Person: BİRCAN, HACI AHMET
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Publication Metadata only Respiratory Symptoms, Pulmonary Function, and Reproductive History: Isparta Menopause and Health Study(2010-06-01T00:00:00Z) Songur, Necla; AYDIN, Zeynep Dilek; ÖZTÜRK, Önder; Sahin, Unal; Khayri, Ulugbik; Bircan, Ahmet; AKKAYA, Ahmet; BİRCAN, HACI AHMETObjective: We aimed to investigate the influence of reproductive factors on chronic respiratory symptoms and pulmonary function in a cross-sectional study of premenopausal and postmenopausal women 44-61 years of age.Publication Metadata only The diagnostic significance of signal peptide-complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein-1 levels in pulmonary embolism(2016-10-01T00:00:00Z) Dirican, Nigar; Duman, Ali; Saglam, Gulcan; Arslan, Akif; ÖZTÜRK, Önder; Atalay, Sule; Bircan, Ahmet; AKKAYA, Ahmet; ÇAKIR, Münire; BİRCAN, HACI AHMETBACKGROUND: Pulmonary embolism (PE) is a common and potentially life-threatening disorder. Patients with PE often have nonspecific symptoms, and the diagnosis is often delayed.Publication Metadata only Thiol/disulfide homeostasis: A prognostic biomarker for patients with advanced non-small cell lung cancer?(2016-01-01T00:00:00Z) Dirican, Nigar; Dirican, Ahmet; Sen, Orhan; Aynali, Ayse; Atalay, Sule; BİRCAN, HACI AHMET; ÖZTÜRK, Önder; Erdogan, Serpil; ÇAKIR, Münire; AKKAYA, Ahmet; BİRCAN, HACI AHMETBackground: The aim of this study was to investigate oxidative stress and thiol/disulfide status with a novel automated homeostasis assay in advanced non-small cell lung cancer ( NSCLC).Publication Metadata only Evaluation of Heterozygous Deletion of TP53 Gene in Pleural Fluid Samples: A Case Series of 11 Patients(2016-04-01T00:00:00Z) Dirican, Nigar; Bagci, Ozkan; Uz, Efkan; ÖZTÜRK, Önder; BİRCAN, HACI AHMET; Dirican, Ahmet; BİRCAN, HACI AHMETWe described heterozygous deletion of tumor protein 53 (TP53) gene in 11 patients including 2 patients with non- malignant diseases (pneumonia) and 9 patients with malignant diseases [including small cell lung cancer (n = 3), non-small cell lung carcinoma (n = 4), non-Hodgkin-s lymphoma (n= 1), and gastric carcinoma (n= 1)]. Chromosomal aberrant status was analyzed by fluorescence in situ hybridization with centromere specific and 17p13.1 locus specific probes. In 3 of 9 cancer patients we did not find malignant pleural effusion with histological examination and/or closed pleural biopsy. Heterozygous deletion of TP53 gene was found to be significantly higher in patients with malignant disease when compared to the patients with benign pleural fluid. As a result, we suggest that heterozygous deletion of TP53 may have indicator value for malignancy; however further studies are warranted to confirm this suggestion in large patient cohorts.Publication Metadata only Soluble Urokinase Plasminogen Activator Receptor (suPAR) in the Diagnosis of Pulmonary Embolism(2017-01-01T00:00:00Z) Dirican, Nigar; Aynali, Ayse; ÇAKIR, Münire; Atalay, Sule; BİRCAN, HACI AHMET; ÖZTÜRK, Önder; AKKAYA, Ahmet; BİRCAN, HACI AHMETAim: The goal of our study was to compare the suPAR levels between pulmonary embolism (PE) patients and healthy subjects and also to investigate the value of suPAR in the diagnosis of PE. Material and Method: Thirty patients diagnosed with acute PE using spiral computerized tomographic pulmonary angiography were included in the study. suPAR and D-dimer levels were measured at the time of diagnosis. Twenty-nine age-and sex-matched healthy subjects were chosen for the study. The suPARnostic ELISA Standard Kit (ViroGates A/S, Birkerod, Denmark, Code No. A001) was used for the quantitative determination of suPAR levels in plasma samples. Results: Median (95% CI) suPAR level measured in the PE group was 6.4 (6.4-10.5) ng/mL, compared to 3.3 (2.9-4.2) ng/mL in the control group (P< 0.001). suPAR levels were significantly higher in the patients with PE than in controls (P< 0.001). Receiver operator characteristic (ROC) curve analysis was found as 0.871 [confidence interval (CI) 0.776-0.965] area under the curve, 83% specificity, and 82% sensitivity at the cut-off of suPAR. Patients with higher suPAR (4.3 ng/ml) had significantly longer hospital stays than patients with lower suPAR (p= 0.049). There was a statistically significant positive correlation between D-dimer and suPAR (r= 0.530, P= 0.004). Discussion: This study suggests that suPAR may be a biomarker with good sensitivity and specificity for diagnosis of PE. However, large prospective studies are required to demonstrate the diagnostic and prognostic significance of suPAR in PE.Publication Metadata only Effects on prognosis of hematologic parameters in patients with small cell lung cancer(2016-01-01T00:00:00Z) Dirican, Nigar; Anar, Ceyda; Atalay, Sule; ÖZTÜRK, Önder; BİRCAN, HACI AHMET; ÇAKIR, Münire; AKKAYA, Ahmet; BİRCAN, HACI AHMETPurpose: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are prognostic factors for various types of cancer. In this study, we assessed the association of NLR and PLR with the prognosis of small-cell lung cancer (SCLC) in patients who received the standard treatment.Publication Metadata only Elevated serum matrix metalloproteinase-2 and-9 and their correlations with severity of disease in patients with community-acquired pneumonia(2015-01-01T00:00:00Z) BİRCAN, HACI AHMET; ÇAKIR, Münire; Kapulu, Ilkay Yilmazer; Sutcu, Recep; Kaya, Seluk; ÖZTÜRK, Önder; BİRCAN, HACI AHMETBackground/aim: To determine the role of matrix metalloproteinases (MMPs) and their relationship with the clinical course of community-acquired pneumonia (CAP).Publication Metadata only Alopecia Areata Associated with Thymoma Presenting as a Diffuse Pleural Dissemination Mimicking Mesothelioma: Rare Concomitant Presentation(2010-02-01T00:00:00Z) Songur, Necla; Basak, Pinar Yueksel; ÖZTÜRK, Önder; SAK, SERPİL; Cerci, Sevim Suereyya; Sirmali, Mehmet; Bircan, Ahmet; BİRCAN, HACI AHMETA 42-year-old man presented with dyspnea, left-sided chest pain and sudden onset of hair loss. Multiple pleural masses were found on computed tomographic scans which were highly suggestiveof malignant pleural mesothelioma or pleural metastases. After open pleural biopsy, pathological examination showed the lesion to be a metastatic pleural thymoma or primary pleural thymoma with an exceptional localization. Clinical signs and symptoms of myasthenia gravis (MG) were absent and anti-acetylcholine -receptor antibodies were in normal range. Electromyogram was normal. PET-CT showed anterior-superior hypermetabolic partially calcified mass (malignant thymoma, SUV: 4-4. 2) located to the thymus. The patient was diagnosed as alopecia areata (AA) in the view of dermatological findings. Association of AA and thymoma was previously reported in the presence of MG as individual cases. Nevertheless, this case represents an unusual form of metastatic thymoma with diffuse pleural dissemination mimicking malignant mesothelioma associated with AA, but not accompanied by MG. It should be emphasized that dermatologists must be aware of the clinical findings of a pulmonary disease such as thymoma in patients with AA.Publication Metadata only The attitude toward tobacco dependence and barriers to discussing smoking cessation: a survey among Turkish general practitioners(2010-06-01T00:00:00Z) Gokirmak, Munire; ÖZTÜRK, Önder; Bircan, Ahmet; AKKAYA, Ahmet; BİRCAN, HACI AHMETTo evaluate the general attitude of a sample of Turkish general practitioners (GPs) toward tobacco dependence and to assess their knowledge and behavior regarding smoking cessation (SC).Publication Metadata only Maspin, VEGF and p53 Expression in Small Biopsies of Primary Advanced Lung Cancer and Relationship with Clinicopathologic Parameters(2010-12-01T00:00:00Z) Bircan, Ahmet; BİRCAN, Sema; Kapucuoglu, Nilgun; Songur, Necla; ÖZTÜRK, Önder; AKKAYA, Ahmet; BİRCAN, HACI AHMETMaspin, one of the serine protease inhibitors, has been shown to inhibit tumor progression and metastasis. We aimed to investigate maspin, p53 and VEGF expression in patients with squamous cell carcinoma (SCC), adenocarcinoma (AC) and small cell lung carcinoma (SCLC). The study included 28 SCC, 18 AC, 17 SCLC biopsy samples. We used the streptavidin biotin immunoperoxidase method to test for maspin, p53 and VEGF antibodies. Medical records of these patients were reviewed from archival files. Cytoplasmic maspin expression was detected in 89.3%, 77.8%, 52.9% of SCC, AC and SCLC, respectively. The rate was significantly higher in non-small cell lung cancer (NSCLC) and SCC than SCLC (p=0.013,p= 0.021, respectively). The mean percentages of maspin expression were significantly higher in NSCLC, SCC and AC than in SCLC (p=0.000 I, p=0.000 I, p=0.038, respectively). In ACs, maspin and p53 expressions were correlated, although this was not statistically significant (p=0.053, r= 0.464), and maspin positive cases had a significantly higher T status compared to negative cases (p=0.036). In SCC, the stage of disease was positively correlated with p53 (p= 0.007, r=0.536) and negatively correlated with VEGF expression (p=0.013, r=-0.498). Multivariate analysis demonstrated that stage of disease was a significant independent prognostic parameter in NSCLC (95% confidence interval: 1.067-3.969; p=0.031). Although maspin expression is higher in SCC and AC, and is related with higher T status in AC, our data did not indicate its prognostic significance. Larger scale studies are needed to reveal the exact role of maspin in lung cancer pathogenesis.