Person: BİRCAN, HACI AHMET
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Publication Metadata only Respiratory Symptoms, Pulmonary Function, and Reproductive History: Isparta Menopause and Health Study(2010-06-01T00:00:00Z) Songur, Necla; AYDIN, Zeynep Dilek; ÖZTÜRK, Önder; Sahin, Unal; Khayri, Ulugbik; Bircan, Ahmet; AKKAYA, Ahmet; BİRCAN, HACI AHMETObjective: We aimed to investigate the influence of reproductive factors on chronic respiratory symptoms and pulmonary function in a cross-sectional study of premenopausal and postmenopausal women 44-61 years of age.Publication Metadata only Ratio And Regional Distribution Of Genetic Mutation In Lung Cancer In Turkey (REDIGMA)(2018-09-01T00:00:00Z) Ozcelik, Neslihan; ÖZLÜ, TEVFİK; Aksel, Nimet; BÜLBÜL, YILMAZ; Erdogan, Yurdanur; Guldaval, Filiz; Gul, Sule Karabulut; Bircan, Ahmet; Can, Atilla; Oz, Necdet; Senturk, Aysegul; Arinc, Sibel; Kilic, Talat; Kurt, Bahar; GÜNAY, ERSİN; Caglayan, Benan; Aydin, Derya Celebi; BAŞYİĞİT, İLKNUR; Savas, Ismail; Tatar, Dursun; Aslan, Sulhattin; Komurcuoglu, Berna; BAYRAM, MEHMET; GÜLMEZ, İNCİ; DOĞAN, ÖMER TAMER; Niksarlioglu, Elif Yelda; Kaba, Erkan; Ozgur, Esra Aydin; BİRCAN, HACI AHMET; BAYRAM, MEHMETPublication Metadata only The diagnostic significance of signal peptide-complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein-1 levels in pulmonary embolism(2016-10-01T00:00:00Z) Dirican, Nigar; Duman, Ali; Saglam, Gulcan; Arslan, Akif; ÖZTÜRK, Önder; Atalay, Sule; Bircan, Ahmet; AKKAYA, Ahmet; ÇAKIR, Münire; BİRCAN, HACI AHMETBACKGROUND: Pulmonary embolism (PE) is a common and potentially life-threatening disorder. Patients with PE often have nonspecific symptoms, and the diagnosis is often delayed.Publication Metadata only Broncholithiasis with Recurrent Lithoptysis: A Case Report(2014-01-01T00:00:00Z) Bircan, Ahmet; Onur, Duygu; Yilmaz, Aydin; BİRCAN, HACI AHMETObjective: To report a case of broncholithiasis with different types of calculi in the tracheobronchial tree. Clinical Presentation and Intervention: A 50-year-old male who suffered from hemoptysis presented with recurrent broncholith expectoration due to past tuberculous middle lobe syndrome. Bronchoscopic examination revealed loose and embedded broncholiths located at two different bronchi. A surgical resection was suggested, but he refused. Conclusion: The diagnosis of broncholithiasis should be kept in mind in patients who had hemoptysis and calcified mediastinal lymph nodes on thorax computerized tomography, and diagnostic bronchoscopy should be done to prove the relationship of the tracheobronchial tree with a broncholith. (C) 2013 S. Karger AG, BaselPublication Metadata only Pulmonary carcinosarcoma: a case report.(2011-01-01T00:00:00Z) Bektaş, Sevda Sert; Bircan, Sema; Bircan, Ahmet; Sirmali, Mehmet; Günes, Sedat; Bozkurt, Kemal K; Devrim, Tuba; BİRCAN, HACI AHMETPublication Metadata only Patient and physician delay in the diagnosis and treatment of non-small cell lung cancer in Turkey(2015-04-01T00:00:00Z) YURDAKUL, AHMET SELİM; Kocaturk, Celalettin; Bayiz, Hulya; Gursoy, Soner; Bircan, Ahmet; Ozcan, Aysenaz; Akkoclu, Atilla; Uluorman, Funda; Celik, Pinar; KÖKSAL, DENİZ; Ulubas, Bahar; Sercan, Eylem; Ozbudak, Omer; Goksel, Tuncay; Onalan, Tugba; Yamansavci, Esra; Turk, Figen; Yuncu, Gokhan; Copuraslan, Cigdem; Mardal, Tugba; Tuncay, Esin; Karamustafaoglu, Altemur; Yildiz, Pinar; Secik, Funda; Kaplan, Muhammet; Caglar, Emel; Ortakoylu, Mediha; Onal, Mine; Turna, Akif; Hekimoglu, Evlin; Dalar, Levent; Altin, Sedat; Gulhan, Meral; Akpinar, Eylem; Savas, Ismail; Firat, Nalan; Camsari, Gungor; Ozkan, Gulcihan; Cetinkaya, Erdogan; Kamiloglu, Emine; Celik, Bulent; Havlucu, Yavuz; BİRCAN, HACI AHMETAim: The early diagnosis and treatment of lung cancer are important for the prognosis of patients with lung cancer. This study was undertaken to investigate patient and doctor delays in the diagnosis and treatment of NSCLC and the factors affecting these delays.Publication Metadata only Patient and doctor delays in the diagnosis and treatment of non-small cell lung cancer in Turkey(2013-09-01T00:00:00Z) Yurdakul, Ahmet; Kocaturk, Celalettin; Bayiz, Hulya; Gursoy, Soner; Bircan, Ahmet; Ozcan, Aysenaz; Akkoclu, Atilla; Uluorman, Funda; Celik, Pinar; KÖKSAL, DENİZ; Ulubas, Bahar; Sercan, Eylem; Ozbudak, Omer; Goksel, Tuncay; Onalan, Tugba; Yamansavci, Esra; Turk, Figen; Yuncu, Gokhan; Copuraslan, Cigdem; Mardal, Tugba; Tuncay, Esin; Karamustafaoglu, Altemur; Yildiz, Pinar; Secik, Funda; Kaplan, Muhammet; Caglar, Emel; Ortakoylu, Mediha; Onal, Mine; Turna, Akif; Hekimoglu, Evlin; Dalar, Levent; Altin, Sedat; Gulhan, Meral; Akpinar, Eylem; Savas, Ismail; Firat, Nalan; Camsari, Gungor; Ozkan, Gulcihan; Cetinkaya, Erdogan; Kamiloglu, Emine; Celik, Bulent; Havlucu, Yavuz; BİRCAN, HACI AHMETPublication Metadata only EGFR and KRAS mutations in Turkish non-small cell lung cancer patients: a pilot study(2014-08-01T00:00:00Z) BİRCAN, Sema; Baloglu, Huseyin; Kucukodaci, Zafer; Bircan, Ahmet; BİRCAN, HACI AHMETEGFR and KRAS mutation profile in non-small cell lung cancers (NSCLCs) shows wide variations due to geographic and ethnic background. We aimed to determine the frequency and types of EGFR and KRAS mutations in a sample group of Turkish NSCLC cases. The study included 14 adenocarcinomas (ACs), 11 squamous cell carcinoma (SCC) patients selected from archival material including small biopsy or surgical specimens. Their formalin fixed paraffin-embedded tumor tissues were used for genomic DNA extraction for EGFR exon 19 and 21, and KRAS exon 2 mutations. Eleven NSCLCs (44 %) had EGFR mutations. Exon 19 and 21 mutations were found in 8 (32 %) and 5 (20 %) cases. Two cases showed double EGFR mutations. In ACs, 5 (35.7 %) patients had EGFR gene mutation, 3 in exon 19 and 3 in exon 21. In SCCs, 6 (54.5 %) cases had EGFR mutation, 5 in exon 19 and 2 in exon 21. All exon 19 mutations were deletion-type mutations. For exon 21, 3 cases had L858R point mutation (CTG>CGG) and two cases showed deletion-type mutations. Six (24 %) NSCLCs showed KRAS mutations (three ACC, three SCC), 5 codon 12 mutations (G>T, T>C, G>A) and one codon 13 mutation (G>T). Three NSCLC cases showed both EGFR and KRAS mutations together. The profile of KRAS mutation in our AC cases was quite similar to those seen in the Western countries; however, frequency and clustering of EGFR mutations were similar to those seen in the Eastern countries.Publication Metadata only A Simple Clinical Model Composed of ECG, Shock Index, and Arterial Blood Gas Analysis for Predicting Severe Pulmonary Embolism(2011-04-01T00:00:00Z) Bircan, Ahmet; Karadeniz, Nuriye; Ozden, Ahmet; ÇAKIR, Münire; VAROL, Ercan; Oyar, Orhan; Ozaydin, Mehmet; BİRCAN, HACI AHMETBackground: Objective diagnosis of severe pulmonary embolism (PE) is obligatory because of its considerable mortality. Aim: To assess the abilities of electrocardiography (ECG) score (sECG) and the newly generated scoring system composed of the scores obtained from arterial blood gas (ABG) analysis and shock index (SI) in addition to sECG in predicting severe PE. Material and Methods: The degree of pulmonary vascular obstruction (sPVO) and the right ventricular dysfunction (RVD) were determined with spiral computed tomography (CT) in 53 consequent patients with PE. Twelve-lead ECG taken within a day of PE event and ABG values were evaluated according to ECG scoring system and original Geneva system, respectively. Results: The mean age of patients was 62.6 +/- 13.4 years. Right ventricular dysfunction, sPVO >= 50%, hypoxemia, and SI were present in 34 (64.2%), 27 (50.9%), 50 (94.3%), and 22 (41.5%) patients, respectively. The mean sECG, 5.9 +/- 5.1, was correlated with sPVO, maximum diameter of right ventricle (RV), and right ventricle to left ventricle (RV/LV) ratio (r = .385, r = .415, and r = .329, respectively). The mean newly generated score was 10.9 +/- 5.5 and correlated with sPVO, maximum diameter of RV, and RV/LV ratio (r = .394, r = .483, and r = .393, respectively). Receiver operator characteristic (ROC) curve analyses revealed that sECG >= 3.5, s (ECG + SI) >= 4.5, and s (ECG + SI + ABG) >= 9.5 predict the severe PE patients with 70.6%, 61.8%, 58.8% sensitivities and 52.6%, 63.2%, 73.7% specificities, respectively. Conclusion: Adding the scores obtained from SI and ABG to the sECG enhances the specificity of sECG in predicting RVD (+) or severe PE patients, although a lesser degree decreasing in sensitivity may occur.Publication Metadata only Alopecia Areata Associated with Thymoma Presenting as a Diffuse Pleural Dissemination Mimicking Mesothelioma: Rare Concomitant Presentation(2010-02-01T00:00:00Z) Songur, Necla; Basak, Pinar Yueksel; ÖZTÜRK, Önder; SAK, SERPİL; Cerci, Sevim Suereyya; Sirmali, Mehmet; Bircan, Ahmet; BİRCAN, HACI AHMETA 42-year-old man presented with dyspnea, left-sided chest pain and sudden onset of hair loss. Multiple pleural masses were found on computed tomographic scans which were highly suggestiveof malignant pleural mesothelioma or pleural metastases. After open pleural biopsy, pathological examination showed the lesion to be a metastatic pleural thymoma or primary pleural thymoma with an exceptional localization. Clinical signs and symptoms of myasthenia gravis (MG) were absent and anti-acetylcholine -receptor antibodies were in normal range. Electromyogram was normal. PET-CT showed anterior-superior hypermetabolic partially calcified mass (malignant thymoma, SUV: 4-4. 2) located to the thymus. The patient was diagnosed as alopecia areata (AA) in the view of dermatological findings. Association of AA and thymoma was previously reported in the presence of MG as individual cases. Nevertheless, this case represents an unusual form of metastatic thymoma with diffuse pleural dissemination mimicking malignant mesothelioma associated with AA, but not accompanied by MG. It should be emphasized that dermatologists must be aware of the clinical findings of a pulmonary disease such as thymoma in patients with AA.