Person: DESTEK, SABAHATTİN
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Publication Metadata only Hereditary Thrombophilia Risk Factors In Patients With Venous Thromboembolism(2020-01-01T00:00:00Z) Destek, Sabahattin; Gül, Vahit Onur; DESTEK, SABAHATTİNVenous thromboembolic disease (VTD) is a serious cause of mortality and morbidity with an incidence of 0.1% per year. The etiology of VTD is multifactorial and associated with acquired and hereditary conditions. The aim of our study was to investigate the presence of rare genetic mutations in VTD patients and to evaluate their distribution according to thrombosis sites.The study group consisted of 107 patients who underwent genetic testing for thrombophilia due to VTD between 2015 and 2017. Patients with VTD who underwent thrombophilic genetic examination by polymerase chain reaction method were included in the study. Antithrombin III, protein C and protein S deficiency patients diagnosed with biochemical tests were excluded from the study. The demographic characteristics and clinical results of the patients were obtained from the hospital archive. The control group consisted of 112 healthy individuals randomly selected from the community. The patient group and the control group were compared.The mean age of the patients was 39.6 years. The female/male ratio was 1.7. Advanced age and female gender were statistically significantly more frequent in the patient group (In both, p=0.0001). Factor V G1691A and B-Fibrinogen-455 genetic defects were statistically significantly higher in the patient group (Respectively; p=0.008, p=0.049). The most frequent (54.2%) PAI-4G&5G heterozygous gene defect was found in the patients. Deep venous thrombosis was detected in 54.2%, intraabdominal VTD in 4.7%, pulmonary embolism in 27.1%, and cerebral venous thrombosis in 30.8% of the VTD patients.Thrombophilic genetic mutations are not uncommon in patients with VTD. Thrombophilic genetic mutations in VTD etiology and in selected patients should be investigated. In patients without known thrombophilia mutations, rare thrombophilic mutations should be examined.Publication Metadata only Clinical and Pathological Evaluation of Benign Skin Lesions(2019-12-01T00:00:00Z) Destek, Sabahattin; Gül, Vahit Onur; DESTEK, SABAHATTİNSkin lesions are commonly benign in nature. The present study aims to evaluate the prevalence and clinicopathological characteristics of a large series of benign skin lesions (BSLs) excised in our clinic. Patients with skin lesions who underwent total excisional biopsy at the general surgery clinic between 2012 and 2016 were reviewed. A total of 551 patients with BSLs were included in the study. Of these, 43.7% were females and 56.7% were males. The age range was between 2 and 98 years with a mean of 39.7 years. The most commonly occurring group of BSLs was of the appendageal tumors (33.3%), and this finding was statistically significant. The most common keratinocytic BSL (13.6%) was verruca vulgaris. In the present study, various types of BSLs and their occurrences were evaluated. Benign skin tumors can turn into malignant types. A biopsy should be performed to establish the exact diagnosis. We performed an excisional biopsy to confirm the diagnosis.Publication Metadata only Recent Clinical Techniques, Results, and Research in Wounds(2017-09-01T00:00:00Z) Gül, Vahit Onur; Destek, Sabahattin; Ahioğlu, Serkan; DESTEK, SABAHATTİNPilonidal sinus is a common disease of the sacrococcygeal area. Although many surgical treatment methods have been described, there is no ideal treatment, owing to the high recurrence rates, and available surgical techniques are still subject to debate. The existing treatment methods range from complete and large excision with or without wound closure to curettage of the sinus with a brush. Because of the high recurrence rates, pilonidal sinus can become a chronic and complicated disease, particularly when it is in the intergluteal area. Sometimes it may fistulize to the gluteal area, with secondary orifices opening to this region. In recent years, minimally invasive surgical techniques have become increasingly common in parallel with increasing experience and development of new instruments. When compared with large excisions, limited excision of the pilonidal sinus tract (fistula) may be a better treatment option regarding healing time and patient comfort. In this section, we explain why limited excision is a good treatment option not only in simple pilonidal sinus cases but also in complicated cases with recurrence and fistulization.Publication Metadata only Akut mezenterik iskemi hastalarında L-laktat, D-dimer, lökosit, CRP ve nötrofil/lenfosit oranının prediktif ve prognostik değeri(2019-12-01T00:00:00Z) Destek, Sabahattin; Yabacı, Ayşegül; Değer, Kamuran Cumhur; Gül, Vahit Onur; Abik, Yağmur Nur; DESTEK, SABAHATTİN; YABACI TAK, AYŞEGÜL; DEĞER, KAMURAN CUMHURAcute mesenteric ischemia (AMI) is a disease that causes an ischemia in the intestines due to the obstruction of the mesenteric vessels feeding the intestines, with a mortality rate reaching up to 80%. The overall incidence of AMI is 0.63 per 100,000 people. Early diagnosis and treatment are very important for survival. There is no ideal biomarker that can reflect different types and stages of AMI. This study investigated the predictive and prognostic value of L-lactate, D-dimer, leukocyte, C reactive protein (CRP) and neutrophil/lymphocyte ratio (NLR) in the preoperative period were investigated in patients operated for AMI.