Person: BİRCAN, HACI AHMET
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Publication Open Access Research Burden of Interstitial Lung Diseases in Turkey - RBILD(2022-01-01T00:00:00Z) AYÇİÇEK, OLCAY; Cetinkaya, Erdogan; Ucsular, Fatma Demirci; BAYRAM, NAZAN; Senyigit, Abdurrahman; Aksel, Nimet; ATİLLA, NURHAN; Sarioglu, Nurhan; Niksarlioglu, Elif Yelda; Ilgazli, Ahmet; KILIÇ, TALAT; Günbatar, Hülya; Cilekar, Sule; EKİCİ, AYDANUR; Arinc, Sibel; Bircan, Haci Ahmet; Duman, Dildar; Dikis, Ozlem Sengoren; YAZICI, ONUR; Kansu, Abdulla; TUTAR, NURİ; Ozsari, Emine; BERK, SERDAR; Varol, Yelda; Erbaycu, Ahmet Emin; SERTOĞULLARINDAN, BÜNYAMİN; Cirak, Ali Kadri; Cortuk, Mustafa; Karadeniz, Gulistan; Simsek, Alper; SEZGİ, CENGİZHAN; EREL, FUAT; Ciftci, Tuba; Sünnetçioğlu, Aysel; EKİCİ, MEHMET SAVAŞ; Agca, Meltem; Ozturk, Onder; OGUN, HAMZA; Acar, Elif; Alizoroglu, Dursun; Gezer, Esma; ÖZLÜ, TEVFİK; BİRCAN, HACI AHMET; OGUN, HAMZAIntroduction: The aim of our study is to investigate the etiological distribution of ILD in Turkey by stratifying the epidemiological characteristics of ILD cases, and the direct cost of initial diagnosis of the diag-nosed patients. Material-Method: The study was conducted as a multicenter, prospective, cross-sectional, clinical observation study. Patients over the age of 18 and who accepted to participate to the study were included and evaluated as considered to be ILD. The findings of diagnosis, examination and treatment carried out by the cent-ers in accordance with routine diagnostic procedures were recorded observationally. Results: In total,1070 patients were included in this study. 567 (53%) of the patients were male and 503 (47%) were female. The most frequently diagnosed disease was IPF (30.5%). Dyspnea (75.9%) was the highest incidence among the presenting symptoms. Physical examination found bibasilar inspiratory crackles in 56.2 % and radiological findings included reticular opacities and interlobular septal thickenings in 55.9 % of the cases. It was observed that clinical and radiological findings were used most frequently (74.9%) as a diagnostic tool. While the most common treatment approaches were the use of systemic steroids and antifibrotic drugs with a rate of 30.7% and 85.6%, respectively. The total median cost from the patient-s admission to diagnosis was 540 Turkish Lira. Conclusion: We believe that our findings compared with data from other countries will be useful in showing the current situation of ILD in our country to discuss this problem and making plans for a solution.Publication Metadata only Serum biomarkers in patients with stable and exacerbated COPD-bronchiectasis overlap syndrome(2020-11-01T00:00:00Z) Sever, Zekiye Kula; BİRCAN, HACI AHMET; ŞİRİN, Fevziye Burcu; EVRİMLER, Şehnaz; ÇELİK, Seda; Merd, Neslihan; BİRCAN, HACI AHMETIntroduction Bronchiectasis (B), commonly seen in patients with chronic obstructive pulmonary disease (COPD), is associated with exacerbations and predicts mortality. Objectives To differentiate patient groups with COPD-(B+) or COPD-(B-) and their exacerbations by using inflammatory markers. Methods Consecutive COPD patients were divided into two groups according to findings on high resolution thorax CT (HRCT) images using Smith and modified Reiff scores. Patients were prospectively followed for possible future exacerbations. Serum fibrinogen, C-reactive protein (CRP), soluble urokinase-type plasminogen activator receptor (suPAR) and Plasminogen activator inhibitor-1 (PAI-1) levels were studied during exacerbation and stable periods. Results Eighty-seven patients were included and (85 M, 2 F), mean aged was 68.1 +/- 9 (46-87). HRCT confirmed bronchiectasis in 38 (43.7%) patients, most commonly in tubular form (89.4%) and in lower lobes. COPD-B(+) group had lower body mass index (P = 0.036), more advanced stage of disease (P = 0.004) and more frequent exacerbation (P = 0.01). The HRCT scores were correlated with exacerbation rate (r = 0.356,P < 0.05). Fibrinogen and CRP values were higher in exacerbation (P = 0.01,P = 0.013, respectively) especially in COPD-B(+) patients. suPAR and PAI-1 levels were also higher in COPD-B(+) patients although it was not statistically significant. Conclusion Bronchiectasis is common and causes frequent exacerbations in COPD. Identifying of COPD-B(+) phenotype by HRCT scoring systems has considerable importance for both therapeutic options and clinical outcome of the disease. In addition to fibrinogen and CRP, high serum levels of suPAR and PAI-1 suggest us their significant roles in increased systemic inflammation associated with coexisting of COPD and bronchiectasis.Publication Metadata only The usefulness and prognostic value of Memorial Symptom Assessment-Short Form and Condensed Memorial Symptom Assessment Scale in assessment of lung cancer patients(2020-04-01T00:00:00Z) BİRCAN, HACI AHMET; Yalcin, Gonul Seven; FİDANCI, Sümeyye; KARAİBRAHİMOĞLU, Adnan; Tuglu, Hatice Celik; BİRCAN, HACI AHMETPurpose Lung cancer is associated with high level of symptoms and patient-reported symptoms have been rarely used as a prognostic score to predict patients survival. Methods Frequency and burden of symptoms in lung cancer patients were evaluated before the diagnosis with the Memorial Symptom Assessment-Short Form (MSAS-SF) and Condensed Memorial Symptom Assessment Scale (CMSAS) questionnaires. Performance status, stage of disease, serum albumin, and C-reactive protein (CRP) levels were recorded. Patients were staged according to 8th TNM classification. A survival analysis was applied. Results The mean age of 116 patients (adenocarcinoma 51, squamous cell 43, non-small cell 5, small cell 17) was 65.2 +/- 10.1 (28-87) years. The most common seen physical and psychological symptoms were cough (86.3%), lack of energy (74.3%), dyspnea (70.1%), and feeling sad (61.5%), feeling nervous (61.5%), and worrying (53.8%). Total and subscores of MSAS and CMSAS are significantly higher in M1 disease than M0 disease. All MSAS-SF and CMSAS scores, but not MSAS-PSYCH and CMSAS-PSYCH, positively correlated with age, high serum CRP, white blood cells/neutrophils counts, and TNM stage, and negatively correlated with albumin levels, performance status, and overall survival (OS). Median survival was 77, 195, 370, and 579 days for the four prognostic interquartile groups according to CMSAS-SUM score (p < 0.0001). Conclusion MSAS-SF and CMSAS questionnaires can be useful tool for discriminating metastatic from non-metastatic disease in treatment-naive patients with lung cancer. Since both questionnaires well correlated with OS and important prognostic factors, they can use to plan palliative care and to help for predicting survival of lung cancer patients.Publication Metadata only A Rare Anomaly of the Aortic Arch: Kommerell Diverticulum Accompanying the Right-sided Aortic Arch and Aberrant Left Subclavian Artery(2021-04-01T00:00:00Z) Tuğba Canlı, Esma; Yıldız, Veysel; Bircan, Hacı Ahmet; BİRCAN, HACI AHMETPublication Metadata only Aspergilloma and Idiopathic Pulmonary Fibrosis: A Rare Coexistence.(2021-06-01T00:00:00Z) Bircan, Hacı Ahmet; Akcan, Ahmet; BİRCAN, HACI AHMETPulmonary aspergilloma (mycetoma) usually is a saprophytic fungal infection due to aspergillus species which is colonized and grows into pre-existing cystic/ cavitary lesions resulting from pulmonary tuberculosis or fibrotic sarcoidosis, or other fibro-cavitary diseases including interstitial lung diseases. Idiopathic pulmonary fibrosis (IPF) is a rare, chronic, progressive fibrotic lung disease, characterized by the histological pattern of usual interstitial pneumonia. Heavy smoker, diabetic, a 69-year-old male patient was admitted to our clinic with complaints of dry cough, fever, dyspnea on exertion and weight loss. The diagnosis was made as coexisting of pulmonary aspergilloma and IPF according to findings on HRCT. Hereby, we wanted to present this rare case regarding of coexisting of the development of Aspergillus infection and idiopathic pulmonary fibrosis in the light of the literature.Publication Metadata only Do complete blood count parameters predict diagnosis and disease severity in obstructive sleep apnea syndrome?(2021-01-01T00:00:00Z) ÖZYURT, SONGÜL; Zorlu, D.; BİRCAN, HACI AHMET; Erturk, A.; BİRCAN, HACI AHMETOBJECTIVE: Inflammation and platelet activation play a role in the pathogenesis of obstructive sleep apnea syndrome (OSAS). In this study, it was aimed to investigate the effectiveness of the systemic inflammation markers, the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and WMR (white blood cell count (WBC) to mean platelet volume (MPV) ratio), in determining the severity of OSAS.