Person: KYIO, NANG HSENG
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Publication Optimisation of Centrifugal Speed for PRPBAG (R): A Novel Multiple Bag System for Preparing Platelet-Rich Plasma(2021-07-01T00:00:00Z) ÇETİN, GÜVEN; KYIO, NANG HSENG; Turgut, Seda; ÖZKAN TEKİN, Tuba; ÇETİN, GÜVEN; KYIO, NANG HSENGObjective: This study aimed to identify the optimal centrifugal speed for the preparation of platelet-rich plasma (PRP) with PRPBAG (R), a novel multi-bag system. Methods: The study included 120 (60 women and 60 men) clinically healthy volunteers aged 18-35 years. Participants were divided into three age-sex matched groups according to the centrifugation speeds as follows: 1600 rpm (n=40), 1800 rpm (n=40) or 2000 rpm (n=40). Whole blood (150 mL) was drawn from the volunteers, and centrifugation was performed for 10 minutes. After the first spin, the erythrocytes precipitated in the first bag, and the supernatant plasma was transferred into the second bag. Plasma centrifugation was performed at 3500 rpm for 15 minutes. The high-quality PRP product precipitated in the second bag. The supernatant plateletpoor plasma was transferred to the third bag and destroyed. Blood cell count of whole blood and PRP product was measured. Results: The mean white blood cell level of PRP in the 1800 rpm group was higher than the other groups (p=0.027). The mean platelet levels were 1005.22 +/- 105.96, 1743.7 +/- 145.2 and 1743.7 +/- 145.2 103/uL in the 1600, 1800 and 2000 rpm groups, respectively, after centrifugation (p<0.001). Accordingly, the platelet yield (fold increase) was significantly greater in the 1800 rpm group than in the other groups (p<0.001). Conclusion: This study showed that 1800 rpm for 10 minutes is the optimum first centrifugation speed for preparing PRP with PRPBAG (R), as it provides an approximately eightfold increase in platelet concentration in PRPBAG (R)Publication Evolution of Hematological Parameters During the First 2 Years After Laparoscopic Sleeve Gastrectomy: Results of a Retrospective Study(2020-07-01T00:00:00Z) KYIO, NANG HSENG; Turgut, Seda; ÖZKAN TEKİN, Tuba; ÇETİN, GÜVEN; KYIO, NANG HSENG; ÇETİN, GÜVENPurpose Laparoscopic sleeve gastrectomy (LSG) is one of the most effective bariatric surgery methods of treatment for obesity. It can cause nutritional deficiencies and lead to anemia at the same time. The aim of the present study is to retrospectively investigate whether the supplement treatment administration to cases that underwent LSG is sufficient in terms of the hematological parameters. Material and Methods A total of 494 obese patients between 18 and 65 years who underwent LSG were recruited to the study. Vitamin B12, iron, and folic acid replacement therapy are prescribed to all patients who can be followed-up at regular intervals. We compared hemogram, iron studies, vitamin B12, and folic acid values of these patients at preoperative and at first visit (1 month), 3, 6, 12, and 24 months post-surgery. Results The number of patients with anemia and vitamin B12 and folic acid deficiencies decreased significantly during the follow-up with supplementation. Postoperative leucocyte and thrombocyte levels were significantly lower than the preoperative levels. Conclusion Our study indicates that the proper supplementation therapy in patients attending regular follow-up helps to keep hematological parameters within the normal range and to improve anemia and deficiencies of vitamin B12 and folic acid. Compliance with follow-up programs is essential after costly and invasive treatments such as sleeve gastrectomy to improve the well-being of patients in the long-term and to maximize compliance.Publication Case of BRAF mutant Erdheim-Chester disease presenting with multisystem involvement: A case report(2021-02-01T00:00:00Z) Karatoprak, Cumali; Kyıo, Nang Hseng; Kıran, Tuğçe; Eser, Ali; Çetin, Güven; KYIO, NANG HSENG; KIRAN, TUĞÇE; ÇETİN, GÜVEN; KARATOPRAK, CUMALİ