Person: SEYİTHANOĞLU, MEHMET HAKAN
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Publication malign orta serebral arter iskemik inmelerinde dekompresif hemikraniektomi:Bezmialem üniversitesi yaklaşımı(2017-04-02) dündar, tolga turan; SEYİTHANOĞLU, MEHMET HAKAN; kitiş, serkan; GÜNDAĞ PAPAKER, MELİHA; özek, erdinç; TEKİN, ABDURRAHİM; HATİBOĞLU, MUSTAFA AZİZ; SEYİTHANOĞLU, MEHMET HAKAN; TEKİN, ABDURRAHIM; HATİBOĞLU, MUSTAFA AZİZPublication VENTRİKÜLO-PERİTONEAL ŞANTIN GEÇ KOMPLİKASYONU: DÖRT OLGUDA PERİTONEAL KATETERİN ANAL PROLAPSUSU(2011-04-26) SEYİTHANOĞLU, MEHMET HAKAN; GUNDAG, MELİHA; DOGAN, KAZIM; KİTİŞ, SERKAN; öztürk, şeref; DÜNDAR, TOLGA TURAN; Çevik, Serdar; SEYİTHANOĞLU, MEHMET HAKAN; GUNDAG, MELİHA; KİTİŞ, SERKAN; DÜNDAR, TOLGA TURANPublication Investigation of Brain Impairment Using Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Imaging in Experienced Healthy Divers.(2018-11-17) SEYITHANOĞLU, MEHMET HAKAN; ABDALLAH, ANAS ABDELRAHIM SA; Dündar, TOLGA TURAN; KITIŞ, SERKAN; ARALAŞMAK, AYŞE; Gündağ, Papaker; SASANI, H; SEYİTHANOĞLU, MEHMET HAKAN; ABDALLAH, ANAS ABDELRAHıM SA; DÜNDAR, TOLGA TURAN; KİTİŞ, SERKAN; ARALAŞMAK, AYŞE; GUNDAG, MELİHABackground: The aim of this study was to understand the changes of decompression illness in healthy divers by comparing diffusion-weighted (DWI) and diffusion tensor MRI findings among healthy professional divers and healthy non-divers with no history of diving. Material/Methods: A total of 26 people were recruited in this prospective study: 11 experienced divers with no history of neurological decompression disease (cohort) and 15 healthy non-divers (control). In all study subjects, we evaluated apparent diffusion coefficient (ADC) and type of diffusion tensor metric fractional anisotropy (FA) values of different brain locations (e.g., frontal and parieto-occipital white matter, hippocampus, globus pallidus, putamen, internal capsule, thalamus, cerebral peduncle, pons, cerebellum, and corpus callosum). Results: ADC values of hippocampus were high in divers but low in the control group; FA values of globus pallidus and putamen were lower in divers compared to the control group. DWI depicted possible changes due to hypoxia in different regions of the brain. Statistically significant differences in ADC values were found in hypoxia, particularly in the hippocampus (p=0.0002), while FA values in the globus pallidus and putamen were statistically significant (p=0.015 and p=0.031, respectively). We detected forgetfulness in 6 divers and deterioration in fine-motor skills in 2 divers (p=0.002 and p=0.17, respectively). All of them were examined using neuro-psychometric tests. Conclusions: Repeated hyperbaric exposure increases the risk of white matter damage in experienced healthy divers without neurological decompression illness. The hippocampus, globus pallidus, and putamen are the brain areas responsible for memory, learning, navigation, and fine-motor skills and are sensitive to repeated hyperbaric exposurePublication Beyin metastazlı hastalarda gamma knife radiocerrahisinin ve tüm beyi ışınlamasının immün sistem ilişkili proteinlwer üzerine etkilerinin incelenmesi(2018-04-20) KOÇYİĞİT, ABDURRAHİM; HATİBOĞLU, MUSTAFA AZİZ; GÜLER, ERAY METİN; nallı, arife; akdur, kerime; şakarcan, ayten; özek, erdinç; BULUT, HURİ; MAYADAĞLI, ALPASLAN; SEYİTHANOĞLU, MEHMET HAKAN; HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; MAYADAĞLI, ALPASLAN; SEYİTHANOĞLU, MEHMET HAKANPublication C6 Glioma Hücre Kültüründe Timokinon’un Etkinliğinin Araştırılması(2017-04-02T00:00:00Z) ŞİŞMAN, BEHİCE HANDE; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; SEYİTHANOĞLU, MEHMET HAKAN; HATİBOĞLU, MUSTAFA AZİZ; ŞİŞMAN, BEHİCE HANDE; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; SEYİTHANOĞLU, MEHMET HAKAN; HATİBOĞLU, MUSTAFA AZİZPublication The Effectiveness of Hyperbaric Oxygen Therapy in an Established Intracerebral Tumor Model(2015-07-01) DÜNDAR, TOLGA TURAN; SEYİTHANOĞLU, MEHMET HAKAN; KORPINAR, ŞEFİKA; ATAR, RAZİYE; EVRAN, ŞEVKET; DÜNDAR, TOLGA TURAN; SEYİTHANOĞLU, MEHMET HAKANObjective: Gliomas are the most common brain tumor in adults. Tumor-related endothelial cells are of neoplastic nature and have malignant properties such as proliferation and invasion. Therefore, antiangiogenic approaches have several advantages compared with conventional chemotherapeutic approaches. The target of antiangiogenic treatment is to ensure a decrease in systemic side effects because there are endothelial cells and other supportive cells belonging to the vessel walls. The purpose of this study was to increase the oxygenation of the environment with hyperbaric oxygen therapy (HBOT) and to prevent the angiogenic effect of hypoxia- related factors. We also tried to prevent angiogenesis by using sorafenib (SOR), which is a chemotherapeutic agent that blocks the receptors of these factors. Also, this study compared the effect of these both and to put into for their effect. In this regard, parameters such as the tumor size, vascularization rate, midkine (MK), apoptosis- and angiogenesis-related transcription tumor necrosis factor (TNF) alfa, and IL6 were compared in the relevant groups. Methods: For this purpose, a convenient trial model was formed and the following 4 groups were determined: The study population was divided into four main groups: G1-control group, G2-group given HBOT, G3-group given SOR, G4-group given HBOT and SOR. Ten rats were included in each group. After 2 weeks, the rats were sacrificed. After being sacrificed based on the date and surgery determined, the tumor volume and vascularization ratio were checked with light microscope. Serum samples are evaluated by using ELISA for TNF-alpha, Interleukin-6 (IL- 6) and midkine (MK) levels. Results: The underlying mechanism of HBOT by evaluating MK levels was shown for the first time in this study. We have found that HBOT potentializes the sorafenib efficacy. HBOT increased MK levels and HBOT decreased anti-apoptotic TNF-α and IL-6 levels. MK levels show inverse correlation with TNF-α levels and IL-6 levels. TNF-α and IL-6 levels are directly proportional. Conclusion: There is a need for further studies to evaluate the correct time of application of HBOT.Publication YÜKSEK GRADE’Lİ GLIAL TÜMÖRLERDE YERLEŞIM YERI, YAŞ VE CINSIYET DAĞILIMLARI: SON IKI YILA AIT BEZMIALEM SONUÇLARI(2018-04-20T00:00:00Z) dündar, tolga; TEKİN, ABDURRAHİM; YAPAR, SELÇUK; GÖNEN, GÜVEN; Abdallah, Anas; KİTİŞ, SERKAN; özek, erdinç; GÜNDAĞ PAPAKER, MELİHA; SEYİTHANOĞLU, MEHMET HAKAN; HATİBOĞLU, MUSTAFA AZİZ; TEKİN, ABDURRAHIM; YAPAR, SELÇUK; GÖNEN, GÜVEN; SEYİTHANOĞLU, MEHMET HAKAN; HATİBOĞLU, MUSTAFA AZİZPublication Comparison of TOF MRA, Contrast-Enhanced MRA and Subtracted CTA from CTP inResidue Evaluation of Treated Intracranial Aneurysms(2017-11-10T00:00:00Z) DÜNDAR, TOLGA TURAN; SEYİTHANOĞLU, MEHMET HAKAN; ARALAŞMAK, AYŞE; Toprak, Huseyin; Kitiş, Serkan; Ozek, Erdinc; UYSAL, ÖMER; ALKAN, ALPAY; DÜNDAR, TOLGA TURAN; SEYİTHANOĞLU, MEHMET HAKAN; ARALAŞMAK, AYŞE; UYSAL, ÖMER; ALKAN, ALPAYPublication NÖROFİBROMATOZİS TİP-1’Lİ BİR HASTADA EKZOFİTİK DEV HÜCRELİ GLİOBLASTOMA: OLGU SUNUMU(2017-04-02) GUNDAG, MELİHA; KİTİŞ, SERKAN; SEYİTHANOĞLU, MEHMET HAKAN; DÜNDAR, TOLGA TURAN; GUNDAG, MELİHA; KİTİŞ, SERKAN; SEYİTHANOĞLU, MEHMET HAKAN; DÜNDAR, TOLGA TURANPublication Early Clinical Outcome and Complications of The Patients Who Underwent Instrumented Transforminal Lumbar Interbody Fusion (TLIF) With Autograft Bone(2019-04-14T00:00:00Z) ABDALLAH, ANAS ABDELRAHIM SALEH; ÖZEK, ERDİNÇ; SEYİTHANOĞLU, MEHMET HAKAN; GÜNDAĞ PAPAKER, MELİHA; DÜNDAR, TOLGA TURAN; HATİBOĞLU, MUSTAFA AZİZ; SEYİTHANOĞLU, MEHMET HAKAN; HATİBOĞLU, MUSTAFA AZİZ