Person: GÖKMEN KARASU, AYŞE FİLİZ
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Publication Metadata only Relationship between fetal peak systolic velocity in Middle cerebral artery and umbilical blood gas values and hemoglobin levels in diabetic pregnant women(2018-07-01T00:00:00Z) KÜTÜK, MEHMET SERDAR; DOLANBAY, MEHMET; Karasu, AYŞE FİLİZ; ÖZGÜN, MAHMUT TUNCAY; KÜTÜK, MEHMET SERDAR; GÖKMEN KARASU, AYŞE FİLİZPurposeTo assess the relationship between peak systolic velocity in the middle cerebral artery (MCA-PSV) and fetal hypoxia in diabetic pregnant women requiring insulin therapy.Publication Metadata only Incidence and outcomes of eclampsia: a single-center 30-year study(2019-04-01T00:00:00Z) Uludag, Semih Zeki; Karasu, AYŞE FİLİZ; KÜTÜK, MEHMET SERDAR; TAKMAZ, TAHA; GÖKMEN KARASU, AYŞE FİLİZ; KÜTÜK, MEHMET SERDAR; TAKMAZ, TAHAObjective: We aimed to determine the incidence of eclampsia at Erciyes University Hospital which is a tertiary referral center situated at central Anatolia. Additionally, we investigated eclampsia-associated maternal and perinatal outcomes for the 30-year study period. Methods: A retrospective review was performed for all women who were diagnosed with eclampsia and admitted to the Erciyes University Medical School, Department of Obstetrics and Gynecology from January 1985 to December 2015. Improvement in management gained over time was determined by comparing the results of the years 2005-2015 with data which were already published from years 1985-1999 and 2000-2004. Results: Eclampsia prevalence was 289/46,928 (% 0.61). Maternal age at the time of diagnosis did not differ statistically; however, gestational age at diagnosis and birth weight decreased significantly throughout the years (p < 0.005). The perinatal mortality rate showed a slight decrease throughout the years (p = 0.238). Maternal mortality rate also decreased throughout the years; it was 1.7% in 2005-2009 and 0 % in 2010-2015 (p = 0.246). Conclusion: The prevalence of eclampsia cases has decreased over the years. Maternal mortality attributed to eclampsia has also declined. The early diagnosis and treatment of eclampsia have resulted in the increase of premature deliveries. The perinatal mortality rate showed a slight decrease throughout the years (p = 0.238); however, it is not at a desirable rate compared to developed countries.Publication Metadata only Amniotic fluid -sludge-; prevalence and clinical significance of it in asymptomatic patients at high risk for spontaneous preterm delivery(2018-01-01T00:00:00Z) Adanir, Ilknur; ÖZYÜNCÜ, ÖZGÜR; Karasu, AYŞE FİLİZ; Onderoglu, Lutfu S.; GÖKMEN KARASU, AYŞE FİLİZIntroduction: The aim of our study is to determine prevalence and clinical significance of the presence of amniotic fluid sludge among asymptomatic patients at high-risk for spontaneous preterm delivery, prospectively.Material and methods: In our study, 99 patients at high risk for spontaneous preterm delivery were evaluated for the presence of amniotic fluid sludge with transvaginal ultrasonography at 20-22, 26-28, and 32-34 gestational weeks, prospectively; between August 2009 and October 2010 in Hacettepe University Hospital. And, these patients were followed up for their delivery weeks and pregnancy outcomes. We defined the high-risk group as the patients possessing one or more of the followings; a history of spontaneous preterm delivery, recent urinary tract infections, polyhydramnios, uterine leiomyomas, mullerian duct anomalies, and history of cone biyopsy or LEEP. Patients with multiple gestations, placenta previa, fetal anomalies, or symptoms of preterm labor at first examination were excluded.We have obtained ethical board approval from Hacettepe University (16.07.2009-HEK/No:09-141-59).Results: The prevalence of amniotic fluid sludge in the study population was 19,6% (18/92). The rates of spontaneous preterm delivery at <37 weeks of gestation were 66,7% (12/18), within the patients with sludge and 27,0% (20/74) within the patients without sludge. Patients with sludge had a higher rate of spontaneous preterm delivery (p=0.002). A higher proportion of neonates born to patients with amniotic fluid sludge had a neonatal morbidity (50% (9/18) vs. 24,3% (18/74), p=0.044) and died in the perinatal period, (p=0,013) than those born to patients without sludge. When we combined sludge and cervical lenght (CL) (<25mm) and used it as a screening test to identify women at risk for preterm delivery; it catched more women with preterm delivery, (p=0.000). While sensitivity of sludge was 37,5%, and sensitivity of CL was 34%, sensitivity of sludge positive or CL25mm was 56% for preterm birth (PTB) in high-risk group.Conclusions: The prevalence of amniotic fluid sludge is 19,6% and sludge is an independent risk factor for spontaneous preterm delivery among asymptomatic patients at high-risk for spontaneous preterm delivery. PTB is by far the leading cause of infant mortality, and prevention of PTB has been an elusive goal. When sludge added to screening, we can catch more PTB.Publication Metadata only Sonographic depiction of fetal ureters(2016-01-01) Karasu, AYŞE FİLİZ; Yuksel, Atil; Kutuk, Mehmet Serdar; Ilhan, Gulsah Keskin; GÖKMEN KARASU, AYŞE FİLİZAims: Classic literature states that the fetal ureter should not be visible unless dilated. Our main objective was to produce an effective, reproducible method for fetal ureter depiction during an anatomic survey. Our secondary objectives were to record the frequency of visible ureters among normal fetuses and among fetuses with mild pyelectasis and also to determine the diameter of the sonographically demonstrated ureter.Publication Metadata only The predictive value of weight gain and waist circumference for gestational diabetes mellitus(2019-09-01T00:00:00Z) TAKMAZ, TAHA; Yalvac, Ethem Serdar; ÖZCAN, Pınar; Coban, Ulas; Karasu, AYŞE FİLİZ; Unsal, Mehmet; TAKMAZ, TAHA; ÖZCAN, PINAR; GÖKMEN KARASU, AYŞE FİLİZObjective: The first objective of this study was to investigate the relationship between gestational diabetes mellitus (GDM) and gestational weight gain (WG), waist circumference (WC), prepregnancy, and gestational body mass index (BMI). The second aim of our study was to assess the ability of WG, WC, prepregnancy, and gestational BMI with special reference to their cut-off points on predicting the risk of GDM in pregnant women in Turkey.Publication Open Access Utilization of Wilms- tumor 1 antigen in a panel for differential diagnosis of ovarian carcinomas(2016-03-01) Sen, Dilek Sakirahmet; Karasu, AYŞE FİLİZ; Gecer, Melin Ozgun; KARADAYI, Nimet; Yamuc, Elif Ablan; GÖKMEN KARASU, AYŞE FİLİZObjective: Ovarian metasteses are often mistaken for primary adenocarcinoma. Studies conducted in recent years have focused on a search for an immunohistochemical marker to aid the differential diagnosis primary and metastatic ovarian carcinoma. Our study objective was to study the usefulness of Wilms tumor 1 (WT 1) antigen in this context. Materials and methods: The study was conducted at the pathology clinic of Lütfi Kırdar Training and Research Hospital. Deparaffinated blocks of 40 epithelial ovarian tumors, 40 colon adenocarcinomas, and 35 cases of omentum metastases were studied. Cytokeratin 7 (CK 7), cytokeratin 20 (CK 20), and WT 1 were applied to all specimens. Results: All ovarian adenocarcinomas were stained with CK 7 (100%). Colorectal adenocarcinomas were stained positive with CK 20 in 87.5% of cases. Primary ovarian adenocarcinomas stained positive with WT 1 in 82.5% of the cases and none of the colorectal adenocarcinomas showed staining with WT 1 (0%). Conclusion: WT 1 can be used in conjuction with CK 7 in the differential diagnosis of ovarian carcinomas.Publication Metadata only What is your diagnosis?(2017-12-01T00:00:00Z) Adanir, Ilknur; Karasu, AYŞE FİLİZ; Dane, Banu; ADANIR, İLKNUR; GÖKMEN KARASU, AYŞE FİLİZPublication Metadata only Effects of fetal cardiac anomalies on ductus venosus and aortic isthmus doppler profiles(2016-02-01) ILHAN, Gulsah; Iyibozkurt, Ahmet Cem; Kalelioglu, Halil Ibrahim; Ibrahimoglu, Lemi; ZEBİTAY, Ali Galip; EKEN, Meryem Kurek; Karasu, AYŞE FİLİZ; GÖKMEN KARASU, AYŞE FİLİZTo demonstrate the blood flow profiles of fetuses with cardiac anomalies at the level of Ductus venosus (DV) and Aortic isthmus (AI) to evaluate the effects of fetal cardiac anomalies on these profiles, and how these profile changes contribute to cardiac anomaly screening studies as a marker.Publication Metadata only Preliminary evaluation of foetal liver volume by three-dimensional ultrasound in women with gestational diabetes mellitus(2018-01-01T00:00:00Z) Ilhan, Gulsah; Gultekin, Huseyin; Kubat, Ayca; Karasu, AYŞE FİLİZ; Gungor, Emre Sinan; Zebitay, Galip Ali; Atmaca, Fatma Ferda Verit; GÖKMEN KARASU, AYŞE FİLİZThe aim of the study was to assess the standard foetal biometric measurements and foetal liver volume (FLV) in pregnancies complicated by gestational diabetes mellitus (GDM) at the time of GDM screening and to compare the results with foetuses in normal pregnancies. Ninety-seven pregnant women with normal singleton uncomplicated pregnancies between 24 and 28 weeks of gestation were allocated into GDM (+) (n: 33) and GDM (-) (n: 64) groups based on their 75 g oral glucose tolerance test results. Foetal biometric measurements and FLV measurements of the groups were compared. Although there were no significant differences in the standard biometric measurements between the two groups, FLV was significantly higher in the women with GDM (p < .01). The ROC analysis implied that with a cut-off value of FLV of 32.72 cm(3) for GDM prediction, the sensitivity was 78.8% and specificity was 56.3%. We suggest that FLV measurements during the second-trimester ultrasound scanning may be a tool for the prediction of GDM in the obstetric population.Publication Metadata only Risk factors and microbiology of wound infections following cesarean delivery: Experience of a single institution(2016-09-01) ILHAN, Gulsah; ATMACA, Fatma Ferda Verit; KAYA, Abdurrahman; ERGIN, Ahmet Hasan; Karasu, AYŞE FİLİZ; TURFAN, Mehtap; GÖKMEN KARASU, AYŞE FİLİZAims: To determine the prevalence of wound infection following cesarean delivery, risk factors, common bacterial pathogens and their antibiotic sensitivity.