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Now showing 1 - 10 of 19
  • Publication
    Mide Kanserleri
    (2019-05-01T00:00:00Z) Akçakaya, Adem; Destek, Sabahattin; AKÇAKAYA, ADEM; DESTEK, SABAHATTİN
    Mide kanseri tedavisin de etkin yöntem radikal cerrahidir. D2 lenf nodu diseksiyonu (LND) ile gastrektomi standart tedavidir. Erken evre mide kanserlerinde (Evre IA) endoskopik tedavi yapılabilir. Evre IB-II-IIIA mide kanserlerinde radikal cerrahi yapılır. R0 rezeksiyon sağlamak ana hedeftir. Evre IIIB-IV gibi lokal ileri mide kanserlerinde genişletilmiş rezeksiyonla beraber D2 LND yapılabilir. Bu durumda cerrahi palyatif kalabilmekte ve prognoz üstüne etkisi olmamaktadır. Bursektominin surviye katkısı net olarak gösterilmemiştir. Rutin LND-nin bir parçası olarak splenektomi büyük ölçüde terk edilmiştir. Minimal invaziv cerrahi için genel olarak kabul edilen endikasyon erken mide kanserleridir. Laparoskopik ve Robotik yöntemlerle mide kanserinin cerrahi tedavisi gün geçtikçe artmaktadır. Tümörün lokalizasyonu, yaygınlığı, merkez ve cerrahın tecrübesine göre tercih edilme oranı değişmektedir. Radikal cerrahiye rağmen, ileri evre mide kanseri için uzun dönem sonuçları tatmin edici değildir. Tanı amaçlı laparoskopi ameliyat öncesi akılda tutulmalıdır. Neoadjuvan tedavi özellikle ileri evre kanserlerde önerilmektedir. Adjuvan kemoradyoterapi cerrahinin tamamlayıcısı olarak yerini korumaktadır.
  • Publication
    A Rare Disease of the Digestive Tract: Esophageal Melanosis
    (2016-06-01T00:00:00Z) Destek, SABAHATTİN; Gul, Vahit Onur; Ahioglu, Serkan; Erbil, Yesim; DESTEK, SABAHATTİN
    Esophageal melanosis which is characterized by melanocytic proliferation in the squamous epithelium of the esophagus and melanin accumulatin of esophageal mucosa (EM) is a rare disease of the digestive system. Although esophageal melanosis is considered to be a benign disease, its etiology is not cleared and has been reported to be the precursor lesion of esophageal primary melanomas. In this report, we aimed to note esophageal melanosis in a 55-year-old female case who applied to our clinic with difficulty in swallowing, burning behind the breastbone in the stomach, heartburn, indigestion, and pain in the upper abdomen after endoscopic and pathologic evaluation. Complaints dropped with anti-acid therapy and case was followed by intermittent endoscopic procedures because of precursor melanocytic lesions.
  • Publication
    Effectiveness of conservative approach in right colon diverticulitis
    (2019-07-01T00:00:00Z) DESTEK, SABAHATTİN; Gul, Vahit Onur; DESTEK, SABAHATTİN
    BACKGROUND: Approximately 10%-25% of patients with colon diverticular disease experience colonic diverticulitis during their lives. Right-sided diverticulosis is a rare condition in Western countries, but it is common among Asian countries. The aim of this study was to evaluate the clinical and treatment outcomes in our patients with right colon diverticulitis.
  • Publication
    Diffuse idiopathic necrobiosis lipoidica: case report
    (2018-01-01T00:00:00Z) Destek, SABAHATTİN; Gul, Vahit Onur; Ahioglu, Serkan; DESTEK, SABAHATTİN
    Necrobiosis lipoidica is a granulomatous skin disease whose etiology and pathogenesis are not fully explained. The association of necrobiosis lipoidica with diabetes mellitus is frequently discussed and it is thought that microangiopathy plays an important role. Although there are many treatment options, there is no standard treatment model. In this study; a 43-year-old female patient with common skin lesions and punch biopsy and necrobiosis lipoidica diagnosis was presented. The patient was found to have concomitant diabetes mellitus with necrobiosis lipoidica. After treatment, diabetes mellitus clinic resolves but the necrobiosis lipoidica does not fully recover; Autoimmune hepatitis was detected and immunosuppressive treatment was given and the patient-s treatment was provided. In this case report, etiology and treatment of necrobiosis lipoidica have been discussed based on this case.
  • Publication
    The Use of Ligasure Vessel Sealing System in Axillary Dissection; Effect on Seroma Formation
    (2014-09-01T00:00:00Z) Tukenmez, M.; Agcaoglu, O.; Aksakal, N.; Destek, SABAHATTİN; Cabioglu, N.; Barbaros, U.; Erbil, Y.; Bozbora, A.; Dinccag, A.; Ozmen, V.; Muslumanoglu, M.; Igci, A.; DESTEK, SABAHATTİN
    Background: Seroma formation is the most frequent postoperative complication after axillary dissection for breast surgery with an incidence of 10 - 50 %. This prospective clinical randomized study was carried out to evaluate the Ligasure vessel sealing system and its effect on seroma formation and other complications for axillary dissection.
  • Publication
    S100A4 May Be a Good Prognostic Marker and a Therapeutic Target for Colon Cancer
    (2018-01-01T00:00:00Z) DESTEK, SABAHATTİN; Gul, Vahit Onur; DESTEK, SABAHATTİN
    Background. Globally, the colorectal cancers rank the third in terms of cancer incidence and rank the fourth in cancer-associated deaths. S100A4, an important member of the S100 protein family, serves to promote tumor progression and metastasis. By conducting this study, we aim to examine the role of S100A4 in the prognosis of colon cancer and to demonstrate its prognostic significance. Methods. Tissue samples of colon cancer from 148 patients who underwent colon resection due to colon cancer were analyzed by immunohistochemical staining to determine the protein expression levels of S100A4. The protein expression levels of S100A4 in tumor tissue werematched with the clinicopathologic factors including patient survival. Results. Cytoplasmic expression of S100A4 protein was demonstrated in the tumor tissue of 132 patients (89.2%) out of a total of 148 study patients. Statistically, the expression levels of the cytoplasmic S100A4 protein correlated significantly with the TNM stages and patient survival. The distribution of the S100A4 protein staining in the tumor tissue was associated with the age groups, tumor localization, TNMstaging, and patient survival with statistical significance. The levels of S100A4 protein expressionwere found to be an independent prognostic factor for TNM staging and poor survival. Conclusion. Expression of the S100A4 protein in colon cancers may be an indicator of tumor progression and lymph node metastasis and may be useful for predicting the overall survival of the patients with colon cancer. In patients with colon cancer, it may be used as an indicator of poor prognosis.
  • Publication
    Comparison of Lichtenstein Repair and Mesh Plug Repair Methods in The Treatment of Indirect Inguinal Hernia
    (2018-07-01T00:00:00Z) Destek, SABAHATTİN; Gul, Vahit Onur; DESTEK, SABAHATTİN
    Objective: The lifetime risk to develop an inguinal hernia is 27%-43% for men and 3%-6% for women. Methods of hernia repair currently involve prosthetic mesh applications. The aim of this study is to compare the Lichtenstein repair and Mesh-plug repair methods in the surgical treatment of indirect inguinal hernias and to identify which of these two techniques is superior regarding its conferred advantages.
  • Publication
    Diagnostic efficacy of serum procalcitonin, IL-6, IL-2, and D-dimer levels in an experimental acute appendicitis model
    (2019-07-01T00:00:00Z) DESTEK, SABAHATTİN; Gul, Vahit Onur; Mentes, Mustafa Oner; Cicek, Ali Fuat; DESTEK, SABAHATTİN
    Background/Aims: Acute appendicitis is the most frequent cause of acute abdomen emergency surgery. It continues to be a problem today due to delayed diagnosis and its high perforation rate. For this reason, diagnostic tests continue to be developed. In this experimental study, the diagnostic significance of blood procalcitonin (PCT), interleukin (IL)-6, IL-2, and D-dimer levels in an acute appendicitis model in rabbits was investigated.
  • Publication
    Analysis of Appendiceal Neoplasms on 3544 Appendectomy Specimens for Acute Appendicitis: Retrospective Cohort Study of a Single Institution
    BACKGROUND Appendiceal neoplasms are rare and generally determined in appendectomy specimens for acute appendicitis. Depending on a tumor's histopathology and size, appendectomy or right hemicolectomy are the surgical treatment options. Adenocarcinomas, mucinous neoplasms, goblet cell carcinoids and neuroendocrine tumors are the types of the primary appendiceal neoplasm histopathology. In this study, we aimed to determine the incidence of appendiceal neoplasms in an acute appendicitis cohort. Also, histopathological distributions, demographic data, preoperative radiological diagnosis, and intraoperative findings were revealed for analysis, retrospectively. MATERIAL AND METHODS Between October 2011 and September 2017, 3554 appendectomies were performed for acute appendicitis in Bezmialem University Hospital, Istanbul Turkey. The medical records of these consecutive 3554 patients were evaluated retrospectively. After the histopathological analysis of the appendectomy specimens, a total of 28 patients were detected as having appendiceal neoplasm including appendiceal adenocarcinoma, low grade mucinous neoplasia, and appendiceal neuroendocrine tumors. RESULTS Appendiceal neoplasms were determined in 28 out of 3554 acute appendicitis patients with an incidence of 0.78%. According to the histopathological types, 3 of the cases (10.7%) were appendiceal adenocarcinoma, 8 of the cases (28.5%) were low grade mucinous neoplasia, and 17 of the cases (60.8%) were neuroendocrine tumors. The overall incidence of the appendiceal neuroendocrine tumors was 0.48%. CONCLUSIONS The information obtained from our study suggests that pathological examination of the specimen may not be necessary if there is no doubt according to preoperative radiological diagnosis and/or intraoperative findings of the surgeon.
  • Publication
    Akut mezenterik iskemi hastalarında L-laktat, D-dimer, lökosit, CRP ve nötrofil/lenfosit oranının prediktif ve prognostik değeri
    (2019-12-01T00:00:00Z) Destek, Sabahattin; Yabacı, Ayşegül; Değer, Kamuran Cumhur; Gül, Vahit Onur; Abik, Yağmur Nur; DESTEK, SABAHATTİN; YABACI TAK, AYŞEGÜL; DEĞER, KAMURAN CUMHUR
    Acute mesenteric ischemia (AMI) is a disease that causes an ischemia in the intestines due to the obstruction of the mesenteric vessels feeding the intestines, with a mortality rate reaching up to 80%. The overall incidence of AMI is 0.63 per 100,000 people. Early diagnosis and treatment are very important for survival. There is no ideal biomarker that can reflect different types and stages of AMI. This study investigated the predictive and prognostic value of L-lactate, D-dimer, leukocyte, C reactive protein (CRP) and neutrophil/lymphocyte ratio (NLR) in the preoperative period were investigated in patients operated for AMI.