Person: GÖKMEN KARASU, AYŞE FİLİZ
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Publication Treatment of ovarian damage induced by chemotherapeutic drugs in female rats with G-CSF and platelet-rich plasma(PRP): an immunohistochemical study correlation with novel marker INSL-3(2024-01-01) ÇETİN Ç.; Okten S. B.; TOK O. E.; Ozcan P.; GÖKMEN KARASU A. F.; Tanoglu F. B.; Taha H. S.; ATEŞ S.; ÇETİN, ÇAĞLAR; ÖZCAN, PINAR; GÖKMEN KARASU, AYŞE FİLİZ; TANOĞLU, FATMA BAŞAK; ATEŞ, SEDAObjective: To assess the impacts of Platelet-Rich Plasma(PRP) and Granulocyte Colony-Stimulating Factor(G-CSF) on a rat model with induced ovarian follicular damage caused by cyclophosphamide(Cy). Materials and Methods: Forty-two Sprague–Dawley rats were randomly allocated into seven distinct groups as; Group 1(control): NaCl intraperitoneal (IP) injection was administered on days D1, D7, and D14. Group 2(Cy):Cy IP injection on D1 + NaCl IP injection on D7 and D14 were administered. Group 3(PRP): PRP IP injection on D1,D7 and D14 were administered. Group 4(Cy + PRP):Cy IP injection on D1 and PRP IP injection on D1, D7 and D14 were administered. Group 5(G-CSF): G-CSF IP injection on D1, D7 and D14 were administered. Group 6(Cy + G-CSF):Cy IP injection on D1+ G-CSF IP injection on D1, D7 and D14 were administered. Group 7(Cy + PRP + G-CSF):Cy IP injection on D1+ PRP IP injection on D1,D7 and D14+ G-CSF IP injection on D1,D7 and D14 were administered. Follicular number, histological scores of AMH and INSL3 stained follicles at different stages of follicular development, and serum Anti-Müllerian hormone(AMH) were evaluated. Results: The primary, secondary, and antral follicle intensity scores for AMH-positive staining were most prominent in Groups 3 and 5. There was no significant difference between groups 4, 6 and 7 compared to group 1 in terms of follicule counts and AMH staining. The intensity scores of AMH-positive staining follicles were notably reduced in group 2 compared to groups 4, 6, and 7, with a significant difference (p <.01). Among the groups, group 2 exhibited the least intense antral follicle staining for INSL3, displaying a significant difference(p <.01) compared to the remaining groups. Conclusions: Autologous PRP and G-CSF might protect ovarian function in the face of ovarian damage caused by Cy-induced effects.Publication Prevalance of Urinary Incontinence and Anal Incontinence: An Internet Based Cross-Sectional Study of Female Turkish University Students(2023-10-01) GÖKMEN KARASU A. F.; Cetin C.; PASİN Ö.; Karacabay M.; Tanoglu F. B.; Ilhan G.; GÖKMEN KARASU, AYŞE FİLİZ; PASİN, ÖZGEPublication Administration of rectal cytotec versus rectal buscopan before hysteroscopy(2020-06-01T00:00:00Z) GÖKMEN KARASU, AYŞE FİLİZ; AYDIN, SERDAR; ATEŞ, SEDA; TAKMAZ, TAHA; Comba, Cihan; GÖKMEN KARASU, AYŞE FİLİZ; AYDIN, SERDAR; ATEŞ, SEDA; TAKMAZ, TAHAIntroduction:Our objective was to compare the effect of rectal misoprostol (Cytotec) versus rectal hyoscine-n-butyl bromide (Buscopan) on patients undergoing hysteroscopy. We hypothesised that HBB may have a role in cervical priming. Material and methods:This trial was conducted at Bezmialem Vakif University Hospital. Women of reproductive age between 18-50 years who were scheduled for operative hysteroscopy indicated by type 1 submucous myoma or endometrial polyps were recruited for the study. Ninety patients were divided randomly into three groups. Group 1 received placebo treatment. Group 2 received rectal 200 mcg misoprostol and Group 3 received rectal 20 mg hyoscine-n-butyl bromide two hours before the procedure. Procedures were performed using a bipolar 26 F (9 mm) continuous-flow rigid resectoscope with a 30 degrees lens. The outcome measures included cervical dilation width and time, ease of cervical dilation, procedure time and operative complications. Postoperative self-rated pain was assessed one hour after the procedure. Results:Thirteen patients (43. 3%) in the placebo treatment group, 11 patients (36.7%) in the misoprostol group and four patients (13.3%) in the hyoscine-n-butyl bromide group needed analgesics postoperatively (p = .02). The mean duration of cervical dilation time was longest in Group 1 and shortest in Group 3, however this difference did not reach statistical significance (p=.11). There was no difference with regard to other studied parameters. Summary:HBB reduced the need for pain medication compared to placebo. Larger studies are needed to further investigate the role of HBB in facilitating pre-operative cervical priming.Publication Relationship between fetal peak systolic velocity in Middle cerebral artery and umbilical blood gas values and hemoglobin levels in diabetic pregnant women(2018-07-01T00:00:00Z) KÜTÜK, MEHMET SERDAR; DOLANBAY, MEHMET; Karasu, AYŞE FİLİZ; ÖZGÜN, MAHMUT TUNCAY; KÜTÜK, MEHMET SERDAR; GÖKMEN KARASU, AYŞE FİLİZPurposeTo assess the relationship between peak systolic velocity in the middle cerebral artery (MCA-PSV) and fetal hypoxia in diabetic pregnant women requiring insulin therapy.Publication Malignant Brenner Tumor Of The Ovary Invading The Sigmoid Colon(2016-09-01T00:00:00Z) GÖKMEN KARASU, AYŞE FİLİZ; KIRAN, Gürkan; SÖNMEZ, FATMA CAVİDE; KUNDUZ, ENVER; GÖKMEN KARASU, AYŞE FİLİZ; KIRAN, GÜRKAN; SÖNMEZ, FATMA CAVİDE; KUNDUZ, ENVERPublication A rat hysteropexy model for evaluating adhesion formation and comparison of two different structured meshes.(2017-11-01T00:00:00Z) Gokmen-Karasu, Ayse Filiz; Aydin, SERDAR; Sonmez, Fatma Cavide; Adanir, Ilknur; Ilhan, Gulsah; Ates, Seda; GÖKMEN KARASU, AYŞE FİLİZ; AYDIN, SERDAR; ATEŞ, SEDAIntroduction and hypothesis Peritonization of mesh during sacrohysteropexy is generally advocated to prevent adhesions to the viscera; however, randomized clinical trials are lacking, and peritonization may not be completely possible in a laparoscopic hysteropexy procedure. Our main objective was to describe a basic experimental rat sacrohysteropexy model. We hypothesized that even when peritoneal closure was omitted, using composite mesh would result in less adhesions to the viscera.Publication Chronotype anc Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome(2021-01-01T00:00:00Z) GÖKMEN KARASU, AYŞE FİLİZ; Sahbaz, Cigdem Dilek; Dogu, Zeynep Filiz Eren; TAKMAZ, TAHA; ÇALI, HALİME; Tanoglu, Basak; GÖKMEN KARASU, AYŞE FİLİZ; ŞAHBAZ, ÇIĞDEM DILEK; TAKMAZ, TAHA; ÇALI, HALİMEAim: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder among women during the reproductive ages. The purpose of this study was to investigate the chronotype and sleep quality of PCOS patients.Publication Association between maternal vitamin D status in pregnant women and risk of gestational diabetes mellitus(2016-05-15T00:00:00Z) ATEŞ, SEDA; AYDIN, SERDAR; GÖKMEN KARASU, AYŞE FİLİZ; KILIÇ, GÖKHAN; KILIÇOĞLU DANE, PAKİZER BANU; ATEŞ, SEDA; AYDIN, SERDAR; GÖKMEN KARASU, AYŞE FİLİZ; KILIC, GÖKHAN; KILIÇOĞLU DANE, PAKİZER BANUPublication The role of clitoral topography in sexual arousal and orgasm: transperineal ultrasound study(2021-05-01T00:00:00Z) Aydin, Serdar; Bademler, Neslihan; Yardimci, Elif Asli Sarioglu; Arioglu, Cagri; GÖKMEN KARASU, AYŞE FİLİZ; GÖKMEN KARASU, AYŞE FİLİZIntroduction and hypothesis The clitoris has a critical pivotal role in female orgasm and arousal. The aim of this cross-sectional study was to evaluate topographic measurements of the clitoris, as well as to explore potential relationships between the clitoral complex and the orgasm domain of female sexual function, combining transperineal ultrasound with morphometric measurements. Methods In sexually active, heterosexual, premenopausal women, three-dimensional transperineal ultrasound imaging was used to measure the subpubic angle, the anterior triangle area (ATA) of the genital hiatus, the levator urethra gap, and the anteroposterior and transverse diameters of the genital hiatus. Mons pubis thickness, clitoris-urethra distance (CUD), clitoris-fourchette distance, and fourchette-perineal body distance were measured using a caliper. Comparison of measurements and correlation with orgasm score were performed. Results Among the 108 sexually active women, 30 (27.7 %) reported a low orgasm domain score. There were statistically significant differences between the low orgasm group and the control group in the ATA (4.05 vs 3.64 cm(2) respectively; p = 0.03), CUD (21 mm; p = 0.04 vs 16.1 mm; p = 0.04), and volume of the glans clitoris (947.7 mm(3) vs 1081 mm(3); p = 0.02). There was a moderate and inverse correlation between clitoris-urethra distance and orgasm (r = -0.53, p < 0.001), and arousal (r = -0.42 p < 0.001). Broader ATA (OR = 0.47; 95 % CI = 0.23-0.99; p = 0.04) and longer CUD (OR = 0.57; 95 % CI = 0.44-0.73; p < 0.001) were identified as the only independent predictors of orgasm problems. Conclusions Longer glans clitoris-urethra distance and broad space for the deep structures of the clitoris is related to difficulty in reaching orgasm and arousal problems.Publication Intraoperative Complications and Conversion to Laparatomy in Gynecologic Robotic Surgery(2021-06-01T00:00:00Z) GÖKMEN KARASU, AYŞE FİLİZ; KIRAN, Gürkan; Sanlikan, Fatih; GÖKMEN KARASU, AYŞE FİLİZ; KIRAN, GÜRKANIntroduction In this study our objective was to document complications encountered during our initial experience with the robotic system and also state the cases in which conversion to laparotomy was necessary. Material and Methods This study is a retrospective analysis of robotically performed gynecological and gynecologic oncology procedures at a single center from July 2016 to July 2018. Patient demographics and preoperative indications were obtained from the electronic medical records. Results The patients had a mean age of 53.6 years (range, 25-84 years). The operative time ranged from 1 h and 50 min to 9 h (mean, 5 h and 2 min). Most of the complications were managed within minutes and with robotic assisted suturing when necessary. Five patients out of 83 patients needed a surgical conversion from robotic surgery. Conversion rate was 6.02%. Conclusion During the study period we were able to manage complications uneventfully without requiring conversion to laparotomy most of the time. Vascular complications encountered during robotic surgery can be managed without requiring conversion to laparatomy.