Person: KOÇYİĞİT, ABDÜRRAHİM
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Publication Metadata only Timokinon İle İndüklenmiş Gastrik Adenokarsinom Hücrelerinde Sitotoksisite, Genotoksisite ve Apoptoz(2015-11-06T00:00:00Z) GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Beta-globin gene mutations in children with beta-thalassemia major from Sanliurfa province, Turkey(2011-12-01T00:00:00Z) Aycicek, Ali; Koc, Ahmet; Ozdemir, Zeynep Canan; Bilinc, Hasan; Kocyigit, ABDÜRRAHİM; Dilmec, Fuat; KOÇYİĞİT, ABDÜRRAHİMObjective: The prevalence of (beta-thalassemia in Sanhurfa province, Turkey is reported to be 2.6%-3.7%, whereas nation-wide the frequency of beta-thalassemia is 2%. This study aimed to identify the most frequent beta-thalassemia mutations in Sanhurfa province.Publication Metadata only Oleuropein mide kanserine karşı: Yeni Tedavi Umudu(2018-11-20T00:00:00Z) TÜRKDOĞAN, KÜRŞAD; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; ÖZER, ÖMER FARUKPublication Metadata only Cytotoxic and apoptotic activities of thymol from Thymus vulgaris on the human gastric adenocarcinoma cells(2015-06-10) GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KARAKAŞ, ERSİN; KOÇYİĞİT, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Assessment of atherosclerosis in obese adolescents: Positive correlation of mean platelet volume and carotid intima media thickness(2013-11-01T00:00:00Z) Arslan, Nur; Makay, Balahan; Hizli, Samil; KOÇYİĞİT, ABDÜRRAHİM; Demircioglu, Fatih; Tuncel, Alpaslan Sedat; Cakmakci, Handan; KOÇYİĞİT, ABDÜRRAHİMAims: This study aims to assess the correlation of mean platelet volume (MPV) and common carotid artery (CCA) thickness in a population of obese adolescents.Publication Metadata only Çocukluk çağı kronik idiyopatik ürtikerinde plazma tiyol dengesi ve hastalık ağırlığı ilişkisi(2018-04-23) Dilek, Fatih; ÖZÇEKER, DENİZ; ÖZKAYA, EMİN; GÜLER, ERAY METİN; TAMAY, ZEYNEP ÜLKER; yazıcı, mebrure; KOÇYİĞİT, ABDÜRRAHİM; guler, nermin; ÖZKAYA, EMİN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Anti-Cancer Effect Of Urfa Pistachio (Pistacia Vera) Green Hull Extract On Colon Adenocarcinoma Cells(2016-10-30T00:00:00Z) KOYUNCU, İSMAİL; KOÇYİĞİT, ABDÜRRAHİM; Yüksekdağ, Özgür; GÜLER, ERAY METİN; GÖNEL, ATAMAN; KİRMİT, ADNAN; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Metadata only NF-?B Inhibition Activity of Curcumin-Loaded Sterically Stabilized Micelles and Its Up-Regulator Effect on Enhancement of Cytotoxicity of a New Nano-Pirarubicin Formulation in the Treatment of Breast Cancer(2019-01-01) Eskandari, Zahra; BAHADORİ, FATEMEH; Altikatoglu, Melda; YENİGÜN, VİLDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; Onyuksel, Hayat; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access Diagnostic potential of Brucella melitensis Rev1 native Omp28 precursor in human brucellosis(2018-01-01) Koyuncu, Ismail; Kocyigit, ABDÜRRAHİM; Ozer, Ahmet; SELEK, Sahabettin; Kirmit, Adnan; Karsen, Hasan; KOÇYİĞİT, ABDÜRRAHİM; SELEK, ŞAHABETTİNSerologic tests for brucellosis aim to detect antibodies produced against membranous lipopolysaccharide of bacteria. Diagnostic use of this method is limited due to false positiveness. This study evaluates an alternative antigen to lipopolysaccharides (LPS), outer membrane 28-precursor-protein, of Brucella melitensis Rev1 for its diagnostic value. Omp28 precursor of B. melitensis Rev1 was cloned, expressed, and purified. 6-His and sumo epitope tags were used to tag the protein at N-termini. Omp28 gene was amplified based on the ORF sequence and cloned into a pETSUMO vector. The recombinant construct was propagated in Escherichia coli One Shot® Mach1™ cells then transformed into E. coli BL21(D3) cells for protein expression. The purified protein was studied in an indirect ELISA for diagnosis of brucellosis. Sera samples from 60 patients were screened by ELISA and the results were compared to Rose Bengal plate test. Recombinant antigen-based iELISA has given a successful outcome with the sensitivity, specificity, positive predictive value, and negative predictive value of 87.8%, 96.2%, 96.6%, and 78.78%, respectively. In conclusion, recombinant production and purification of the immunodominant Omp28 precursor protein has been achieved successfully in a one-step process with efficient yield and can be used for diagnosis of brucellosis in humansPublication Metadata only Parental anxiety and affecting factors in acute paediatric blunt head injury(2014-01-01T00:00:00Z) Serinken, Mustafa; Kocyigit, ABDÜRRAHİM; Karcioglu, O.; Sengül, C.; Hatipoǧlu, C.; Elicabuk, H.; KOÇYİĞİT, ABDÜRRAHİM