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ÖZDEMİR, RAMAZAN

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    Early Left Atrial Mechanics and Volume Abnormalities in Subjects with Prehypertension: A Real Time Three-Dimensional Echocardiography Study
    (2012-11-01T00:00:00Z) Acikgoz, Nusret; Akturk, Erdal; ERMİŞ, NECİP; Yagmur, Julide; Kurtoglu, Ertugrul; CANSEL, MEHMET; Eyupkoca, Ferhat; PEKDEMİR, HASAN; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZAN
    The aim of this study was to evaluate left atrial (LA) volume and mechanical functions by real time three-dimensional echocardiography (RT3DE) in prehypertensive subjects. The study included 54 (34 male and 20 female) prehypertensive subjects and 36 (14 male and 22 female) healthy control subjects. Transthoracic echocardiography and RT3DE were performed in all patients. Interventricular septum thickness and isovolumetric relaxation time were significantly higher in prehypertensives than in controls (10.7 +/- 0.7 vs. 10.1 +/- 0.8 P = 0.001 and 89.9 +/- 10 vs. 82.4 +/- 11 P = 0.002, respectively). LA maximum volume, volume before atrial contraction, total and active stroke volume, total and active emptying fractions, expansion index, and LA max volume index were significantly higher in prehypertensives when compared with controls (P < 0.0001 for all). However, the passive emptying fraction was significantly lower in prehypertensives than controls (45.7 +/- 5.6 vs. 48.6 +/- 4.1, P = 0.006), and the minimum LA volume between the two groups was similar. The main finding of this study was that although LA volume and LA active systolic functions were significantly increased in prehypertensive people, there was a reduction in passive LA systolic functions. These parameters may be important in showing hemodynamic and structural changes in cardiac tissue caused by prehypertension. (Echocardiography 2012;29:1211-1217)
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    Uric Acid Level and Its Association with Carotid Intima-Media Thickness in Patients with Cardiac Syndrome X
    (2012-01-01T00:00:00Z) Acikgoz, Nusret; ERMİŞ, NECİP; Yagmur, Julide; Muezzinoglu, Kubra; Karakus, Yasin; CANSEL, MEHMET; PEKDEMİR, HASAN; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZAN
    Objective: The aim of our study was to evaluate serum uric acid level and its relationship with carotid intima-media thickness (CIMT) in patients with cardiac syndrome X (CSX). Subjects and Methods: A total of 50 patients with CSX (28 females/22 males, 51.0 +/- 10.9 years) and 40 controls (27 females/13 males, 53.0 +/- 10.2 years) were included in the study. All subjects underwent a noninvasive stress test and conventional coronary angiography. Serum uric acid levels were measured and B mode ultrasonography was performed to assess CIMT in all subjects. Results: Serum uric acid levels were higher in patients with CSX than in the control subjects (5.1 +/- 1.8 vs. 3.9 +/- 1.3 mg/dl; p = 0.002). The CIMT was higher in patients with CSX than in the control subjects (0.75 +/- 0.18 vs. 0.63 +/- 0.09 mm; p < 0.001). A significant correlation was found between serum uric acid values and CIMT measurements in patients with CSX (r = 0.666, p < 0.001). Conclusions: Serum uric acid levels were higher in patients with CSX and elevated serum uric acid levels were associated with carotid atherosclerosis, thereby indicating that elevated serum uric acid levels might contribute to the development of subclinical atherosclerosis in CSX patients. Copyright (C) 2011 S. Karger AG, Basel
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    Assessment of myocardial changes in athletes with native T1 mapping and cardiac functional evaluation using 3 T MRI
    (2016-06-01T00:00:00Z) GÖRMELİ, CEMİLE AYŞE; Gormeli, Gokay; Yagmur, Julide; Ozdemir, Zeynep Maras; Kahraman, Aysegul Sagar; ÇOLAK, CEMİL; ÖZDEMİR, Ramazan; ÖZDEMİR, RAMAZAN
    Intensive physical exercise leads to increases in left ventricular muscle mass and wall thickness. Cardiac magnetic resonance imaging allows the assessment of functional and morphological changes in an athlete-s heart. In addition, a native T1 mapping technique has been suggested as a non-contrast method to detect myocardial fibrosis. The aim of this study was to show the correlation between athletes- cardiac modifications and myocardial fibrosis with a native T1 mapping technique. A total of 41 healthy non-athletic control subjects and 46 athletes underwent CMR imaging. After the functional and morphological assessments, native T1 mapping was performed in all subjects using 3.0 T magnetic resonance imaging. Most of the CMR findings were significantly higher in athletes who had a parts per thousand yen5 years of sports activity when compared with non-athletic controls and athletes who had < 5 years of sports activity. Significantly higher results were shown in native T1 values in athletes who had < 5 years of sports activity, but there were no significant differences in the left ventricular end-diastolic volume, left ventricular end-diastolic mass, or interventricular septal wall thickness between non-athletic controls and athletes who had < 5 years of sports activity. The native T1 mapping technique has the potential to discriminate myocardial fibrotic changes in athletes when compared to a normal myocardium. The T1 mapping method might be a feasible technique to evaluate athletes because it does not involve contrast, is non-invasive and allows for easy evaluation of myocardial remodeling.
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    Comparision of pain levels of transradial versus transfemoral coronary catheterization: a prospective and randomized study
    (2014-03-01T00:00:00Z) Acikgoz, Nusret; Akturk, Erdal; Kurtoglu, Ertugrul; ERMİŞ, NECİP; Yagmur, Julide; Altuntas, Mehmet Sait; PEKDEMİR, HASAN; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZAN
    Objective: The aim of the present study was to assess access site pain levels of patients undergoing coronary catheterization via transradial route.
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    PublicationOpen Access
    P Wave Duration/P Wave Voltage Ratio Plays a Promising Role in the Prediction of Atrial Fibrillation: A New Player in the Game
    (2021-05-01T00:00:00Z) KARAÇÖP, ERDEM; ENHOŞ, Asim; BAKHSALIYEV, NIJAD; ÖZDEMİR, Ramazan; KARAÇÖP, ERDEM; ENHOŞ, ASIM; BAKHSALIYEV, NIJAD; ÖZDEMİR, RAMAZAN
    Background. Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. Identification of patients at risk for developing AF and the opportunity for early targeted intervention might have a significant impact on morbidity and mortality. Prolonged P wave duration and decreased P wave voltage have been shown to be independent predictors of AF. The present study aimed to investigate the role of P wave duration/P wave voltage in predicting new-onset AF. Methods. We screened a total of 640 consecutive patients who admitted to cardiology outpatient clinic with a complaint of palpitation between 2012 and 2014. 24-h Holter monitoring, echocardiography, and electrocardiography (ECG) recordings were reviewed to identify new-onset AF. Patients were assigned into two groups based on presence (n = 150) and absence (n = 490) of new-onset AF. Previous ECGs with sinus rhythm were analyzed. P wave duration was measured in inferior leads, and P wave voltage was measured in lead one. P wave duration/P wave voltage was also calculated for each patient. Results. One hundred fifty subjects (23.4%) had new-onset AF among 640 patients. P wave duration (123.27 +/- 12.87 vs. 119.33 +/- 17.39 ms, p=0.024) and P wave duration/P wave voltage (1284.70 +/- 508.03 vs. 924.14 +/- 462.06 ms/mV, p<0.001) were higher, and P wave voltage (0.12 +/- 0.04 vs. 0.13 +/- 0.04 mV, p<0.001) was significantly lower in the new-onset AF group compared with non-AFs. P wave duration/P wave voltage, with a cut off of 854.5 ms/mV, had 83.3% sensitivity and 62.0% specificity in a receiver operating characteristic curve (AUC 0.728, 95% CI 0.687-0.769; p<0.001). Their negative and positive predictive values were 78.7% and 68.6%, respectively. In a univariate regression analysis, age, smoking, C-reactive protein, brain natriuretic peptide, left atrial diameter, left atrial volume index, P wave duration, P wave voltage, and P wave duration/P wave voltage were significantly associated with the development of new-onset AF. Moreover, smoking (OR 4.008, 95% CI 1.707-9.409; p=0.001), left atrial volume index (OR 7.108, 95% CI 4.400-11.483; p<0.001), and P wave duration/P wave voltage (OR 1.002, 95% CI 1.000-1.003; p=0.044) were found to be significant independent predictors of new-onset AF in a multivariate analysis, after adjusting for other risk parameters. Conclusion. The P wave duration/P wave voltage ratio is a practical, easy-to-use, cheap, and reliable electrocardiographic parameter, which can play a promising role for both in predicting and elucidating a mechanism of new-onset AF.
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    Comparison of atrial electromechanical coupling interval and P-wave dispersion in non-dipper versus dipper hypertensive subjects
    (2011-02-01T00:00:00Z) Acikgoz, Nusret; ERMİŞ, NECİP; Cuglan, Bilal; CANSEL, MEHMET; Yagmur, Julide; Tasolar, Hakan; Barutcu, Irfan; PEKDEMİR, HASAN; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZAN
    Background. The lack of nocturnal BP fall less than 10% of the daytime, called non-dipper hypertension, is associated with increased cardiovascular morbidity and mortality. The aim of our study was to investigate atrial conduction time in patients with non-dipper hypertension using electromechanical coupling interval and P-wave dispersion (PWD), measured with the surface electrocardiogram and tissue Doppler echocardiographic imaging (TDI). Methods. Age-and sex-matched 43 dipper hypertensive patients (19 male, 24 female, mean age: 53.9 +/- 10.5 years), 40 non-dipper patients (18 male, 22 female, mean age 54.3 +/- 9.6 years) and 46 healthy subjects (22 male, 24 female, mean age: 52.8 +/- 9.6 years) were included in the study. The difference between the maximum and minimum P-wave durations was calculated and defined as PWD. Atrial electromechanical coupling (PA), inter-atrial and intra-atrial electromechanical delays were measured with TDI. Results. PWD was significantly higher in patients with non-dippers compared with dippers (p < 0.02) and controls (p < 0.001). The inter-atrial conduction time was delayed in non-dippers compared with dippers (p < 0.01) and controls (p < 0.001). There was a positive correlation between left atrial (LA) diameter and inter-atrial conduction times (r = 0.46, p < 0.001). LA diameter was also correlated with PWD (r = 0.44, p < 0.001). Conclusion. The patients with non-dipper hypertension have higher P-wave duration, PWD and delayed inter-atrial electromechanical coupling intervals compared with those of dippers and controls. This indicates that these subjects may be more prone to atrial rhythm disturbances.
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    Left atrial volume and function in patients with Behcet-s disease assessed by real-time three-dimensional echocardiography
    (2012-08-01T00:00:00Z) Acikgoz, Nusret; Akturk, Erdal; Yagmur, Julide; Kurtoglu, Ertugrul; ERMİŞ, NECİP; ŞENER, SERPİL; Karakus, Yasin; Akturk, Semra; Karincaoglu, Yelda; PEKDEMİR, HASAN; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZAN
    Aims Behcet-s disease (BD), a multisystemic inflammatory disorder, has been associated with a number of cardiovascular dysfunctions, including endomyocardial fibrosis of the right heart, atrial fibrillation, ventricular arrhythmias and sudden cardiac death. The incidence and nature of cardiac involvement in BD are not yet clearly documented. Our aim was to evaluate left atrial (LA) volume and functions using real-time three-dimensional echocardiography (RT3DE) in Behcet-s patients without any cardiac symptom.
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    The evaluation of non-ischemic dilated cardiomyopathy with T1 mapping and ECV methods using 3T cardiac MRI
    (2017-02-01T00:00:00Z) GÖRMELİ, CEMİLE AYŞE; Ozdemir, Zeynep Maras; Kahraman, Aysegul Sagir; Yagmur, Julide; ÖZDEMİR, Ramazan; ÇOLAK, CEMİL; ÖZDEMİR, RAMAZAN
    The aim of this study was to examine the correlation between ventricular function and the extracellular volume fraction (ECV) in patients with non-ischemic dilated cardiomyopathy (NIDCM) using 3.0 T magnetic resonance imaging (MRI). We also hypothesized that native T1 and ECV values would be increased in patients with NIDCM, independent of the left ventricular ejection fraction (LVEF). The findings of our study could lead to further studies of the follow-up protocols.
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    Elevated Oxidative Stress Markers and its Relationship With Endothelial Dysfunction in Behcet Disease
    (2011-05-01T00:00:00Z) Acikgoz, Nusret; ERMİŞ, NECİP; Yagmur, Julide; CANSEL, MEHMET; Karincaoglu, Yelda; Atas, Halil; Cuglan, Bilal; Barutcu, Irfan; PEKDEMİR, HASAN; ÖZDEMİR, Ramazan; AÇIKGÖZ, NUSRET; ÖZDEMİR, RAMAZAN
    Behcet-s disease (BD) is a multisystemic disorder characterized by endothelial dysfunction. However, the relationship between oxidative stress and endothelial function has not been clearly shown. We investigated the relationship between oxidative stress markers and endothelial function in patients with BD. Patients with BD (n = 40) having active disease and sex-and age-matched 40 controls were included. Endothelial function was assessed by flow-mediated dilatation (FMD) technique. Serum gammaglutamyltransferase (GGT) and high-sensitive C-reactive protein levels (hsCRP) were measured in all participants. Brachial artery FMD was significantly lower in patients with BD than in controls. Gamma-glutamyltransferase and hsCRP levels were higher in patients with BD than in controls. Also, GGT and hsCRP levels were inversely correlated with endothelial function. Oxidative stress markers are elevated in patients with BD having active disease. This may be one of the reasons behind the vasculitis in active BD.
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    PublicationOpen Access
    THE IMPACT OF ATRIAL FLOW REGULATOR IMPLANTATION ON HEMODYNAMIC PARAMETERS IN PATIENTS WITH HEART FAILURE
    (2021-01-01T00:00:00Z) BAKHSALIYEV, NIJAD; ÖZDEMİR, Ramazan; BAKHSALIYEV, NIJAD; ÖZDEMİR, RAMAZAN
    Background Left atrial decompression has emerged a new option to treat patients with heart failure and dyspnea at rest or during exercise. Here we report the impact of atrial flow regulator (AFR) implantation on hemodynamic parameters in patients at our center with heart failure and with reduced (HFrEF) or with preserved left ventricular ejection fraction (HFpEF).