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KURTULMUŞ, AYŞE

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Now showing 1 - 10 of 14
  • PublicationMetadata only
    Reduced regulatory T cells with increased proinflammatory response in patients with schizophrenia
    (2020-06-01T00:00:00Z) Sahbaz, Cigdem; Zibandey, Noushin; KURTULMUŞ, AYŞE; Duran, Yazgul; Gokalp, Muazzez; KIRPINAR, İSMET; ŞAHİN, FİKRETTİN; Guloksuz, Sinan; AKKOÇ, TUNÇ; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞE; KIRPINAR, İSMET
    Aim To investigate whether circulating T cells including regulatory T cells (Treg) and derived cytokines contribute to the immune imbalance observed in schizophrenia. Methods Forty patients with schizophrenia and 40 age, sex, body mass index, education, and smoking status-matched healthy controls (HC) are included in the study. We stained cells with anti-CD14, anti-CD3, anti-CD4, anti-CD8, anti-CD19, anti-CD20, and anti-CD16/56. Peripheral blood mononuclear cells (PBMCs) were isolated and stained with the human FoxP3 kit containing anti-CD4/anti-CD25 and intracellular anti-Foxp3. PBMCs were cultured for 72 h and stimulated with anti-CD3/anti-CD28. Cytokines (IL-2, IL-4, IL-6, IL-10, IFN-gamma, TNF-alpha, and IL-17A) were measured from the culture supernatant and plasma using the Th1/Th2/Th17 cytokine bead array kit. Results In comparison with HC, Treg percentages in schizophrenia were higher (1.17 +/- 0.63 vs 0.81 +/- 0.53, P = 0.005) in unstimulated but lower in the stimulated condition (0.73 +/- 0.69 vs 0.97 +/- 0.55, P = 0.011). Activated T cell percentages were higher in schizophrenia than HC in unstimulated (2.22 +/- 0.78 vs 1.64 +/- 0.89, P = 0.001) and stimulated (2.25 +/- 1.01 vs 1.72 +/- 1.00, P = 0.010) conditions. The culture supernatant levels of IL-6 (7505.17 +/- 5170.07 vs 1787.81 +/- 1363.32, P < 0.001), IL-17A (191.73 +/- 212.49 vs 46.43 +/- 23.99, P < 0.001), TNF-alpha (1557 +/- 1059.69 vs 426.57 +/- 174.62, P = 0.023), and IFN-gamma (3204.13 +/- 1397.06 vs 447.79 +/- 270.13, P < 0.001); and plasma levels of IL-6 (3.83 +/- 3.41vs 1.89 +/- 1.14, P = 0.003) and IL-17A (1.20 +/- 0.84 vs 0.83 +/- 0.53, P = 0.033) were higher in patients with schizophrenia than HC. Conclusion Our explorative study shows reduced level of Foxp3 expressing Treg in a stimulated condition with induced levels of proinflammatory cytokines in patients with schizophrenia.
  • PublicationMetadata only
    Eating disorders in patients with irritable bowel syndrome
    (2020-12-01T00:00:00Z) Kayar, Yusuf; Agin, Mehmet; Dertli, Ramazan; Kurtulmus, Ayse; Boyraz, Rabia Keyser; Onur, Nafiye Selcan; KIRPINAR, İSMET; KURTULMUŞ, AYŞE; ÖNÜR, NAFIYE SELCAN; KIRPINAR, İSMET
    Introduction: Eating disorders (ED) constitute an important group of conditions that commonly occur in adolescents. Gastrointestinal complaints are frequently reported in ED patients. Few studies assessed the association of irritable bowel syndrome (IBS) with ED. The aim of the current study is to determine the prevalence of ED in a group of IBS patients and compare it with a healthy control group and assess the relationship of IBS sub-types, it-s duration and severity with ED.
  • PublicationMetadata only
    Role of Lymphocyte Subsets and T-Cell Profiles in the Immune Dysfunction of Schizophrenia
    (2018-05-01) SAHBAZ, Cigdem; Zibandeyeh, Noushin; Kurtulmus, AYŞE; AVAROGLU, Gamze; Kirpinar, Ismet; Sahin, Fikrettin; AKKOÇ, TUNÇ; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞE; KIRPINAR, İSMET
  • PublicationMetadata only
    2 Kirpinar I, Gormez A, Kurtulmus A. A case of Niemann-Pick type C disease with juvenile onset neuropsychiatric symptoms.
    (2016-09-20) KIRPINAR, İSMET; Görmez, Aynur; Kurtulmuş, AYŞE; KIRPINAR, İSMET; KURTULMUŞ, AYŞE
  • PublicationMetadata only
    Antidepressants induced tardive dystonia a case report
    (2015-04-19) KURTULMUŞ, AYŞE; KIRPINAR, İSMET; DEVECİ, ERDEM; KOÇER, EMEL; GÖRMEZ, AYNUR; KURTULMUŞ, AYŞE; KIRPINAR, İSMET; DEVECİ, ERDEM
  • PublicationMetadata only
    Evidence for an association of serum melatonin concentrations with recognition and circadian preferences in patients with schizophrenia.
    (2019-06-01) SAHBAZ, C; Özer, OF; KURTULMUS, AYŞE; KıRPıNAR, I; SAHIN, F; GULOKSUZ, S; ŞAHBAZ, ÇIĞDEM DILEK; ÖZER, ÖMER FARUK; KURTULMUŞ, AYŞE; KIRPINAR, İSMET
  • PublicationMetadata only
    Rabbit syndrome induced by aripiprazole
    (2016-04-24) KURTULMUŞ, AYŞE; ÖZTÜRK, AHMET; KURTULMUŞ, AYŞE; ÖZTÜRK, AHMET
  • PublicationMetadata only
    Prescribing trends in treatment-resistant schizophrenia
    (2017-01-01T00:00:00Z) GÖRMEZ, AYNUR; KURTULMUŞ, AYŞE; Tuncer, Can; Çıtak, Serhat; KURTULMUŞ, AYŞE
    Objectives: Schizophrenia is a common mental health condition associated with significant morbidity and excess early mortality. Treatment-resistant schizophrenia (TRS) occurs in about one in three patients diagnosed with schizophrenia. The aim of this study was to identify attitudes of a nationally representative sample of psychiatrists towards pharmacotherapy of patients with TRS, the potential factors related to their choice of various regimens, and to investigate the clinical outcomes of different methods employed.
  • PublicationMetadata only
    Bilişsel Bozulma Gösteren Yaşlı Hastalarda Ruhsal ve Davranışsal Belirtilerin Dağılımı
    (2014-11-16) KURTULMUŞ, AYŞE; KIRPINAR, İSMET; DEVECİ, ERDEM; KURTULMUŞ, AYŞE; KIRPINAR, İSMET; DEVECİ, ERDEM
  • PublicationMetadata only
    A case of Niemann-Pick type C disease with juvenile onset neuropsychiatric symptoms
    (2016-10-01) Kirpinar, I.; GORMEZ, A.; KURTULMUS, AYŞE; KIRPINAR, İSMET; KURTULMUŞ, AYŞE