Person: DESTEK, SABAHATTİN
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- PublicationMetadata onlyHereditary Thrombophilia Risk Factors In Patients With Venous Thromboembolism(2020-01-01T00:00:00Z) Destek, Sabahattin; Gül, Vahit Onur; DESTEK, SABAHATTİNVenous thromboembolic disease (VTD) is a serious cause of mortality and morbidity with an incidence of 0.1% per year. The etiology of VTD is multifactorial and associated with acquired and hereditary conditions. The aim of our study was to investigate the presence of rare genetic mutations in VTD patients and to evaluate their distribution according to thrombosis sites.The study group consisted of 107 patients who underwent genetic testing for thrombophilia due to VTD between 2015 and 2017. Patients with VTD who underwent thrombophilic genetic examination by polymerase chain reaction method were included in the study. Antithrombin III, protein C and protein S deficiency patients diagnosed with biochemical tests were excluded from the study. The demographic characteristics and clinical results of the patients were obtained from the hospital archive. The control group consisted of 112 healthy individuals randomly selected from the community. The patient group and the control group were compared.The mean age of the patients was 39.6 years. The female/male ratio was 1.7. Advanced age and female gender were statistically significantly more frequent in the patient group (In both, p=0.0001). Factor V G1691A and B-Fibrinogen-455 genetic defects were statistically significantly higher in the patient group (Respectively; p=0.008, p=0.049). The most frequent (54.2%) PAI-4G&5G heterozygous gene defect was found in the patients. Deep venous thrombosis was detected in 54.2%, intraabdominal VTD in 4.7%, pulmonary embolism in 27.1%, and cerebral venous thrombosis in 30.8% of the VTD patients.Thrombophilic genetic mutations are not uncommon in patients with VTD. Thrombophilic genetic mutations in VTD etiology and in selected patients should be investigated. In patients without known thrombophilia mutations, rare thrombophilic mutations should be examined.
- PublicationMetadata onlyClinical and Pathological Evaluation of Benign Skin Lesions(2019-12-01T00:00:00Z) Destek, Sabahattin; Gül, Vahit Onur; DESTEK, SABAHATTİNSkin lesions are commonly benign in nature. The present study aims to evaluate the prevalence and clinicopathological characteristics of a large series of benign skin lesions (BSLs) excised in our clinic. Patients with skin lesions who underwent total excisional biopsy at the general surgery clinic between 2012 and 2016 were reviewed. A total of 551 patients with BSLs were included in the study. Of these, 43.7% were females and 56.7% were males. The age range was between 2 and 98 years with a mean of 39.7 years. The most commonly occurring group of BSLs was of the appendageal tumors (33.3%), and this finding was statistically significant. The most common keratinocytic BSL (13.6%) was verruca vulgaris. In the present study, various types of BSLs and their occurrences were evaluated. Benign skin tumors can turn into malignant types. A biopsy should be performed to establish the exact diagnosis. We performed an excisional biopsy to confirm the diagnosis.
- PublicationOpen AccessPituitary Adenoma and Hyperprolactinemia Accompanied by Idiopathic Granulomatous Mastitis.(2017-01-01T00:00:00Z) Destek, SABAHATTİN; GUL, VO; AHIOGLU, S; SERIN, KR; DESTEK, SABAHATTİN
- PublicationMetadata onlyFibroepitelyal Anal Polipler Ve Eşlik Eden Anal Hastalıklar(2019-10-01T00:00:00Z) Destek, Sabahattin; DESTEK, SABAHATTİN
- PublicationMetadata onlyAKUT APANDİSİT TANISINDA PENTRAXİN-3 VE DİĞER AKUT FAZ REAKTANLARININ DEĞERLENDİRİLMESİ(2019-10-29T00:00:00Z) Destek, Sabahattin; Yapalak, Yunus; DESTEK, SABAHATTİN; YAPALAK, YUNUSAMAÇ: Akut apandisit acil cerrahide en sık karşılaşılan akut batın tablosudur ve apandektomi acil cerrahi girişimleri arasında en fazla yapılan ameliyattır. Ancak geç tanı ve perforasyon oranı yüksekliği hala sorun olmayı sürdürmektedir. Bu sebeple akut apandisit tanısını koymaya ve desteklemeye yönelik testler geliştirilmeye devam etmektedir. Bu çalışmamızda serum lökosit, C-reaktif protein (CRP), prokalsitonin, fibrinojen ve pentraxin-3 düzeylerinin akut apandisitteki tanısal ve prognostik etkinliği araştırıldı. MATERYAL-METOD: Yetişkin hastalardan (18-84 yaş arası) oluşan kontrol (n=110) ve akut apandisit hasta grubu (n=77) oluşturuldu. Kontrol grubunda %69’u kadın, hasta grubunda %46.8’i kadındı. Hastaların demografik özellikleri, ameliyat öncesi serum lökosit, CRP, prokalsitonin, fibrinojen ve pentraxin-3 seviyeleri ile bunların ameliyat öncesi yapılan batın tomografisi (BT) skorlarıyla, Alvarado skorlarıyla, apandisitin histopatolojik evreleriyle olan ilişkisine bakıldı. BULGULAR: Ortalama yaş, hasta grubunda 36.1 ± 13.6, kontrol grubunda 47.7 ± 16.6 yıldı. BT’de hastaların %13’ünde (n=10) perfore apandisit saptandı. İstatiksel olarak BT skorlarıyla CRP (p=0.001), prokalsitonin (p=0.019), fibrinojen (p=0.025) arasında anlamlı korelasyon varken lökosit ve pentraksin-3 ile korelasyon saptanmadı. Alvarado skorları ile lökosit (p=0.001) ve prolaksitonin (p=0.037) arasında arasında anlamlı korelasyon saptanmışken; CRP, fibrinojen ve pentraksin-3 ile korelasyon bulunmadı. Histopatolojik incelemelerde hastaların %6.5’inde (n=5) perfore apandisit saptandı. Apendisitin histopatolojik evreleriyle CRP (p=0.0001), prokalsitonin (p=0.0001) ve fibrinojen (p=0.008) arasında anlamlı şekilde korelasyon varken lökosit ve pentraksin- 3 ile korelasyon saptanmadı. SONUÇ: Bu klinik çalışmamızda özellikle prokalsitonin düzeyleri akut apandisit tanısı ve hastalığın evresi ile ilgili olarak iyi bir gösterge olduğu bulundu. Diğer taraftan pentraksin-3’ün tanıda ve prognozun belirlenmesinde bir öneminin olmadığı belirlendi.Anahtar Kelimeler: Apandisit, akut faz reaktanı, pentraxin-3
- PublicationOpen AccessBrunner-s Gland Hyperplasias and Hamartomas in Association with Helicobacter pylori(2019-01-01T00:00:00Z) DESTEK, SABAHATTİN; Gul, Vahit Onur; DESTEK, SABAHATTİNBackground. The proliferative lesions of the Brunner-s glands (BGs) are hyperplasia and hamartomas, and they are usually asymptomatic and very rarely diagnosed. The aetiology of these lesions is not yet clear. The aim of this study is to evaluate the clinical presentations of patients with BG hyperplasia and hamartomas and to assess the pathological features of these lesions in association with Helicobacter pylori (H. pylori). Methods. Our retrospective study included patients who underwent upper gastrointestinal system endoscopy between 2010 and 2015. The hospital records of 18 patients diagnosed with hyperplasia or hamartoma of BG were reviewed for the clinical and pathological findings. Data from patients with BG lesion were compared with 37 patients who had nonspecific duodenitis as the control group. Results. Female/male ratio in our study sample was 1/1. The age range was between 16 and 85 years with a mean age of 48.61. BG hyperplasia and hamartomas were found in 72.22 and 27.78% of the patients, respectively. The rate of H. pylori in gastric mucosa was 43.2% in the control group and 66.7% in the BG lesion group. In the BG lesion group, the rate of H. pylori was higher. H. pylori was identified in 60% of BG hamartomas and in 69.2% of hyperplastic BGs. Conclusion. Our study demonstrated that H. pylori may play an important role in the development of BG hyperplasia and hamartomas in association with chronic gastritis and duodenitis. This is probably due to chronic irritation.
- PublicationMetadata onlyRecent Clinical Techniques, Results, and Research in Wounds(2017-09-01T00:00:00Z) Gül, Vahit Onur; Destek, Sabahattin; Ahioğlu, Serkan; DESTEK, SABAHATTİNPilonidal sinus is a common disease of the sacrococcygeal area. Although many surgical treatment methods have been described, there is no ideal treatment, owing to the high recurrence rates, and available surgical techniques are still subject to debate. The existing treatment methods range from complete and large excision with or without wound closure to curettage of the sinus with a brush. Because of the high recurrence rates, pilonidal sinus can become a chronic and complicated disease, particularly when it is in the intergluteal area. Sometimes it may fistulize to the gluteal area, with secondary orifices opening to this region. In recent years, minimally invasive surgical techniques have become increasingly common in parallel with increasing experience and development of new instruments. When compared with large excisions, limited excision of the pilonidal sinus tract (fistula) may be a better treatment option regarding healing time and patient comfort. In this section, we explain why limited excision is a good treatment option not only in simple pilonidal sinus cases but also in complicated cases with recurrence and fistulization.
- PublicationMetadata onlyMinimally Invasive Surgical Approach to Complicated Recurrent Pilonidal Sinus(2015-01-01T00:00:00Z) Gul, Vahit Onur; Destek, SABAHATTİN; Ozer, Serhat; Etkin, Ergin; Ahioglu, Serkan; Ince, Mehmet; Cimin, Vedat; Sen, Deniz; Erbil, Yesim; DESTEK, SABAHATTİNPilonidal sinus is considered as a simple and frequently occurring disease localized at the sacrococcygeal area. However, at the intergluteal region, it can often turn into a chronic and complicated disease. In some cases, it can fistulize up to the gluteal region and appear at the secondary orifices. Minimally invasive surgical techniques are becoming widespread in recent years due to the increased experience and development of new instruments. Limited excision of the pilonidal sinus tract can be a better treatment option compared with large excisions in terms of recovery time and patient-s comfort. This case study reports the singlephase surgical treatment of complicated and recurrent pilonidal sinus localized at the gluteal area, with minimal tissue loss and inflammation.
- PublicationMetadata onlyThe Use of Ligasure Vessel Sealing System in Axillary Dissection; Effect on Seroma Formation(2014-09-01T00:00:00Z) Tukenmez, M.; Agcaoglu, O.; Aksakal, N.; Destek, SABAHATTİN; Cabioglu, N.; Barbaros, U.; Erbil, Y.; Bozbora, A.; Dinccag, A.; Ozmen, V.; Muslumanoglu, M.; Igci, A.; DESTEK, SABAHATTİNBackground: Seroma formation is the most frequent postoperative complication after axillary dissection for breast surgery with an incidence of 10 - 50 %. This prospective clinical randomized study was carried out to evaluate the Ligasure vessel sealing system and its effect on seroma formation and other complications for axillary dissection.
- PublicationOpen AccessRare Type Cranial Postauricular Pilonidal Sinus: A Case Report and Brief Review of Literature.(2017-01-01T00:00:00Z) Destek, SABAHATTİN; GUL, VO; AHIOGLU, S; DESTEK, SABAHATTİNA pilonidal sinus is a chronic inflammatory process, the etiology of which is still not fully elucidated. It frequently presents at the sacrococcygeal region (typical) and rarely at extrasacrococcygeal (atypical) locations, including the interdigital, axillary, inguinal, and umbilical regions, as well as the neck, face, and scalp. A 46-year-old man presented with a thirty-year history of a slowly growing nodule on the postauricular area of the scalp. The lesion was excised and diagnosed as a pilonidal sinus based on the clinical and histological findings. The purpose of this review is to report the unusual occurrence of a pilonidal sinus on the scalp and to review the literature regarding this particular location of occurrence.
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