE; KIRPINAR, İSMET; DEVECİ, ERDEM; KOÇER, EMEL; GÖRMEZ, AYNUR; KURTULMUŞ, AYŞE; KIRPINAR, İSMET; DEVECİ, ERDEMPublication Evidence for an association of serum melatonin concentrations with recognition and circadian preferences in patients with schizophrenia.(2019-06-01) SAHBAZ, C; Özer, OF; KURTULMUS, AYŞE; KıRPıNAR, I; SAHIN, F; GULOKSUZ, S; ŞAHBAZ, ÇIĞDEM DILEK; ÖZER, ÖMER FARUK; KURTULMUŞ, AYŞE; KIRPINAR, İSMETPublication Bilişsel Bozulma Gösteren Yaşlı Hastalarda Ruhsal ve Davranışsal Belirtilerin Dağılımı(2014-11-16) KURTULMUŞ, AYŞE; KIRPINAR, İSMET; DEVECİ, ERDEM; KURTULMUŞ, AYŞE; KIRPINAR, İSMET; DEVECİ, ERDEMPublication A case of Niemann-Pick type C disease with juvenile onset neuropsychiatric symptoms(2016-10-01) Kirpinar, I.; GORMEZ, A.; KURTULMUS, AYŞE; KIRPINAR, İSMET; KURTULMUŞ, AYŞEPublication Lithoum use in the treatment of mental retardation comorbid with bipolar disorder: Two case reports(2017-01-01T00:00:00Z) GÖRMEZ, AYNUR; KURTULMUŞ, AYŞE; KURTULMUŞ, AYŞEMental Retardation (MR) is a spectrum of disorders characterized by deficits in intellectual and adaptive functioning which could result from a range of etiological factors. The prevalence of MR in the community is estimated to be about 1%. Presentation of psychiatric disorders in people with MR could be different from general population. Limited behavioral repertoire, cognitive capacity and communication difficulties can lead to atypical presentation of mental disorders. The prevalence figures for bipolar disorder in people with MR range from 0.9% to 4.8%. Considering the fact that vast majority of these patients are on antipsychotics, which can suppress some affective symptoms, it is possible that many cases with bipolar diagnosis are overlooked or are difficult to confirm. In these case reports, clinical presentation of two adult patients with bipolar disorder and their successful treatment with lithium is presented. We aim to raise awareness of bipolar disorder comorbidity, its atypical presentation and response to Lithium in this patient group.