2019-06-01T00:00:00Z, Güneş Bayır, Ayşe, Güney, Merve, GÜNEŞ BAYIR, AYŞE

2018-08-01, GÜNES-BAYIR, Ayse, KOÇYİĞİT, ABDÜRRAHİM, GÜLER, ERAY METİN, GÜNEŞ BAYIR, AYŞE, KOÇYİĞİT, ABDÜRRAHİM, GÜLER, ERAY METİN

2015-01-01, KIZILTAN, HURİYE ŞENAY, BAYIR, Ayşe Güneş, Yucesan, GÜL, Eris, ALİ HİKMET, KARATOPRAK, CUMALİ, İDİN, Kadir, AYDIN, TEOMAN, AKÇAKAYA, ADEM, MAYADAĞLI, ALPASLAN, KIZILTAN, HURİYE ŞENAY, GÜNEŞ BAYIR, AYŞE, YÜCESAN, GÜL, ERİŞ, ALİ HİKMET, KARATOPRAK, CUMALİ, AYDIN, TEOMAN, AKÇAKAYA, ADEM, MAYADAĞLI, ALPASLAN

2017-03-01, KIZILTAN, HURİYE ŞENAY, GÜNEŞ BAYIR, AYŞE, ERİŞ, ALİ HİKMET, BAŞIBÜYÜK, MERYEM, MAYADAĞLI, ALPASLAN, AKÇAKAYA, ADEM, ÇAKIR, FATMA BETÜL, AYDIN, TEOMAN, GÜL, KÜRŞAT, KARABAL, ESRA, ŞİMŞEK, MUHARREM, KIZILTAN, HURİYE ŞENAY, GÜNEŞ BAYIR, AYŞE, ERİŞ, ALİ HİKMET, BAŞIBÜYÜK, MERYEM, MAYADAĞLI, ALPASLAN, AKÇAKAYA, ADEM, ÇAKIR, FATMA BETÜL, AYDIN, TEOMAN, GÜL, KÜRŞAT, KARABAL, ESRA

2015-08-01, GUNES-BAYIR, Ayse, Kiziltan, HURİYE ŞENAY, Guler, ERAY METİN, KARAKAS, Ersin, Kocyigit, ABDÜRRAHİM, GÜNEŞ BAYIR, AYŞE, KIZILTAN, HURİYE ŞENAY, GÜLER, ERAY METİN, KOÇYİĞİT, ABDÜRRAHİM

2018-02-01, KIRSEVER, ESRA, KIZILTAN, HURİYE ŞENAY, YILMAZ, RABİYE, GÜNEŞ BAYIR, AYŞE, BAŞIBÜYÜK, MERYEM, ÇAKIR, FATMA BETÜL, GÜL, KÜRŞAT, ŞİMŞEK, MUHARREM, KIZILTEPE, AYŞE, GÜMÜŞ, ASLI, KALAYCI, KÜBRA, AKÇAKAYA, ADEM, MAYADAĞLI, ALPASLAN, AYDOĞDU, İBRAHİM, ALTINOK SÜT, PELİN, AYDIN, TEOMAN, KIZILTAN, HURİYE ŞENAY, ERİŞ, ALİ HİKMET, GÜNEŞ BAYIR, AYŞE, BAŞIBÜYÜK, MERYEM, ÇAKIR, FATMA BETÜL, GÜL, KÜRŞAT, GÜMÜŞ, ASLI, KALAYCI, KÜBRA, AKÇAKAYA, ADEM, MAYADAĞLI, ALPASLAN, AYDOĞDU, İBRAHİM, ALTINOK SÜT, PELİN, AYDIN, TEOMAN

2018-11-01, Günes-Bayir, AYŞE, Kocyigit, ABDÜRRAHİM, Güler, ERAY METİN, Bilgin, MEHMET GÜLTEKİN, Ergün, İLYAS SAMET, DADAK, A, GÜNEŞ BAYIR, AYŞE, KOÇYİĞİT, ABDÜRRAHİM, GÜLER, ERAY METİN, BİLGİN, MEHMET GÜLTEKİN, ERGÜN, İLYAS SAMET

2014-06-01, KIZILTAN, HURİYE ŞENAY, ERİŞ, ALİ HİKMET, MAYADAĞLI, ALPASLAN, GÜNEŞ BAYIR, AYŞE, YAGCI, B, TAŞPINAR, ÖZGÜR, AYDIN, TEOMAN, TRABZON, M, KIZILTAN, HURİYE ŞENAY, ERİŞ, ALİ HİKMET, MAYADAĞLI, ALPASLAN, GÜNEŞ BAYIR, AYŞE, AYDIN, TEOMAN

2013-05-24T00:00:00Z, GRAFL, Beatrice, LIEBHART, Dieter, Guenes, AYŞE, WERNSDORF, Patricia, AIGNER, Franz, BACHMEIER, Josef, HESS, Michael, GÜNEŞ BAYIR, AYŞE

In the present study day-old specific-pathogen-free (SPF) and commercial broilers with maternally derived fowl adenovirus serotype 1 (FAdV-1) antibodies were orally infected with a European -pathogenic- FAdV-1, isolated from broilers showing signs of gizzard erosion. During the experiment, broilers were observed and weighed daily up to 17 days post infection (dpi). Clinically, both infected groups showed significant decrease of weight compared to respective negative control groups. Birds were examined by necropsy at 3, 7, 10, 14 and 17 dpi. Pathological changes in the gizzards were noticed in both experimentally infected groups from 7 dpi onwards. Macroscopically, erosion of the koilin layer and inflammation or ulceration of the gizzard mucosa were observed. Histologically, presence of FAdV-1 in intranuclear inclusion bodies of degenerated glandular epithelial cells was demonstrated by in-situ hybridization and inflammatory cell infiltration of the lamina propria, submucosa and muscle layer was detected. Tissue samples were investigated by a recently developed real-time PCR and the viral DNA load was calculated from gizzard, liver, spleen and cloacal swabs with the highest amounts of FAdV-1 DNA found in the gizzard. For the first time, successful reproduction of clinical signs in broilers as well as pathological lesions in the gizzard were achieved with a European FAdV-1 isolate displaying some genetic differences to so far reported virulent FAdV-1 from Japan. Furthermore, highest viral load in gizzards could be linked with macroscopical and histological lesions. Therefore, the conducted analyses provide important insights into the pathogenesis of adenoviral gizzard erosion.

2010-12-01T00:00:00Z, MAREK, Ana, Guenes, AYŞE, SCHULZ, Evelyn, HESS, Michael, GÜNEŞ BAYIR, AYŞE

A total of 44 fowl adenovirus (FAdV) samples from 6 European countries, Pakistan, India, Kuwait, Mexico, Peru and Ecuador were used in this study and the phylogenetic analyses based on the loop 1 (L1) region of hexon gene were performed. For comparison, available hexon sequences of representatives of different FAdV species were also used. At least 12 genotypes within the five FAdV species (A-E) were revealed and the existence of these genotypes was supported by high bootstrap values. Furthermore, three primer pairs binding to the conserved pedestal regions (HexL1s/HexL1as and HexA/HexB) and pedestal (P1) region and loop 2 (L2) region (HexF1/HexR1) of the FAdV hexon gene were used for high-resolution melting (HRM)-curve analysis and results were compared with those of phylogenetic analyses. HRM-curve analysis based on the HexL1s/HexL1as region grouped all tested field isolates and reference strains into 22 subgroups, consistently with phylogenetic analysis. This method is a rapid and cost-effective alternative to existing serotype identification methods and offers a possibility to classify FAdV isolates more precisely. However, it has limitations such as need for extensive interpretation of results and potential for indeterminate results. Gaining of hexon sequences of further field isolates offers the potential for novel and additional information in analysis of the molecular epidemiology of FAdV. (C) 2010 Elsevier B.V. All rights reserved.