Person: KOÇYİĞİT, ABDÜRRAHİM
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Publication Metadata only Timokinon İle İndüklenmiş Gastrik Adenokarsinom Hücrelerinde Sitotoksisite, Genotoksisite ve Apoptoz(2015-11-06T00:00:00Z) GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Toxicity of Sodium Fluoride in Adult Retinal Pigment Epithelial Cells Related to Transepithelial Resistance Mechanism(2020-03-17T00:00:00Z) Erkan, Muhammed Abdulkadir; UMURHAN AKKAN, JÜLİDE CANAN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; UMURHAN AKKAN, JÜLİDE CANAN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Oleuropein mide kanserine karşı: Yeni Tedavi Umudu(2018-11-20T00:00:00Z) TÜRKDOĞAN, KÜRŞAD; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; ÖZER, ÖMER FARUKPublication Metadata only Cytotoxic and apoptotic activities of thymol from Thymus vulgaris on the human gastric adenocarcinoma cells(2015-06-10) GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KARAKAŞ, ERSİN; KOÇYİĞİT, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access Circulating levels of cytokines are increased in restless legs syndrome.(2020-10-21T00:00:00Z) Uslu, FI; Koçyiğit, A; Demir, E; Güler, Eray Metin; USLU, FERDA; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMBackground: Restless legs syndrome [RLS] is known as a disease of iron and dopaminergic dysregulation but inflammatory processes might also have a role in the pathogenesis. In this study, we compared the circulating levels of hsCRP, IL-1β, IL-6, and TNF-α in patients with primary restless legs syndrome [RLS] and healthy control subjects. Methods: We prospectively included 29 patients with primary RLS and 65 healthy controls [HC], all age-sex matched. The diagnosis of RLS was established using international guidelines. IRLSSG Severity Scale was used to evaluate the severity of RLS. Plasma levels of hsCRP, IL-1β, IL-6, and TNF-α were measured in all participants. Results: The mean age of patients was 37.8 ± 11.3 and 52% of RLS group were women. Serum IL-1β, IL-6, and TNF-α levels of the patient group were statistically significantly higher compared to HC [p < 0.001 for all variables]. Plasma levels of hsCRP did not differ between groups. There were 8 patients with mild RLS [28%], 13 patients with moderate RLS [45%], and 8 patients with severe RLS [28%]. Only IL-6 values were significantly different between the groups. In the severe group, the value of IL-6 was significantly higher than in the other groups [p: 0.03]. Conclusion: These results showing higher circulating levels of inflammatory cytokines in patients with RLS support the notion that inflammation may be involved in the pathogenesis of primary RLS. However, it is necessary to perform further studies to determine if this finding is a cause or an effect.Publication Metadata only Çocukluk çağı kronik idiyopatik ürtikerinde plazma tiyol dengesi ve hastalık ağırlığı ilişkisi(2018-04-23) Dilek, Fatih; ÖZÇEKER, DENİZ; ÖZKAYA, EMİN; GÜLER, ERAY METİN; TAMAY, ZEYNEP ÜLKER; yazıcı, mebrure; KOÇYİĞİT, ABDÜRRAHİM; guler, nermin; ÖZKAYA, EMİN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Anti-Cancer Effect Of Urfa Pistachio (Pistacia Vera) Green Hull Extract On Colon Adenocarcinoma Cells(2016-10-30T00:00:00Z) KOYUNCU, İSMAİL; KOÇYİĞİT, ABDÜRRAHİM; Yüksekdağ, Özgür; GÜLER, ERAY METİN; GÖNEL, ATAMAN; KİRMİT, ADNAN; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Metadata only Investigation of Oxidative Stress and Inflammation in Restless Legs Syndrome(2020-03-17T00:00:00Z) Demir, Ervanur; USLU, FERDA; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; USLU, FERDA; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Cytotoxic, genotoxic and apoptotic activities of carvacrol from Thymus vulgaris on the human adenocarcinoma gastric cells(2015-08-01) GUNES-BAYIR, Ayse; Kiziltan, HURİYE ŞENAY; Guler, ERAY METİN; KARAKAS, Ersin; Kocyigit, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access Serum obestatin and omentin levels in patients with diabetic nephropathy(2017-02-01) ZORLU, MEHMET; KISKAC, MUHARREM; Gueler, ERAY METİN; GUELTEPE, I.; YAVUZ, E.; CELIK, K.; KOCYIGIT, ABDÜRRAHİM; ZORLU, MEHMET; KISKAÇ, MUHARREM; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMIntroduction: Diabetic nephropathy is the leading cause of chronic kidney disease and accounts for almost 45% of all new patients requiring renal replacement therapy. Omentin and obestatin, two novel proteins were suggested to be associated with insulin resistance, type 2 diabetes and cardiovascular risk factors. Thus, we postulated that they may also have an association with diabetic nephropathy which is known to be an independent cardiovascular risk factor. In order to investigate such an association we compared serum omentin and obestatin levels in type 2 diabetic patients with normoalbuminuria (NA) and macroalbuminuria (MA). Materials and Methods: A total of 81 type 2 diabetic patients were separated into two groups according to their proteinuria status; patients with NA (n = 39) and patients with MA (n = 42). Two groups were compared in terms of serum omentin and obestatin levels. Results: While serum omentin levels did not differ among two groups (P = 0.407), serum obestatin levels were significantly higher in MA group (P = 0.001). Conclusion: The results of this study showed that higher serum levels of obestatin were associated with macro albuminuria suggesting that obestatin may have a role in underlying pathogenic mechanisms that leads to diabetic nephropathy