Person: ŞAHİN, NURHAN
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Publication Open Access Report of a Case of Signet Ring Carcinoma Presenting as Gastric Mucosal Thickening: A Diagnostic Dilemma(2021-01-01T00:00:00Z) Karatoprak, Cumali; Akçakaya, Adem; Şentürk, Hakan; Çoban, Ganime; Şahin, Nurhan; Türk, Hacı Mehmet; KARATOPRAK, CUMALİ; AKÇAKAYA, ADEM; ŞENTÜRK, HAKAN; ÇOBAN, GANİME; ŞAHİN, NURHAN; TÜRK, HACI MEHMETThe number of cancer cases has been increasing worldwide. Early diagnosis and tumor resection remain as the most effective treatments for gastric cancer. However, early diagnosis is not always possible as it is frequently not possible to make treatment decisions without pathologic diagnosis in patients with clinically suspected cancer. This causes delays in diagnosing cancer. We presented a 58 years old woman with gastric signet ring cell carcinoma that could not be diagnosed despite using four different methods of stomach biopsies. We aimed to emphasize that despite the use of advanced methods, if clinical cancer in non-diagnosed cases is suspected, we should be more aggressive for early diagnosis.Publication Open Access Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer(2018-09-01T00:00:00Z) YILMAZ, ERCAN; GÜL, MEHMET; MELEKOĞLU, RAUF; Coskun, Ebru Inci; Sahin, NURHAN; GÜL, SEMİR; BAŞTEMUR, AYŞE GÜLÇİN; Ciplak, Baris; ŞAHİN, NURHANObjectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer.Publication Metadata only Clinical and Pathological Findings on Intoxication by Yellow Phosphorus After Ingesting Firework Cracker: A Rare Case of Autopsy(2016-01-01T00:00:00Z) Samdanci, Emine Turkmen; Cakir, Ebru; Sahin, NURHAN; Elmali, Candan; Sayin, Sadegul; ŞAHİN, NURHANYellow phosphorus is a toxic substance used in the production of firework cracker, fireworks, ammunition and agricultural dung. When ingested, it shows its effects mainly in the liver, the kidneys, and the brain. A four-year-old girl had died as a result of acute hepatic failure caused by ingesting a firework cracker. The case showed high levels of hepatic enzymes, along with non-specific signs such as nausea, vomiting and diarrhea. Autopsy revealed diffuse microvesicular steatosis in the liver and disseminated degeneration in the proximal tubules of the kidneys. In cases with concomitant hepatorenal failure and cardiovascular collapse, death is inevitable. However, when only hepatic failure develops, hepatic transplantation may be lifesaving. Although intoxication from ingesting yellow phosphorus has a very high rate of mortality, forensic cases are extremely rare in the literature.Publication Metadata only Vulvar vestibular papillomatosis(2012-12-01T00:00:00Z) Bilgic, Ozlem; Karincaoglu, Yelda; Sahin, NURHAN; ŞAHİN, NURHANVestibular papillomatosis (VP) is a benign, asymptomatic anatomical condition present in approximately 1% of women. It is characterized by linear, pink, smooth or filiform papules symmetrically distributed on the vulva. The clinical resemblance of VP to genital warts may lead to unnecessary laboratory tests and treatments. This report presents four cases of VP in order to call attention to this entity (Turkderm 2012; 46: 220-2)Publication Metadata only Histopathological subtyping of actinic keratosis and it-s coexistence with nonmelanotic skin cancers in Gaziantep and Malatya regions(2016-01-01T00:00:00Z) Sahin, NURHAN; Bozdag, Zehra; Erkilic, Suna; Aydin, Nasuhi Engin; ŞENER, SERPİL; ŞAHİN, NURHANBackground and Design: Actinic (solar) keratosis (AK) is a precancerous, epidermal lesion, which develops in sensitive skin exposed to sun for a long period. AKs are divided into different histopathological subtypes. There is a link between the clinical progression of the histopathological subtypes, the degree of cellular atypia, and the precancerous nature of the lesion. Different series have reported that the rate of transformation of AK to squamous cell carcinoma (SCC) ranges between 12% and 20%.Publication Metadata only Protective effects of hesperidin in experimental testicular ischemia/reperfusion injury in rats(2016-10-01T00:00:00Z) Celik, Emrah; OĞUZTÜRK, HAKAN; Sahin, NURHAN; TURTAY, MUHAMMET GÖKHAN; OĞUZ, FATİH; ÇİFTÇİ, OSMAN; ŞAHİN, NURHANIntroduction: In this study, we aimed to determine the protective effects of hesperidin, a citrus flavonoid, in a model of testicular ischemia/reperfusion injury in rats.Publication Open Access Effect of microfracture and autologous-conditioned plasma application in the focal full-thickness chondral defect of the knee: an experimental study on rabbits(2015-07-16) KARAKAPLAN, MUSTAFA; Sahin, Nurhan; MIREL, Efe; Ergen, Emre; ELMALI, Candan; ELMALI, NURZAT; ŞAHİN, NURHANPurpose: The aim of the present study was to evaluate the effect of microfracture and intraarticular autologous conditioned plasma (ACP) injection on cartilage regeneration in a focal full-thickness chondral defect model created in the knee joint. Methods: Full-thickness chondral defects of 3 × 6 mm(2) were surgically created in right medial femoral condyles (MFC) of New Zealand rabbits, and the rabbits were then divided into three groups according to treatment: Group 1 received only microfracture (mfx), Group 2 received mfx plus intraarticular ACP, and Group 3 received mfx; the defect was covered by the periosteum, and then, ACP was applied subperiosteally and intraarticularly. Twelve weeks after injection, the animals were sacrificed and the femoral condyles were evaluated macroscopically and histologically by hematoxylin-eosin staining. Then, histological sections were scored using the International Cartilage Repair Society (ICRS) visual histological scale. Results: Findings showed that in both mfx/ACP-treated groups, the defects were filled regularly and smoothly, the defects had a greater fill and good integration into the surrounding host tissue, and the repair matrix had more hyaline-like character. On the other hand, defects were filled with an irregular, fibrous cartilage in the mfx-treated group. Histological scores in Group 2 and Group 3 were better compared to Group 1. Conclusion: In the present study, we were able to demonstrate a beneficial effect of intraarticular administration of ACP as a coadjuvant of microfractures in order to regenerate hyaline-like cartilage in full-thickness chondral lesions in a rabbit model.Publication Open Access What does the Data of 354,725 Patients from Turkey Tell Us About Cervical Smear Epithelial Cell Abnormalities? - The Epithelial Cell Abnormality Rate is Increasing - Quality Control Studies and Corrective Activity are Musts(2017-05-01) Turkmen, Ilknur Cetinaslan; USUBÜTÜN, ALP; Cakir, Asli; Aydin, Ozlem; Bolat, Filiz Aka; Akbulut, Metin; ALTINAY, Serdar; Arici, Sema; ASLAN, Figen; Astarci, Muzeyyen; Bagir, Emine Kilic; Bas, Yilmaz; Bassullu, Nuray; CELIK, Betul; CETINER, Handan; Cobanoglu, Bengu; Aydin, Abdullah; Demir, Hale; Dogan, Hayriye Tatli; EKEN, Kamile Gulcin; ERHAN, Selma Sengiz; Erdogan, Gulgun; Sahin, Nurhan; ERDOGAN, Kivilcim Eren; Eren, Funda; Ersoz, Safak; Firat, Pinar; Gurses, Iclal; Haberal, Nihan; KAHRAMAN, Dudu Solakoglu; KAMALI, Gulcin Harman; KARABULUT, Yasemin Yuyucu; Kefeli, Mehmet; Koyuncuoglu, Meral; Koseoglu, R. Dogan; Muezzinoglu, Bahar; ONAL, Binnur; Onder, Sevgen; OZCAN, Zuhal; KIMILOGLU, Elife; Ozer, Hatice; SONMEZ, F. Cavide; Sahin, Sevinc; Yalta, Tulin; ARICI, DILEK SEMA; ŞAHİN, NURHANObjective: There is no other screening program close to the success rate of PAP test. Cervical cytology constitutes a large workload so that quality control in cervical cytology is important for the quality assurance of pathology laboratories.Publication Metadata only The Effect of Bemiparine Na and Hyaluronic Acid on Postoperative Adhesions in Rat Uterine Horn Model(2022-03-14) Baydemir S.; Gökmen Karasu A. F.; Turna S.; Şahin N.; GÖKMEN KARASU, AYŞE FİLİZ; TURNA, SEVAL; ŞAHİN, NURHANPublication Metadata only Unexpected Discoveries: Uncovering Incidental Tumors in Simple Nephrectomy Specimens(2023-11-01) Çoban G.; Coşanay Tekden B.; Şahin N.; Toluk Ö.; Toprak H.; Yıldız P.; İlktaç A.; ÇOBAN, GANİME; COŞANAY TEKDEN, BÜŞRA; ŞAHİN, NURHAN; TOLUK, ÖZLEM; TOPRAK, HÜSEYİN; İLKTAÇ, ABDULLAH