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DESTEK, SABAHATTİN

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SABAHATTİN

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DESTEK

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    Mide Kanserleri
    (2019-05-01T00:00:00Z) Akçakaya, Adem; Destek, Sabahattin; AKÇAKAYA, ADEM; DESTEK, SABAHATTİN
    Mide kanseri tedavisin de etkin yöntem radikal cerrahidir. D2 lenf nodu diseksiyonu (LND) ile gastrektomi standart tedavidir. Erken evre mide kanserlerinde (Evre IA) endoskopik tedavi yapılabilir. Evre IB-II-IIIA mide kanserlerinde radikal cerrahi yapılır. R0 rezeksiyon sağlamak ana hedeftir. Evre IIIB-IV gibi lokal ileri mide kanserlerinde genişletilmiş rezeksiyonla beraber D2 LND yapılabilir. Bu durumda cerrahi palyatif kalabilmekte ve prognoz üstüne etkisi olmamaktadır. Bursektominin surviye katkısı net olarak gösterilmemiştir. Rutin LND-nin bir parçası olarak splenektomi büyük ölçüde terk edilmiştir. Minimal invaziv cerrahi için genel olarak kabul edilen endikasyon erken mide kanserleridir. Laparoskopik ve Robotik yöntemlerle mide kanserinin cerrahi tedavisi gün geçtikçe artmaktadır. Tümörün lokalizasyonu, yaygınlığı, merkez ve cerrahın tecrübesine göre tercih edilme oranı değişmektedir. Radikal cerrahiye rağmen, ileri evre mide kanseri için uzun dönem sonuçları tatmin edici değildir. Tanı amaçlı laparoskopi ameliyat öncesi akılda tutulmalıdır. Neoadjuvan tedavi özellikle ileri evre kanserlerde önerilmektedir. Adjuvan kemoradyoterapi cerrahinin tamamlayıcısı olarak yerini korumaktadır.
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    A Rare Disease of the Digestive Tract: Esophageal Melanosis
    (2016-06-01T00:00:00Z) Destek, SABAHATTİN; Gul, Vahit Onur; Ahioglu, Serkan; Erbil, Yesim; DESTEK, SABAHATTİN
    Esophageal melanosis which is characterized by melanocytic proliferation in the squamous epithelium of the esophagus and melanin accumulatin of esophageal mucosa (EM) is a rare disease of the digestive system. Although esophageal melanosis is considered to be a benign disease, its etiology is not cleared and has been reported to be the precursor lesion of esophageal primary melanomas. In this report, we aimed to note esophageal melanosis in a 55-year-old female case who applied to our clinic with difficulty in swallowing, burning behind the breastbone in the stomach, heartburn, indigestion, and pain in the upper abdomen after endoscopic and pathologic evaluation. Complaints dropped with anti-acid therapy and case was followed by intermittent endoscopic procedures because of precursor melanocytic lesions.
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    Using pentraxin-3 for diagnosing acute appendicitis and predicting perforation: A prospective comparative methodological study.
    (2020-01-01T00:00:00Z) Gul, VO; Destek, SABAHATTİN; DESTEK, SABAHATTİN
    BACKGROUND: In this study, we aimed to investigate the diagnostic performance of pentraxin-3 for acute appendicitis, and the predictive performance for perforation in patients with acute appendicitis, compared with white blood cell count, high-sensitivity C-reactive protein and interleukin-6 (IL-6). METHODS: This study was a prospective methodological study, in which we studied the accuracies of the serum levels of pentraxin-3, white blood cell count, interleukin-6 and high-sensitivity C-reactive protein in estimating acute appendicitis, and in estimating perforation in patients with acute appendicitis. We designed the control group with the patients diagnosed inguinal hernia and admitted for elective surgery. Receiver operating characteristics analysis was used to compare the diagnostic accuracies and predictive performances. RESULTS: Receiver operating characteristics analysis revealed that the Pentraxin-3 level >3.67 ng/mL showed the sensitivity of 95.5% and specificity of 100.0% for diagnosing acute appendicitis, with an area under the curve of 0.993 (95% CI 0.967–1.000). Also, the Pentraxin-3 level >9.56 ng/mL showed the sensitivity of 92.9%, and the specificity of 87.1% for the prediction of the perforation, with an area under the curve of 0.820 (95% CI 0.736–0.886). CONCLUSION: The diagnostic performance of Pentraxin-3 for acute appendicitis and the predictive performance for perforation were higher than white blood cell count, high-sensitivity C-reactive protein and interleukin-6.
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    Effectiveness of conservative approach in right colon diverticulitis
    (2019-07-01T00:00:00Z) DESTEK, SABAHATTİN; Gul, Vahit Onur; DESTEK, SABAHATTİN
    BACKGROUND: Approximately 10%-25% of patients with colon diverticular disease experience colonic diverticulitis during their lives. Right-sided diverticulosis is a rare condition in Western countries, but it is common among Asian countries. The aim of this study was to evaluate the clinical and treatment outcomes in our patients with right colon diverticulitis.
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    Diffuse idiopathic necrobiosis lipoidica: case report
    (2018-01-01T00:00:00Z) Destek, SABAHATTİN; Gul, Vahit Onur; Ahioglu, Serkan; DESTEK, SABAHATTİN
    Necrobiosis lipoidica is a granulomatous skin disease whose etiology and pathogenesis are not fully explained. The association of necrobiosis lipoidica with diabetes mellitus is frequently discussed and it is thought that microangiopathy plays an important role. Although there are many treatment options, there is no standard treatment model. In this study; a 43-year-old female patient with common skin lesions and punch biopsy and necrobiosis lipoidica diagnosis was presented. The patient was found to have concomitant diabetes mellitus with necrobiosis lipoidica. After treatment, diabetes mellitus clinic resolves but the necrobiosis lipoidica does not fully recover; Autoimmune hepatitis was detected and immunosuppressive treatment was given and the patient-s treatment was provided. In this case report, etiology and treatment of necrobiosis lipoidica have been discussed based on this case.
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    The Use of Ligasure Vessel Sealing System in Axillary Dissection; Effect on Seroma Formation
    (2014-09-01T00:00:00Z) Tukenmez, M.; Agcaoglu, O.; Aksakal, N.; Destek, SABAHATTİN; Cabioglu, N.; Barbaros, U.; Erbil, Y.; Bozbora, A.; Dinccag, A.; Ozmen, V.; Muslumanoglu, M.; Igci, A.; DESTEK, SABAHATTİN
    Background: Seroma formation is the most frequent postoperative complication after axillary dissection for breast surgery with an incidence of 10 - 50 %. This prospective clinical randomized study was carried out to evaluate the Ligasure vessel sealing system and its effect on seroma formation and other complications for axillary dissection.
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    S100A4 May Be a Good Prognostic Marker and a Therapeutic Target for Colon Cancer
    (2018-01-01T00:00:00Z) DESTEK, SABAHATTİN; Gul, Vahit Onur; DESTEK, SABAHATTİN
    Background. Globally, the colorectal cancers rank the third in terms of cancer incidence and rank the fourth in cancer-associated deaths. S100A4, an important member of the S100 protein family, serves to promote tumor progression and metastasis. By conducting this study, we aim to examine the role of S100A4 in the prognosis of colon cancer and to demonstrate its prognostic significance. Methods. Tissue samples of colon cancer from 148 patients who underwent colon resection due to colon cancer were analyzed by immunohistochemical staining to determine the protein expression levels of S100A4. The protein expression levels of S100A4 in tumor tissue werematched with the clinicopathologic factors including patient survival. Results. Cytoplasmic expression of S100A4 protein was demonstrated in the tumor tissue of 132 patients (89.2%) out of a total of 148 study patients. Statistically, the expression levels of the cytoplasmic S100A4 protein correlated significantly with the TNM stages and patient survival. The distribution of the S100A4 protein staining in the tumor tissue was associated with the age groups, tumor localization, TNMstaging, and patient survival with statistical significance. The levels of S100A4 protein expressionwere found to be an independent prognostic factor for TNM staging and poor survival. Conclusion. Expression of the S100A4 protein in colon cancers may be an indicator of tumor progression and lymph node metastasis and may be useful for predicting the overall survival of the patients with colon cancer. In patients with colon cancer, it may be used as an indicator of poor prognosis.
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    Comparison of Lichtenstein Repair and Mesh Plug Repair Methods in The Treatment of Indirect Inguinal Hernia
    (2018-07-01T00:00:00Z) Destek, SABAHATTİN; Gul, Vahit Onur; DESTEK, SABAHATTİN
    Objective: The lifetime risk to develop an inguinal hernia is 27%-43% for men and 3%-6% for women. Methods of hernia repair currently involve prosthetic mesh applications. The aim of this study is to compare the Lichtenstein repair and Mesh-plug repair methods in the surgical treatment of indirect inguinal hernias and to identify which of these two techniques is superior regarding its conferred advantages.
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    Diagnostic efficacy of serum procalcitonin, IL-6, IL-2, and D-dimer levels in an experimental acute appendicitis model
    (2019-07-01T00:00:00Z) DESTEK, SABAHATTİN; Gul, Vahit Onur; Mentes, Mustafa Oner; Cicek, Ali Fuat; DESTEK, SABAHATTİN
    Background/Aims: Acute appendicitis is the most frequent cause of acute abdomen emergency surgery. It continues to be a problem today due to delayed diagnosis and its high perforation rate. For this reason, diagnostic tests continue to be developed. In this experimental study, the diagnostic significance of blood procalcitonin (PCT), interleukin (IL)-6, IL-2, and D-dimer levels in an acute appendicitis model in rabbits was investigated.
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    Sinusectomy and primary closure versus excision and primary closure in pilonidal sinus disease: a retrospective cohort study
    (2020-01-01T00:00:00Z) Erol, Arzu; Goncu, Beyza S.; Hazer, Baki; ROSBERG, DERYA BURCU HAZER; DESTEK, SABAHATTİN
    Background Various surgical procedures are available for the treatment of pilonidal sinus diseases (PSD), but the best surgical approach remains controversial. Minimally invasive surgical procedures are more popular than surgery. This study aimed to evaluate the efficacy of sinusectomy with primary closure (SPC) in comparison with excision and primary closure (EPC) in primary or recurrent cases. Materials and methods This single-center retrospective cohort study was conducted with two cohort groups in which 351 patients with PSD underwent either SPC or EPC. The two procedures were compared according to the presence of short-term complications and recurrence of PSD. Results Of the patients, 134 underwent EPC and 217 underwent SPC. The length of stay and the wound healing time were significantly longer in the EPC group than in the SPC group. The occurrence rates of wound site infection and abscess were significantly higher in the EPC group than in the SPC group; however, seroma was statistically significantly more common in the SPC group than in the EPC group. The recurrence rates were 18.7% and 5.5% in the EPC and SPC groups, respectively. Conclusion SPC is an efficient procedure for the treatment of patients with PSD showing simple and complicated disease patterns.