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GÜLER, ERAY METİN

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ERAY METİN
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GÜLER
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2020 - 202429
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Start date: 2020 × End date: 2024 ×

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Now showing 1 - 10 of 29
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    Toxicity of Sodium Fluoride in Adult Retinal Pigment Epithelial Cells Related to Transepithelial Resistance Mechanism
    (2020-03-17T00:00:00Z) Erkan, Muhammed Abdulkadir; UMURHAN AKKAN, JÜLİDE CANAN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; UMURHAN AKKAN, JÜLİDE CANAN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM
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    Circulating levels of cytokines are increased in restless legs syndrome.
    (2020-10-21T00:00:00Z) Uslu, FI; Koçyiğit, A; Demir, E; Güler, Eray Metin; USLU, FERDA; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM
    Background: Restless legs syndrome [RLS] is known as a disease of iron and dopaminergic dysregulation but inflammatory processes might also have a role in the pathogenesis. In this study, we compared the circulating levels of hsCRP, IL-1β, IL-6, and TNF-α in patients with primary restless legs syndrome [RLS] and healthy control subjects. Methods: We prospectively included 29 patients with primary RLS and 65 healthy controls [HC], all age-sex matched. The diagnosis of RLS was established using international guidelines. IRLSSG Severity Scale was used to evaluate the severity of RLS. Plasma levels of hsCRP, IL-1β, IL-6, and TNF-α were measured in all participants. Results: The mean age of patients was 37.8 ± 11.3 and 52% of RLS group were women. Serum IL-1β, IL-6, and TNF-α levels of the patient group were statistically significantly higher compared to HC [p < 0.001 for all variables]. Plasma levels of hsCRP did not differ between groups. There were 8 patients with mild RLS [28%], 13 patients with moderate RLS [45%], and 8 patients with severe RLS [28%]. Only IL-6 values were significantly different between the groups. In the severe group, the value of IL-6 was significantly higher than in the other groups [p: 0.03]. Conclusion: These results showing higher circulating levels of inflammatory cytokines in patients with RLS support the notion that inflammation may be involved in the pathogenesis of primary RLS. However, it is necessary to perform further studies to determine if this finding is a cause or an effect.
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    Investigation of Oxidative Stress and Inflammation in Restless Legs Syndrome
    (2020-03-17T00:00:00Z) Demir, Ervanur; USLU, FERDA; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; USLU, FERDA; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM
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    Timokinon-oksim’in Melanoma Üzerindeki in vitro Etkisinin Araştırılması
    (2020-09-19T00:00:00Z) GÜLER, ERAY METİN; Özdemir, Mücahit; YALÇIN, BAHATTİN; GÜLER, ERAY METİN
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    Temel Mitokondriyal Tıp
    (2020-01-01T00:00:00Z) GÜLER, ERAY METİN; GÜLER, ERAY METİN
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    Investigation of N-terminal Pro Brain Natriuretic Peptide, Oxidative Stress, and Thiol Disulfide Homeostasis in Vitiligo Patients
    (2020-03-17T00:00:00Z) Kutlu, Büşra; EMİROĞLU, NAZAN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; EMİROĞLU, NAZAN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM
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    Comparative Effects of Combustible Cigarette and IQOS on Experimental Rat Model
    (2020-03-17T00:00:00Z) Demir, Sena Nur; Ogun, Hamza; GÜLER, ERAY METİN; Bozali, Kubra; Kadı, Ömer Faruk; Yıldırım, Kadir Berat; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM
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    The Effect of Antiretroviral Therapy on IL-6, IL-1β, TNF-α, IFN-γ Levels and their Relationship with HIV-RNA and CD4+ T Cells in HIV Patients.
    (2020-07-12T00:00:00Z) Koc, MM; Kocyigit, A; Yabaci, A; Guler, Eray Metin; Okay, G; Akkoyunlu, Y; OKAY, GÜLAY; MERİÇ KOÇ, MELİHA; GÜLER, ERAY METİN; YABACI TAK, AYŞEGÜL; KOÇYİĞİT, ABDÜRRAHİM; AKKOYUNLU, YASEMİN
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    Rheum ribes L.’nin etanol ekstraktlarının malign melanomahücreleri üzerine anti-kanser etkinliği
    (2020-03-01T00:00:00Z) KİRMİT, ADNAN; TAKIM, KASIM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VİLDAN BETÜL; BULUT, HURİ; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM
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    Comparing healing effect against ulcerative colitis and toxicological effects of Rosmarinus officinalis: A comprehensive in vivo study of an edible plant in rats
    (2022-07-01T00:00:00Z) YILMAZ, ANIL; UÇKAYA, FATİH; BAYINDIR, NİHAN; GÜLER, ERAY METİN; TOPRAK, ALİ; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTI; UÇKAYA, FATİH; BAYINDIR, NİHAN; GÜLER, ERAY METİN; TOPRAK, ALİ; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTI
    Ulcerative colitis (UC) is a chronic and inflammatory disorder of the gastrointestinal (GI) tract. UC usually worsens the daily life of the patient and may sometimes become mortal. There is no known remedy discovered against UC, yet. Rosmarinus officinalis consists of many flavonoids, phenolics, and terpenoids possessing various biological activities such as anti-inflammatory. For this reason, in the present study, anti-ulcerative colitis effect of ROME (Rosmarinus officinalis methanol extract) was investigated comprehensively by histopathological studies, a number of in vivo anti-inflammatory activities and several in vivo antioxidant activities, in addition to in vitro antioxidant activities and biochemical analyses. In addition, the toxic effects of ROME were examined. The results showed that ROME provided a significant healing effect against ulcerative colitis in rats. Both in vitro and in vivo assay results correlated with histopathological examinations. ROME exhibited minimal toxic alterations. When the results of rosemary are compared with the results of sulfasalazine, it can be suggested that instead of synthetic drugs with side effects, natural sources can be used for the treatment of various diseases. Although some activities of rosemary have been investigated in vitro in the previous studies, this is the first study revealing anti-ulcerative colitis effect of rosemary through histopathological studies, in vivo and in vitro assays as well as biochemical analyses overall. Practical applications The results revealed and proved that ROME provided a significant healing effect against ulcerative colitis in rats. When the results of rosemary are compared with the results of sulfasalazine, a commercially available drug on the market, it can be suggested that instead of synthetic drugs with side effects, natural sources can be used for the treatment of various inflammatory diseases such as UC disease. In addition, ROME possesses limited toxic alterations, but not much more than the commercial drug. As a future perspective, lethal and therapeutic doses can be examined and determined. Thus, human studies can be started through this comprehensive in vivo study on rosemary which is commonly used as an edible plant and spice all over the world.