Person: KOÇYİĞİT, ABDÜRRAHİM
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Publication Metadata only Beta-globin gene mutations in children with beta-thalassemia major from Sanliurfa province, Turkey(2011-12-01T00:00:00Z) Aycicek, Ali; Koc, Ahmet; Ozdemir, Zeynep Canan; Bilinc, Hasan; Kocyigit, ABDÜRRAHİM; Dilmec, Fuat; KOÇYİĞİT, ABDÜRRAHİMObjective: The prevalence of (beta-thalassemia in Sanhurfa province, Turkey is reported to be 2.6%-3.7%, whereas nation-wide the frequency of beta-thalassemia is 2%. This study aimed to identify the most frequent beta-thalassemia mutations in Sanhurfa province.Publication Open Access Circulating levels of cytokines are increased in restless legs syndrome.(2020-10-21T00:00:00Z) Uslu, FI; Koçyiğit, A; Demir, E; Güler, Eray Metin; USLU, FERDA; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMBackground: Restless legs syndrome [RLS] is known as a disease of iron and dopaminergic dysregulation but inflammatory processes might also have a role in the pathogenesis. In this study, we compared the circulating levels of hsCRP, IL-1β, IL-6, and TNF-α in patients with primary restless legs syndrome [RLS] and healthy control subjects. Methods: We prospectively included 29 patients with primary RLS and 65 healthy controls [HC], all age-sex matched. The diagnosis of RLS was established using international guidelines. IRLSSG Severity Scale was used to evaluate the severity of RLS. Plasma levels of hsCRP, IL-1β, IL-6, and TNF-α were measured in all participants. Results: The mean age of patients was 37.8 ± 11.3 and 52% of RLS group were women. Serum IL-1β, IL-6, and TNF-α levels of the patient group were statistically significantly higher compared to HC [p < 0.001 for all variables]. Plasma levels of hsCRP did not differ between groups. There were 8 patients with mild RLS [28%], 13 patients with moderate RLS [45%], and 8 patients with severe RLS [28%]. Only IL-6 values were significantly different between the groups. In the severe group, the value of IL-6 was significantly higher than in the other groups [p: 0.03]. Conclusion: These results showing higher circulating levels of inflammatory cytokines in patients with RLS support the notion that inflammation may be involved in the pathogenesis of primary RLS. However, it is necessary to perform further studies to determine if this finding is a cause or an effect.Publication Metadata only Assessment of atherosclerosis in obese adolescents: Positive correlation of mean platelet volume and carotid intima media thickness(2013-11-01T00:00:00Z) Arslan, Nur; Makay, Balahan; Hizli, Samil; KOÇYİĞİT, ABDÜRRAHİM; Demircioglu, Fatih; Tuncel, Alpaslan Sedat; Cakmakci, Handan; KOÇYİĞİT, ABDÜRRAHİMAims: This study aims to assess the correlation of mean platelet volume (MPV) and common carotid artery (CCA) thickness in a population of obese adolescents.Publication Metadata only NF-?B Inhibition Activity of Curcumin-Loaded Sterically Stabilized Micelles and Its Up-Regulator Effect on Enhancement of Cytotoxicity of a New Nano-Pirarubicin Formulation in the Treatment of Breast Cancer(2019-01-01) Eskandari, Zahra; BAHADORİ, FATEMEH; Altikatoglu, Melda; YENİGÜN, VİLDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; Onyuksel, Hayat; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access Diagnostic potential of Brucella melitensis Rev1 native Omp28 precursor in human brucellosis(2018-01-01) Koyuncu, Ismail; Kocyigit, ABDÜRRAHİM; Ozer, Ahmet; SELEK, Sahabettin; Kirmit, Adnan; Karsen, Hasan; KOÇYİĞİT, ABDÜRRAHİM; SELEK, ŞAHABETTİNSerologic tests for brucellosis aim to detect antibodies produced against membranous lipopolysaccharide of bacteria. Diagnostic use of this method is limited due to false positiveness. This study evaluates an alternative antigen to lipopolysaccharides (LPS), outer membrane 28-precursor-protein, of Brucella melitensis Rev1 for its diagnostic value. Omp28 precursor of B. melitensis Rev1 was cloned, expressed, and purified. 6-His and sumo epitope tags were used to tag the protein at N-termini. Omp28 gene was amplified based on the ORF sequence and cloned into a pETSUMO vector. The recombinant construct was propagated in Escherichia coli One Shot® Mach1™ cells then transformed into E. coli BL21(D3) cells for protein expression. The purified protein was studied in an indirect ELISA for diagnosis of brucellosis. Sera samples from 60 patients were screened by ELISA and the results were compared to Rose Bengal plate test. Recombinant antigen-based iELISA has given a successful outcome with the sensitivity, specificity, positive predictive value, and negative predictive value of 87.8%, 96.2%, 96.6%, and 78.78%, respectively. In conclusion, recombinant production and purification of the immunodominant Omp28 precursor protein has been achieved successfully in a one-step process with efficient yield and can be used for diagnosis of brucellosis in humansPublication Metadata only Parental anxiety and affecting factors in acute paediatric blunt head injury(2014-01-01T00:00:00Z) Serinken, Mustafa; Kocyigit, ABDÜRRAHİM; Karcioglu, O.; Sengül, C.; Hatipoǧlu, C.; Elicabuk, H.; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Effectiveness of Different Surgical Flap Delay Methods and Their Systemic Toxicities.(2021-01-14T00:00:00Z) Yildiz, Kemalettin; Mirapoglu, Semih Lutfi; Kilic, Ulkan; Guneren, Ethem; Kocyigit, ABDÜRRAHİM; Kirazoglu, Ahmet; Sagir, Haci Omer; Yesiloglu, Nebil; Canter, Halil Ibrahim; Cay, Ali; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Oxidant-Antioxidant Balance in the Aqueous Humor of Patients with Retinal Vein Occlusion.(2018-01-01) Altinisik, M; Koytak, A; ELBAY, AHMET; TOKLU, E; SEZER, TAHA; KOCYIGIT, ABDÜRRAHİM; KOYTAK, İBRAHİM ARİF; ELBAY, AHMET; SEZER, TAHA; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Cytotoxic, genotoxic and apoptotic activities of carvacrol from Thymus vulgaris on the human adenocarcinoma gastric cells(2015-08-01) GUNES-BAYIR, Ayse; Kiziltan, HURİYE ŞENAY; Guler, ERAY METİN; KARAKAS, Ersin; Kocyigit, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access Serum obestatin and omentin levels in patients with diabetic nephropathy(2017-02-01) ZORLU, MEHMET; KISKAC, MUHARREM; Gueler, ERAY METİN; GUELTEPE, I.; YAVUZ, E.; CELIK, K.; KOCYIGIT, ABDÜRRAHİM; ZORLU, MEHMET; KISKAÇ, MUHARREM; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMIntroduction: Diabetic nephropathy is the leading cause of chronic kidney disease and accounts for almost 45% of all new patients requiring renal replacement therapy. Omentin and obestatin, two novel proteins were suggested to be associated with insulin resistance, type 2 diabetes and cardiovascular risk factors. Thus, we postulated that they may also have an association with diabetic nephropathy which is known to be an independent cardiovascular risk factor. In order to investigate such an association we compared serum omentin and obestatin levels in type 2 diabetic patients with normoalbuminuria (NA) and macroalbuminuria (MA). Materials and Methods: A total of 81 type 2 diabetic patients were separated into two groups according to their proteinuria status; patients with NA (n = 39) and patients with MA (n = 42). Two groups were compared in terms of serum omentin and obestatin levels. Results: While serum omentin levels did not differ among two groups (P = 0.407), serum obestatin levels were significantly higher in MA group (P = 0.001). Conclusion: The results of this study showed that higher serum levels of obestatin were associated with macro albuminuria suggesting that obestatin may have a role in underlying pathogenic mechanisms that leads to diabetic nephropathy