Person: DEMİR, TARıK
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Publication Metadata only Serotonin-2A receptor and catechol-O-methyltransferase polymorphisms in panic disorder.(2012-01-10) KARACETIN, G; BAYOGLU, B; CENGIZ, M; DEMIR, TARIK; KOCABASOGLU, N; Uysal, O; BAYAR, R; BALCIOGLU, I; DEMİR, TARıK; UYSAL, ÖMERPublication Metadata only Clinicopathological features of gastroenteropancreatic neuroendocrine neoplasms: a retrospective single-center experience(2021-03-01T00:00:00Z) ŞEKERCİ, ABDÜSSELAM; TÜRK, HACI MEHMET; DEMİR, Tarık; ŞEKER, Mesut; AKÇAKAYA, Adem; ARICI, Dilek Sema; ŞEKERCİ, ABDÜSSELAM; TÜRK, HACI MEHMET; DEMİR, TARıK; ŞEKER, MESUT; AKÇAKAYA, ADEM; ARICI, DILEK SEMAPublication Open Access Evaluation of Kidney Function in Patients on Chemotherapy(2021-04-01T00:00:00Z) Haziyev, Elgun; GÜRSU, Meltem; ŞEKER, Mesut; ELÇİOĞLU, Ömer Celal; ARTAN, AYŞE SERRA; ALİYEV, Altay; TÜRK, HACI MEHMET; DEMİR, Tarık; TOPRAK, ALİ; KAZANCIOĞLU, Rümeyza; GÜRSU, MELTEM; ŞEKER, MESUT; ELÇİOĞLU, ÖMER CELAL; ARTAN, AYŞE SERRA; ALİYEV, ALTAY; TÜRK, HACI MEHMET; DEMİR, TARıK; TOPRAK, ALİ; KAZANCIOĞLU, RÜMEYZAObjective: We aimed to study whether long-term kidney function would be affected by different chemotherapy regimens in patients with malignancy.Publication Open Access Platelet to lymphocyte ratio is associated with tumor localization and outcomes in metastatic colorectal cancer(2021-11-01T00:00:00Z) Acikgoz, Ozgur; Cakan, Burcin; DEMİR, Tarık; Bilici, Ahmet; Oven, Bala Basak; Hamdard, Jamshid; Olmuscelik, Oktay; Olmez, Omer Fatih; ŞEKER, Mesut; Yildiz, Ozcan; DEMİR, TARıK; ŞEKER, MESUTThe aim of this study was to investigate the predictive and prognostic value of PLR, and the relationship between PLR and tumor localization. A total of 229 patients with de-novo metastatic CRC were retrospectively analyzed. The cutoff value for PLR was defined by the receiver operating characteristic (ROC) curve analysis and threshold value of 196.5 as best cut-off value was found. The higher rate of BRAF mutation was significantly detected for patients with PLRhigh (> 196.5) compared to those with PLRlow (<= 196.5) (P = .001). PLR was significantly higher in tumors located on the right colon (P = .012). PLR, tumor localization, the presence of surgery for primary tumor, the presence of curative surgery, the presence of metastasectomy for progression-free survival (PFS) and PLR, gender, BRAF mutation, tumor localization, the presence of surgery for primary tumor, the presence of metastasectomy for overall survival (OS) were found to be prognostic factors by univariate analysis. Multivariate analysis showed that PLR, the presence of curative surgery and the presence of metastasectomy for both PFS and OS were found to be independent prognostic factors. Moreover, a logistic regression analysis indicated that PLR and tumor localization were found to be an independent factors for predicting response to systemic treatment (P P = .023 respectively). Our results showed that pretreatment PLR was readily feasible and simple biomarker predicting response to treatment and survival, in addition it was significantly associated with tumor localization.Publication Metadata only Role of Urotensin-2 in 5-Fluorouracil-Related Arterial Vasoconstriction in Cancer Patients(2018-01-01) Seker, MESUT; ISEN, Hayati C.; Cevirme, NİDAL; Aydin, Sinem; Bilici, Ahmet; COBAN, EZGİ; Bulut, HURİ; YASIN, Ayse I.; Demir, TARIK; Aliyev, ALTAY; Kocyigit, ABDÜRRAHİM; Turk, Haci M.; ŞEKER, MESUT; ÇEVİRME, NİDAL; BULUT, HURI; ÇOBAN, EZGİ; DEMİR, TARıK; ALİYEV, ALTAY; KOÇYİĞİT, ABDÜRRAHİM; TÜRK, HACI MEHMETBackground: The aim of this study was to identify the possible relationship of 5-fluorouracil (5-FU)-related arterial vasoconstriction with urotensin-2 (UT-2), which has a high potential as an endogenic vasoconstrictor. Methods: We assigned the patients to 1 of 3 groups. Patients in group 1 received a bolus of 5-FU, those in group 2 a continuous infusion (CI) of 5-FU, and those in group 3 no 5-FU, which was also a control group. Pre- and post-treatment UT-2 levels and brachial arterial diameters were measured and recorded in all patients. Results: 132 patients were included in the study. Pre-and post-treatment brachial artery diameters were similar in all groups: in group 1 (3.28 +/- 0.52 vs. 3.25 +/- 0.44 mm, p = 0.740), in group 2 (3.57 +/- 0.47 vs. 3.46 +/- 0.45 mm, p = 0.441) and in the control group (3.51 +/- 0.52 vs. 3.25 +/- 0.44 mm, p = 0.818). Pre-and post-treatment UT-2 levels were significantly different in each group: in group 1 (39.5 +/- 30.9 vs. 56.7 +/- 27.1 ng/ml, p = 0.0001), in group 2 (37.7 +/- 33.7 vs. 62.5 +/- 37.7 ng/ml, p = 0.0001) and in the control group (52.9 +/- 40.2 vs. 60.8 +/- 40.7 ng/ml, p = 0.006). Conclusion: Our findings suggest that UT-2 has a high potential as a vasoconstrictor agent in our bodies and its level increases through a bolus or CI 5-FU. Increased UT-2 levels are likely to play a role in 5-FU-related cardiac toxicity pathogenesis. (c) 2018 S. Karger GmbH, FreiburgPublication Open Access Primitive Neuroectodermal Tumor of the Testis(2021-11-01T00:00:00Z) DEMİR, Tarık; ALİYEV, Altay; ŞEKER, Mesut; ERSÖZ, CEVPER; ÇOBAN, GANİME; TÜRK, HACI MEHMET; DEMİR, TARıK; ALİYEV, ALTAY; ŞEKER, MESUT; ERSÖZ, CEVPER; ÇOBAN, GANİME; TÜRK, HACI MEHMETA 21-year male presenting with left testicular mass and retroperitoneal lymphadenopathy underwent radical orchiectomy; and his pathological examination showed a mixed germ cell tumor composed of primitive neuroectodermal tumor mixed with mature teratoma. Six cycles of IE (ifosfamide, etoposide) and VAC (vincristine, doxorubicin, cyclophosphamide) chemotherapy were given after sperm preservation. He then underwent retroperitoneal lymph node dissection (RPLND). No tumor was detected in the removed lymph nodes, and all lymph nodes were reported as showing reactive changes.