Person: BABACAN YILDIZ, GÜLSEN
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Publication Open Access Cardiac safety of donepezil in elderly patients with Alzheimer disease(2012-01-01T00:00:00Z) Isik, AT; Yildiz, GÜLSEN; Bozoglu, E; Yay, A; Aydemir, E; BABACAN YILDIZ, GÜLSENObjective Donepezil is a widely used cholinesterase inhibitor for the treatment of Alzheimer's disease (AD), however its cholinergic adverse side effects on the cardiovascular system are still unclear. In this study, we aimed to examine the adverse side effects caused by donepezil on cardiac rhythm and postural blood pressure changes in elderly patients with Alzheimer Disease. Methods The ECG parameters including heart rate, PR, QT, QTc interval and QRS duration and postural blood pressure changes were recorded at the baseline and at each donepezil dose level (5 and 10 mg/d). Patients Seventy-one consecutive patients who were referred by primary care centers to a Geriatric Clinic were enrolled and underwent comprehensive geriatric assessment. Results Fifty-two subjects completed the study. There were no significant changes relative to the baseline in any of the ECG parameters or arterial blood pressure at any of the investigated dosages of donepezil. Conclusion It was demonstrated that donepezil was not associated with increased negative chronotropic, arrhythmogenic or hypotensive effects for elderly patients with Alzheimer's disease.Publication Open Access Motor and Non-Motor Symptoms in Parkinson-s Disease: Effects on Quality of Life.(2017-06-01) GÖKÇAL, ELİF; GÜR, VE; SELVITOP, R; Babacan, Yildiz; ASIL, TALİP; GÖKÇAL, ELİF; BABACAN YILDIZ, GÜLSEN; ASİL, TALIPIntroduction: This study aimed to evaluate motor and non-motor symptoms in idiopathic Parkinson's disease (IPD) patients and to determine the self-reported influence of all existing symptoms on their quality of life (QoL). Methods: The sociodemographic and clinical characteristics, medical treatments, and Modified Hoehn and Yahr (mH&Y) scores of IPD patients without cognitive impairment were recorded. A survey questioning different motor and non-motor symptoms was administered to the patients. The patients were asked to rate their symptoms by number from the greatest influence to the least influence on their QoL. Subjects were divided into two groups: those suffering from IPD for ≤5 years (Group 1) and those suffering from IPD for >5 years (Group 2). These groups were compared in terms of sociodemographic and clinical characteristics, existing symptoms, and influences of these symptoms on their QoL. Results: There were 63 patients in Group 1 and 37 patients in Group 2. No statistically significant differences were detected between the groups with respect to sociodemographic characteristics or mH&Y scores. The most common motor symptoms in both of these groups were tremor and bradykinesia; meanwhile, the non-motor symptoms most frequently encountered in these groups were pain-cramps, constipation, and excessive daytime sleepiness (EDS). Again, while the symptoms that most greatly disturbed QoL in all patients were reported to be tremor and bradykinesia, the most disturbing non-motor symptom was frequent voiding/incontinence, which was a less common symptom. Pain-cramp, constipation, and EDS, which were the most frequent non-motor symptoms, were the symptoms that least disturbed QoL. Conclusion: It is widely accepted that motor symptoms determine QoL in IPD. However, non-motor symptoms are seen during all phases of the disease. The impact of non-motor symptoms on the QoL of IPD patients remains substantial. Therefore, in addition to the well-known motor symptoms, non-motor symptoms, which may be overlooked during physical examination yet may profoundly impact QoL, should be questioned and treated appropriately to improve QoL in PD patients as much as possible.Publication Metadata only A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction.(2017-04-01T00:00:00Z) Lopez, Ana; Lee, Suzee E.; Wojta, Kevin; Ramos, Eliana Marisa; Klein, Eric; Chen, Jason; Boxer, Adam L.; Gorno-Tempini, Maria Luisa; Geschwind, Daniel H.; Schlotawa, Lars; Ogryzko, Nikolay V.; Bigio, Eileen H.; Rogalski, Emily; Weintraub, Sandra; Mesulam, Marsel M.; Fleming, Angeleen; Coppola, Giovanni; Miller, Bruce L.; Rubinsztein, David C.; Agosta, Federica; Alberici, Antonella; Babacan-Yildiz, GÜLSEN; Bennett, David A.; Bilguvar, Kaya; Borroni, Barbara; Caglayan, Ahmet O.; Combarros, Onofre; Comi, Giancarlo; Cortés, Etty P.; Ferrer, Isidre; Genç, Şermin; Gunel, Murat; Gylys, Karen H.; Indakoetxea, Begoña; Karageorgiou, Clementine E.; Karydas, Anna; Kilic, Ulkan; De Munain, Adolfo Lopez; Magnani, Giuseppe; Mahley, Robert W.; Boneschi, Filippo Martinelli; Martinez, Jacqueline; Mazzeo, Salvatore; Moreno, Fermin; Padovani, Alessandro; Papatriantafyllou, John; Rogaeva, Ekaterina; Sanchez-Juan, Pascual; Santangelo, Roberto; Small, Gary W.; Tarawneh, Rawan; Tartaglia, Maria Carmela; Vonsattel, Jean Paul G.; Yener, Gorsev; BABACAN YILDIZ, GÜLSENPublication Open Access Investigation of the Effects of Biochemical Parameters on Alzheimer-s Disease.(2019-07-16) Toprak, A; Gokce, MUSTAFA; Bektay, MUHAMMED YUNUS; Selvitop, R; Yildiz, GB; GÖKÇE, MUSTAFA; BEKTAY, MUHAMMED YUNUS; TOPRAK, ALİ; BABACAN YILDIZ, GÜLSENPublication Open Access Relationship between electrodiagnostic severity and neuropathic pain assessed by the LANSS pain scale in carpal tunnel syndrome.(2013-01-01T00:00:00Z) KOLUKISA, MEHMET; Gürsoy, AZİZE ESRA; YıLDıZ, GB; KOCAMAN, G; CELEBI, A; KOÇER, A; GÜRSOY, AZIZE ESRA; KOLUKISA, MEHMET; BABACAN YILDIZ, GÜLSENObjective: The aim of the study was to investigate the relationship between the presence of neuropathic pain assessed by the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scale and electrophysiological findings in patients with carpal tunnel syndrome (CTS). Methods: We studied 124 hands with idiopathic CTS with pain complaints involving hand and wrist. All hands were assessed by the LANSS with which a score of 12 or more is defined as pain dominated by neuropathic mechanisms. These hands were assigned to minimal, mild, moderate, severe, or extreme severe groups according to the results of the median nerve conduction studies. Results: A LANSS score $ 12, suggestive of pain dominated by neuropathic mechanisms, was defined in 59 (47.6%) CTS hands. Pain intensity was significantly higher in CTS hands with a LANSS score $ 12 (P , 0.001). Among electrophysiological findings, compound muscle action potential amplitude was significantly lower in hands with a LANSS score $ 12 compared with hands with a LANSS score , 12 (P = 0.020). Severity of CTS was not significantly different between LANSS $ 12 and LANSS , 12 groups. Electrophysiological severity was significantly higher in CTS hands with evoked pain (P = 0.005) and allodynia (P , 0.001) in LANSS subscore analysis. Conclusion: We suggest that the presence of pain dominated by neuropathic mechanisms in CTS is not related to electrophysiological CTS severity. Neuropathic pain should be assessed carefully in patients with CTS, and an appropriate treatment plan should be chosen, taking into account the clinical and electrophysiological findings together with the true pain classification. Keywords: electrodiagnostic evaluation, carpal tunnel syndrome, LANSS, neuropathic painPublication Open Access Association between etiology and lesion site in ischemic brainstem infarcts: a retrospective observational study.(2018-03-13) BARAN, GÖZDE; GULTEKIN, TO; BARAN, O; DENIZ, C; KATAR, SELAHATTİN; Yildiz, GÜLSEN; ASIL, TALİP; BARAN, GÖZDE; DENİZ, ÇİĞDEM; KATAR, SELAHATTİN; BABACAN YILDIZ, GÜLSEN; ASİL, TALIPBackground and purpose: To assess the anatomical distribution of the ischemic strokes of the brainstem, the effect of anatomical distribution on clinical features and prognosis, and the association between etiology and anatomical involvement. Methods: A retrospective search of the patient database of our institution was performed for a total of 227 patients who were admitted to the Department of Neurology, Medical Faculty of Bezmialem Vakif University between January 2012 and September 2014. Patients with adequate diagnostic data and 3-month follow-up visit were included in the study. Results: Twenty-one (9%), 136 (60%), and 65 (29%) patients had an infarction only at the mesencephalon, pons, and medulla, respectively. However, a single patient (0.5%) had an infarction both at the mesencephalon and pons, 3 (1.5%) at the pons and medulla, and 1 (0.5%) at the mesencephalon, pons, and medulla. While anterior involvement was more common in the mesencephalon and pons, posterior and lateral involvement occurred more frequently in the medulla. Large arterial atherothrombosis was the predominant cause of the strokes in all anatomical sites, particularly in infarcts involving the pons. Cardioembolic events were more common in patients with mesencephalic infarcts. Also, ischemia due to dissection was more common in infarctions involving the medulla, especially the lateral medulla. In subjects with simultaneous infarcts at other sites in addition to the brainstem, there was a significantly higher co-occurrence of medullary infarcts with cerebellar infarcts, mesencephalic infarcts with posterior cerebral artery infarcts, and pons infarcts with anterior circulation and multiple infarcts. Conclusion: Determination of risk factors and infarct localization as well as prediction of etiological parameters may assist in improving survival rates and therapeutic approaches.Publication Open Access Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders.(2019-10-01T00:00:00Z) Ayer, AH; Wojta, K; Ramos, EM; Dokuru, D; Chen, JA; Karydas, AM; Papatriantafyllou, JD; Agiomyrgiannakis, D; Kamtsadeli, V; Tsinia, N; Sali, D; Gylys, KH; Agosta, F; Filippi, M; Small, GW; Bennett, DA; Gearing, M; Juncos, JL; Kramer, J; Lee, SE; Yokoyama, JS; Mendez, MF; Chui, H; Zarow, C; Ringman, JM; Kilic, U; Babacan-Yildiz, GÜLSEN; Levey, A; DeCarli, CS; Cotman, CW; Boxer, AL; Miller, BL; Coppola, G; BABACAN YILDIZ, GÜLSENPublication Metadata only Idiopathic spinal accessory nerve palsy: A case report and review of the literature.(2013-01-01T00:00:00Z) Gürsoy, AZİZE ESRA; BABACAN-YıLDıZ, G; KOLUKıSA, MEHMET; CELEBI, A; GÜRSOY, AZIZE ESRA; BABACAN YILDIZ, GÜLSEN; KOLUKISA, MEHMETPublication Metadata only Subacute Combined Degeneration of the Spinal Cord due to Different Etiologies and Improvement of MRI Findings.(2013-01-01T00:00:00Z) Gürsoy, AE; Kolukısa, M; Babacan-Yıldız, GÜLSEN; Celebi, A; BABACAN YILDIZ, GÜLSENPublication Open Access Altered gut microbiota in patients with idiopathic Parkinson’s disease: an age–sex matched case–control study(2023-01-01) Babacan Yildiz G.; Kayacan Z. C.; KARACAN İ.; SÜMBÜL B.; Elibol B.; Gelisin O.; Akgul O.; BABACAN YILDIZ, GÜLSEN; SÜMBÜL, BİLGE; GELİŞİN, ÖZLEMObjective: The investigations related to how gut microbiota changes the brain-gut axis in idiopathic Parkinson's disease (PD) attract growing interest. We aimed to determine whether gut microbiota is altered in PD patients and whether non-motor symptoms of PD and disease duration had any relation with alterations of microbiota profiles among patients. Methods: Microbial taxa in stool samples obtained from 84 subjects (42-PD patients and 42-healthy spouses) were analyzed using 16S rRNA amplicon-sequencing. Results: We observed a significant decrease of Firmicutes and a significant increase of Verrucomicrobiota at the phylum level. At the family level, Lactobacillaceae and Akkermansiaceae were significantly increased and Coriobacteriales Incertae Sedis were significantly decreased in the PD patients compared to their healthy spouses. Genus level comparison inferred significant increase in abundance only in Lactobacillus while the abundance of Lachnospiraceae ND3007 group, Tyzzerella, Fusicatenibacter, Eubacterium hallii group and Ruminococcus gauvreauii group were all decreased. We determined that the abundance of Prevotella genus decreased, but not significantly in PD patients. In addition, we found differences in microbiota composition between patients with and without non-motor symptoms. Conclusion: We observed differences in gut microbiota composition between PD patients and their healthy spouses. Our findings suggest that disease duration influenced microbiota composition, which in turn influenced development of non-motor symptoms in PD. This study is the first in terms of both gut microbiota research in Turkish PD patients and the probable effect of microbiota on non-motor symptoms of PD.