Person: ŞAHİN, NURHAN
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Publication Open Access Report of a Case of Signet Ring Carcinoma Presenting as Gastric Mucosal Thickening: A Diagnostic Dilemma(2021-01-01T00:00:00Z) Karatoprak, Cumali; Akçakaya, Adem; Şentürk, Hakan; Çoban, Ganime; Şahin, Nurhan; Türk, Hacı Mehmet; KARATOPRAK, CUMALİ; AKÇAKAYA, ADEM; ŞENTÜRK, HAKAN; ÇOBAN, GANİME; ŞAHİN, NURHAN; TÜRK, HACI MEHMETThe number of cancer cases has been increasing worldwide. Early diagnosis and tumor resection remain as the most effective treatments for gastric cancer. However, early diagnosis is not always possible as it is frequently not possible to make treatment decisions without pathologic diagnosis in patients with clinically suspected cancer. This causes delays in diagnosing cancer. We presented a 58 years old woman with gastric signet ring cell carcinoma that could not be diagnosed despite using four different methods of stomach biopsies. We aimed to emphasize that despite the use of advanced methods, if clinical cancer in non-diagnosed cases is suspected, we should be more aggressive for early diagnosis.Publication Metadata only Evaluation of CD47 Expression in Solid Pancreatic Tumors Diagnosed with Endosonography Guided Fine Needle Aspiration Biopsy(2022-01-01T00:00:00Z) ÜNVER, NURCAN; ÇOBAN, GANİME; ŞAHİN, NURHAN; GÜCİN, ZÜHAL; ARICI, DİLEK SEMA; ŞENTÜRK, HAKAN; ÇOBAN, GANİME; ŞAHİN, NURHAN; GÜCİN, ZÜHAL; ŞENTÜRK, HAKANPublication Metadata only Ovarian Granulosa Cell Tumor: A Clinicoradiologic Series with Litera- ture Review(2021-01-01T00:00:00Z) Kilinc, Yagmur Basak; Sari, Lutfullah; Toprak, Huseyin; Karabulut, Ummuhan Ebru; ŞAHİN, NURHAN; GÜLTEKİN, MEHMET ALİ; ŞAHİN, NURHANBackground: Ovarian granulosa cell tumors that originate from the sex cord-stromal cells represent 2% to 5% of all ovarian cancers. These tumors constitute two subgroups according to their clinical and histopathological features: juvenile granulosa cell tumors (JGCT) and adult granulosa cell tumors (AGCT). Granulosa cell tumor (GCT) is considered to be a low-grade malignancy with a favorable prognosis. Methods: This case series includes four patients who were admitted to our university hospital and had an MRI examination within 5 years. Results: The histopathological subtype of granulosa tumor was the adult type in 3 patients and juvenile type in 1 patient. Even though it is extremely rare, bone metastases were present in one of our patients. Liver metastases were also detected in one patient. The MRI examination of tumors revealed a heterogeneous solid mass that contained cystic components in 3 patients. In one of our patients, the tumor had a multiseptated cystic feature, and all of the tumors were ovoid or round with smooth margins. T1 signal hyperintensity, not suppressed on fat saturation sequences, was observed in 3 patients, which represents its hemorrhagic content. Conclusion: Even though granulosa cell tumor shows a wide spectrum in terms of tumor appearance, some common findings have been shown and especially a hemorrhagic content could be a clue for us. The tumor is known to have a good prognosis, but it may have an unpredictable clinical course, so close follow-up is greatly important.Publication Metadata only Esophageal inlet patch: Demographic and endoscopic characteristics of patients and review of the literature(2021-08-01T00:00:00Z) KÖKER, İBRAHİM HAKKI; ŞAHİN, NURHAN; KÖKER, İBRAHİM HAKKI; ŞAHİN, NURHANPublication Open Access Expression of transient receptor potential melastatin 4 in differential diagnosis of eosinophilic renal tumors(2021-11-01T00:00:00Z) ÇOBAN, GANİME; YILDIZ, PELİN; DOĞAN, BAYRAM; ŞAHİN, NURHAN; GÜCİN, ZÜHAL; ÇOBAN, GANİME; YILDIZ, PELİN; DOĞAN, BAYRAM; ŞAHİN, NURHAN; GÜCİN, ZÜHALImmunohistochemical and molecular studies to differentiate eosinophilic kidney tumors are gradually increasing. The present study investigated the role of transient receptor potential cation channel subfamily M member 4 (TRPM4), a non-selective cation channel associated with migration, proliferation and invasion in cancer cells, in this differentiation. The aim was to investigate the effectiveness of TRPM4 in differentiation of eosinophilic kidney tumors. The study included a total of 112 patients, including 97 eosinophilic kidney tumors with the diagnoses of 33 eosinophilic clear cell renal cell carcinoma (CCRCC), 35 eosinophilic chromophobe renal cell carcinoma (ChRCC), 8 papillary renal cell carcinoma type 2 (P2RCC), 21 renal oncocytoma (RO), as well as 15 papillary renal cell carcinoma type 1 to differentiate from P2RCC. For TRPM4, diffuse staining (>10%) was observed in 2 CCRCC, 15 ChRCC, 20 RO and 4 P2RCC cases. There was a significant difference between eosinophilic CCRCC and other eosinophilic tumors (P<0.05). While basolateral staining was observed in papillary tumors, membrane staining was observed in other stained cases. It was hypothesized that the use of TRPM4 along with morphological findings, cytokeratin 7 and other markers may be useful for the differentiation of eosinophilic kidney tumors.Publication Metadata only Mmp-9 and Fascin-1 Expression in Endometrioid-Type Endometrial Carcinoma and Their Prognostic Value(2021-03-01T00:00:00Z) TECELLİOĞLU, FAHRİYE SEÇİL; AKPOLAT, NUSRET; ŞAHİN, NURHAN; ŞAHİN, NURHANBackgrounds Matrix metalloproteinases (MMP) and fascin-1 play roles in epithelial-mesenchymal transition and tumour invasion. Aims This study was performed to investigate the relationships of fascin-1 and MMP-9 expression with prognostic parameters in endometrioid-type endometrial carcinoma (EEC). Methods A total of 100 cases of EEC were included in the study. Tissues were stained with antibodies against fascin-1 and MMP-9. The relationships between the immunohistochemical findings and clinicopathological prognostic parameters of EEC were examined. Results Tumour diameter was significantly related to lymphovascular invasion, FIGO stage and FIGO grade (p 2 cm was associated with a poor prognosis. The staining score for fascin-1 was 5 in 19 cases (p > 0.05), and that for MMP-9 was 5 in 61 cases (p > 0.05). Neither fascin-1 nor MMP-9 expression was significantly related to any of the clinicopathological parameters examined. Conclusion There were no significant relationships of fascin-1 and MMP-9 expression with the clinicopathological parameters of EEC. The results of this study suggested that these molecules do not contribute to the clinical behaviour of EECs. A tumour size > 2 cm is associated with a poor prognosis in EEC patients. To verify these results, more studies are needed with larger patient groups.Publication Metadata only Recurrent angiolymphoid hyperplasia with eosinophilia during several pregnancies.(2020-08-15T00:00:00Z) Cenk, Hulya; Kapicioglu, Yelda; Sarac, Gulbahar; Sener, Serpil; Sahin, NURHAN; ŞAHİN, NURHANPublication Metadata only Significance of CD47 expression in endometrial carcinoma(2022-06-01T00:00:00Z) Şahin, Nurhan; Çoban, Ganime; Ünver, Nurcan; Arıcı, Dilek S.; Kılıc, Gökhan; Toluk, Özlem; ŞAHİN, NURHAN; ÇOBAN, GANİME; KILIC, GÖKHAN; TOLUK, ÖZLEMPublication Metadata only The Effect of Bemiparine Na and Hyaluronic Acid on Postoperative Adhesions in Rat Uterine Horn Model(2022-03-14) Baydemir S.; Gökmen Karasu A. F.; Turna S.; Şahin N.; GÖKMEN KARASU, AYŞE FİLİZ; TURNA, SEVAL; ŞAHİN, NURHANPublication Metadata only Unexpected Discoveries: Uncovering Incidental Tumors in Simple Nephrectomy Specimens(2023-11-01) Çoban G.; Coşanay Tekden B.; Şahin N.; Toluk Ö.; Toprak H.; Yıldız P.; İlktaç A.; ÇOBAN, GANİME; COŞANAY TEKDEN, BÜŞRA; ŞAHİN, NURHAN; TOLUK, ÖZLEM; TOPRAK, HÜSEYİN; İLKTAÇ, ABDULLAH