Person: SOMUNCU, SALİH
Loading...
Status
Kurumdan Ayrılmıştır
Email Address
Birth Date
Name
Job Title
First Name
SALİH
Last Name
SOMUNCU
Organizational Units
6 results
Search Results
Now showing 1 - 6 of 6
Publication Metadata only Caustic esophageal injury decreases the number of interstitial cells of Cajal in the rat esophagus(2010-08-01T00:00:00Z) Soyer, Tutku; Ayva, Sebnem; Somuncu, SALİH; Atasoy, Pinar; Kanmaz, Turan; Cakmak, Murat; SOMUNCU, SALİHAim: To evaluate the effect of caustic esophageal injury (CEI) on the number of interstitial cells of Cajal (ICC)Publication Open Access A Comprehensive Review: Molecular and Genetic Background of Indirect Inguinal Hernias(2021-04-01T00:00:00Z) SOMUNCU, SALİH; Somuncu, Ozge Sezin; SOMUNCU, SALİHBackground: The occurrence of indirect inguinal hernias (IIH) is 5 times more prevalent than that of direct inguinal hernias (IH) and it is 7 times more common in males, owing to the attendance of the processus vaginalis (PV) throughout testicular descent. Summary: In children, the immense mainstream of IH is indirect. The progress of IIH development in children is instigated with a patent PV, which is mostly treated by simple herniorrhaphy. Syndromes of the collagen, microfibril, elastin, and glycosaminoglycan constituents of the extracellular matrix may attend to the development of IH. Our recent research showed that the lack of epithelial-mesenchymal transition (EMT) in children contributes to the development of IIH, while the scenario is defined as the opposite in adults. However, there is still a lack of knowledge on all of the genetic and molecular causes of the disease. Key Messages: Here we aimed to review the published genetic background of IH, the deficiencies of connective tissue causing the disease, recently defined molecular pathways involved including EMT, and possible recurrence reasons. This comprehensive study can deliver an analytic outline aiding to define patients with IH combined with fundamental genetic diseases.Publication Metadata only SALBUTAMOL AMELIORATES THE PHENOTYPE OF THE SKIN INFLAMMATORY DISEASE PSORIASIS ACCORDING TO SKIN SPHEROID MODELS(2021-10-01T00:00:00Z) Somuncu, Ozge Sezin; Demiriz, Berke; Turkmen, Irem; SOMUNCU, SALİH; AKSOY, BERNA; SOMUNCU, SALİHPsoriasis is a multifactorial chronic inflammatory disorder resulting by the interplay of genetics, the immune system and the environment. It is characterized by the hyperproliferation of epithelial cells, generating red, itchy psoriatic plaques which have no cure but have great negative impact in patients- life. Although corticosteroids or vitamin D analogs might help recovery to some extent, there is yet no total cure for the disease. In this study, we sought to generate three-dimensional (3D) stress-related psoriatic skin spheroids with the screening of the potential efficacy of a beta(2)-adrenergic receptor agonist, salbutamol. 3D Culture spheroids with human dermal fibroblasts (HDF), human epithelial keratinocytes (HEK) and human monocytic cell line (THP-1) were generated as a representative model of skin and the protocol of stress-related modelling was conducted. The efficacy of the drug salbutamol was evaluated by the changes in mRNA and protein expression levels of selected genes, as well as by several metabolic assays. We developed a method for culturing spherical organoid models of psoriasis in vitro. We tested the potential theurapetic effects of salbutamol on psoriasis spheroids. Spheroids treated with salbutamol indicated the effictiveness of the treatment. 3D spheroid system was found partially efficient for mimicking the physiological features of psoriasis in vitro. This present work may be a starting point for future investigation as it is the first to generate a stress-related psoriatic model and first to try a beta(2) agonist as a potential treatment option. Considering the effects and suitability of topical application of salbutamol, its efficacy should not be underestimated and should be investigated further for translating this knowledge into clinics.Publication Metadata only Characterization and Differentiation of Stem Cells Isolated from Human Newborn Foreskin Tissue(2015-11-01T00:00:00Z) Somuncu, Ozge Sezin; Tasli, Pakize Neslihan; Sisli, Hatice Burcu; Somuncu, SALİH; Sahin, Fikrettin; SOMUNCU, SALİHCircumcision is described as a cultural, medical, and religious process which states surgical removal of the foreskin either partly or fully. Cells isolated from the circumcised tissues are referred as foreskin cells. They have been thought as feeder cell lines for embryonic stem cells. Their fibroblastic properties were also utilized for several experiments. The waste tissues that remain after the circumcision thought to have stem cell properties. Therefore, there have been very few attempts to expose their stem cell properties without turning them into induced pluripotent stem cells. Although stem cell isolation from prepuce and their mesenchymal multilineage differentiation potential have been presented many times in the literature, the current study explored hematopoietical phenotype of newborn foreskin stem cells for the first time. According to the results, human newborn foreskin stem cells (hnFSSCs) were identified by their capability to turn into all three germ layer cell types under in vitro conditions. In addition, these cells have exhibited a stable phenotype and have remained as a monolayer in vitro. hnFSSCs suggested to carry different treatment potentials for bone damages, cartilage problems, nerve damages, lesion formations, and other diseases that are derive from mesodermal, endodermal, and ectodermal origins. Owing to the location of the tissue in the body and differentiation capabilities of hnFSSCs, these cells can be considered as easily obtainable and utilizable even better than the other stem cell sources. In addition, hnFSSCs offers a great potential for tissue engineering approaches due to exhibiting embryonic stem cell-like characteristics, not having any ethical issues, and teratoma induction as in embryonic stem cell applications.Publication Metadata only A case of split notochord syndrome: Presenting with respiratory failure in the neonatal period(2016-05-01T00:00:00Z) Coskun, Yesim; Akman, Ipek; Demir, Mustafa Kemal; Yapicier, Ozlem; Somuncu, SALİH; SOMUNCU, SALİHSplit notochord syndrome (SNS) is a very rare congenital anomaly. This report describes a male newborn with a neuroenteric cyst in the posterior mediastinum and multiple vertebrae anomalies presenting with respiratory failure and pulmonary hypertension. This report also discusses the embryological development and the etiologic theories of SNS.Publication Metadata only Protective effect of selenium on intussusception-induced ischemia/reperfusion intestinal oxidative injury in rats(2010-06-01T00:00:00Z) Akman, Hulya; Somuncu, SALİH; Dikmen, Gunnur; Ayva, Sebnem; Soyer, Tutku; Dogan, Pakize; Cakmak, Murat; SOMUNCU, SALİHAim: To evaluate the protective effect of selenium on intestinal ischemia-reperfusion injury due to intussusception.