Person: ÖZTÜRK CİVELEK, DİLEK
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Publication The Association of ABCC5 and ABCC11 Polymorphisms with The Pharmacokinetics of 5-FU in Advanced Gastric Cancer Patients(2020-09-01T00:00:00Z) Akyel, Yasemin Kübra; Pala Kara, Zeliha; Öztaş, Ezgi; Öztürk, Dilek; Turna, Zeynep Hande; Okyar, Alper; Özhan, Gül; ÖZTÜRK CİVELEK, DİLEKPublication SS-73: Everolimusun kronofarmakokinetiği: Uygulama zamanı, cinsiyet ve beslenme durumunun etkisi(2019-11-03T00:00:00Z) Öztürk, Ferdi; ÖZTÜRK, DİLEK; Yasemin Kübra, Akyel; PALA KARA, ZELİHA; OKYAR, ALPER; ÖZTÜRK CİVELEK, DİLEKPublication Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies(2019-12-01) ZENGİN KURT, BELMA; SÖNMEZ, FATİH; ÖZTÜRK, DİLEK; AKDEMİR, ATİLLA; Angeli, Andrea; Supuran, Claudiu T; ZENGİN KURT, BELMA; ÖZTÜRK CİVELEK, DİLEK; AKDEMİR, ATİLLAPublication P-glikoprotein substratı talinololün dişi ve erkek farelerdeki farmakokinetiği(2015-09-10) Öztürk, Dilek; Pala Kara, Zeliha; Okyar, Alper; ÖZTÜRK CİVELEK, DİLEKPublication Dosing-time dependent testicular toxicity of everolimus in mice.(2021-07-07T00:00:00Z) Ozturk, Narin; Ozturk Civelek, DİLEK; Sancar, Serap; Kaptan, Engin; Pala Kara, Zeliha; Okyar, Alper; ÖZTÜRK CİVELEK, DİLEKPublication Synthesis and Cytotoxic Activity of New Sorafenib / Ruthenium Complexes,(2020-02-27T00:00:00Z) Zengin Kurt, Belma; Çakma, Elmas Begüm; Öztürk, Dilek; Dağ, Aydan; Benkli, Kadriye; ZENGİN KURT, BELMA; ÖZTÜRK CİVELEK, DİLEK; DAĞ, AYDANPublication Evaluation of Metabolites Produced by Fungal Biotransformation of Apigenin and Fisetin and Their Cytotoxic Activities(2020-03-01T00:00:00Z) GAZİOĞLU, IŞIL; Erdoğan, Oğuz; YANIKOĞLU, RABİA SARE; ÖZTÜRK, DİLEK; GAZİOĞLU, IŞIL; YANIKOĞLU, RABİA SARE; ÖZTÜRK CİVELEK, DİLEKPublication The immune system as a chronotoxicity target of the anticancer mTOR inhibitor everolimus.(2018-05-01) OZTURK, N; Ozturk, DİLEK; PALA-KARA, Z; KAPTAN, E; SANCAR-BAS, S; OZSOY, N; CINAR, S; DENIZ, G; LI, XM; GIACCHETTI, S; LÉVI, F; OKYAR, A; ÖZTÜRK CİVELEK, DİLEKPublication Dosing-time, feeding, and sex-dependent variations of everolimus pharmacokinetics in mice(2024-01-01) ÖZTÜRK CİVELEK D.; ÖZTÜRK SEYHAN N.; AKYEL Y. K.; Gazioglu I.; PALA KARA Z.; Orman M. N.; OKYAR A.; ÖZTÜRK CİVELEK, DİLEK; GAZİOĞLU, IŞILBackground: Everolimus is an oral mammalian target of rapamycin (mTOR) inhibitor used as an immunosuppressant and anticancer. Its pharmacokinetics is highly variable, it has a narrow therapeutic window and shows chronotoxicity with the best time at ZT13 and worst time at ZT1 (ZT; Zeitgeber time, time after light onset) in the preclinical setting. Objectives: In the present study, we aimed to investigate whether the pharmacokinetics of everolimus vary according to dosing time and whether sex and feeding status interfere with the chronopharmacokinetics. Method: A single dosage of 5 mg/kg everolimus was administered orally to C57BL/6J male and female mice, in fed or fasted states at ZT1-rest and ZT13-activity times and blood and tissue samples were collected at 0.5, 1, 2, 4, 12, and 24 h following drug administration. Ileum, liver, plasma, and thymus concentrations of everolimus were determined. Results: Females had a greater ileum AUC0–24h than males when fed (P = 0.043). Everolimus AUC0–24h in the liver was substantially greater at ZT1 than at ZT13 in a fasted state (P = 0.001). Plasma Cmax, AUC0–24h, and AUCtotal were not statistically significant between the groups (P = 0.098). In one of the target organs of everolimus, the thymus, males had considerably higher amounts at ZT1 than females (P = 0.029). Conclusion: Our findings imply that the pharmacokinetics of everolimus in mice may differ according to dosing time, sex, and feeding. Greater tissue distribution of everolimus at ZT1 may be associated with the worst tolerated time of everolimus. Our research suggests that oral chronomodulated everolimus therapy may be more effective and safer for cancer patients.Publication Synthesis and Cytotoxic Activity of Coumarin-Thymol Derivatives(2018-06-30) ZENGİN KURT, BELMA; Çelebi, Gülşen; ÖZTÜRK, DİLEK; SONMEZ, FATIH; ZENGİN KURT, BELMA; ÖZTÜRK CİVELEK, DİLEK