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ZORLU, MEHMET

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MEHMET
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ZORLU
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Subject: restless legs syndrome ×

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    PublicationOpen Access
    Serum endocan levels in women with restless legs syndrome.
    (2015-11-19) CELIK, K; ÇıKRıKÇıOĞLU, MA; HALAC, G; KILIC, ERDEM; AYHAN, S; OZARAS, N; Karatoprak, CUMALİ; YILDIZ, KEMALETTİN; YILDIZ, RS; ZORLU, MEHMET; CAKIRCA, MUSTAFA; KıSKAÇ, MUHARREM; KILIÇ, ERDEM; YILDIZ, KEMALETTİN; ZORLU, MEHMET; KARATOPRAK, CUMALİ; ÇAKIRCA, MUSTAFA; KISKAÇ, MUHARREM
    Background: Endocan is a recently introduced marker of endothelial dysfunction. The objective of this study was to compare serum endocan levels in patients with restless legs syndrome (RLS) and control subjects in order to elucidate whether RLS is associated with endothelial dysfunction. Methods: A total of 31 drug naïve female patients with RLS and 31 age- and BMI-matched women were included in the study. Patients with pathological or physiological conditions or with a history of medication use that could potentially influence endothelial functions were excluded, as well as those with alcohol or drug abuse history. The two groups were compared with routine blood tests and serum endocan levels. Results: Patients with RLS had lower serum endocan levels than the controls (P=0.037). There was a negative bivariate correlation between RLS severity score and serum endocan levels (r=-0.406, P=0.023). While white blood cell count was significantly higher in RLS group, 25-hydroxy vitamin D3, vitamin B12, transferrin saturation rate, and HDL-cholesterol were significantly lower. Creatininemia and diastolic blood pressure were also marginally insignificantly lower in RLS group. Due to the presence of differences between two groups in these variables, a linear regression analysis was performed that showed a positive association between endocan and creatininemia (β=0.310, P=0.022), and a negative association between endocan and RLS (β=-0.502, P,0.001). Conclusion: The results of this study seem to suggest that patients with RLS may have better endothelial functions when compared with the general population and that these patients may be better protected against atherosclerosis
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    PublicationOpen Access
    Determining the Frequency of Restless Legs Syndrome in the Adult Population
    (2024-10-01) KISKAÇ N.; ZORLU M.; ZORLU, MEHMET
    Objective: Restless legs syndrome (RLS) is a chronic disease that usually occurs in the legs, resulting in involuntary movement of the legs with uncomfortable sensations. RLS negatively affects the quality of life of individuals. In this study, it is aimed to increase awareness by determining the frequency of RLS in the adult population. Methods: The study was a descriptive and cross-sectional study. In the study, 565 individuals aged 18 and over participated. The data were collected online from individuals with the form of describing the personal characteristics of the individuals, the RLS Diagnostic Criteria Questionnaire, and the RLS Severity Rating Scale. IBM SPSS statistics 26.0 program was used in the analysis of the data. Results: In this study, the frequency of RLS was 17.5% and the severity score was 19.22 +/- 6.97 (moderate). The rate of admitting to a health institution due to the symptoms of individuals is 5.8%. In this study, the frequency of RLS was found to be significantly higher in those with diabetes, hypertension, age, and high body mass index. Conclusion: Although most of the participants in this study had symptoms of RLS, it was seen that they were not admitted to a health institution. If these individuals are not treated, their quality of life gets affected negatively, and this negatively affects the quality of health care. In order to increase the quality of health care, RLS should be screened especially in risky groups and treatment should be started in determined patients.