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GÜLER, ERAY METİN

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ERAY METİN
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Start date: 2020 × End date: 2024 × Author: BEKTAY, MUHAMMED YUNUS ×

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Now showing 1 - 3 of 3
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    Neurotrophic and antioxidant effect of rTMS in Alzheimer’xxs Disease
    (2020-07-15T00:00:00Z) VELİOĞLU, HALİL AZİZ; GÜLER, ERAY METİN; Oznur, Mutlu Burnaz; BEKTAY, MUHAMMED YUNUS; HANOĞLU, LÜTFÜ; GÜLER, ERAY METİN; BEKTAY, MUHAMMED YUNUS
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    Neurotrophic and antioxidant effect of rTMS in Alzheimer-s Disease.
    (2020-07-16T00:00:00Z) Mutlu-Burnaz, Ozlem; Velioğlu, Halil Aziz; Hanoglu, Lutfu; Bektay, Muhammed Yunus; GÜLER, ERAY METİN; BEKTAY, MUHAMMED YUNUS
    Aims: Repetitive Transcranial Magnetic Stimulation (rTMS) is a neuromodulation tool recently suggested for as a means of intervention in neurodegenerative diseases. Many studies have revealed via neuropsychological testing that rTMS promotes cognitive and behavioral improvements. However, the neurotrophic and antioxidative efficacy of rTMS has not been well investigated in neurodegenerative diseases. The brain-derived neurotrophic factor (BDNF) modulates neurotransmitters and plays an important role in the survival of neurons, growth of synapses and differentiation of new neurons arising from projector cells. Oxidative stress is one of the main factors that threaten neuronal survival. The purpose of this study was to investigate the effects of rTMS on neurotrophic and antioxidative factors in Alzheimer-s Disease (AD).Methods: 20 Hz rTMS was applied to the left lateral parietal cortex of 18 patients with AD (CDR≥1 age AVG and SD: 70.05±7.86) for ten days. Blood samples were collected before and 2 weeks after the rTMS sessions. BDNF levels were measured to detect neurotrophic changes in the stored samples. Oxidative stress index (OSI), total thiol, native thiol, and disulfide metabolite levels were measured to detect antioxidative changes.Results: BDNF (p<0.05), total thiol (p<0.002), and native thiol (p<0.0001) levels were increased, while OSI (p<0.001) and disulfide (p<0.001) levels decreased after rTMS. Additionally, there was a correlation between BDNF and total thiol (p<0.05)/native thiol levels (p<0.02).Conclusions: In metabolic reactions, thiol levels decrease in the oxidation process, while disulfide bonds increase. In conclusion, rTMS both increased neurotrophic activity and reduced oxidative stress.
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    Investigation of DNA damage, oxidative stress, and inflammation in synthetic cannabinoid users.
    (2020-06-08T00:00:00Z) Kocyigit, A; Guler, Eray Metin; Bektay, MUHAMMED YUNUS; Akyildiz, Ayşenur; Sisman, BH; Izzettin, Fikret Vehbi; GÜLER, ERAY METİN; BEKTAY, MUHAMMED YUNUS; GÜNAYDIN AKYILDIZ, AYŞENUR; İZZETTİN, FIKRET VEHBI; KOÇYİĞİT, ABDÜRRAHİM
    Background: The widespread use of synthetic cannabinoids (SCs) among youth has become an important public health problem. Several life-threatening side effects of SC have been reported, including cardiovascular, gastrointestinal, neurological, renal, metabolic, ophthalmologic, and pulmonary effects, besides skin toxicity and hepatotoxicity. Methods: Given that high levels of SC can lead to oxidative stress, DNA damage, and inflammation, it has been aimed in this study to investigate the effects of SC in aspects of primary DNA damage, plasma total oxidant status (TOS)/total antioxidant status (TAS), thiol–disulfide homeostasis, myeloperoxidase (MPO) level, and cytokine levels (interleukin 1 beta (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-α)) of 40 SC users (SCUs) in Turkey. Results: Mean plasma TOS levels were significantly higher in the SCUs group than in the healthy group (HG). Similarly, mononuclear leukocyte DNA damage, plasma TOS, MPO activity, disulfide, oxidative stress index levels, IL-1β, IL-6, and TNF-α levels were significantly higher in the SCU group than in the HG, whereas plasma TAS, total, and native thiol levels were significantly lower in the SCU group than in the HG. Conclusion: It is concluded that SC can cause increase in oxidative stress and in inflammatory processes in addition to its potential for DNA damage. Additional studies with larger sample sizes and longer durations should be held to understand more specific outcomes of SC use.