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ŞAHBAZ, ÇIĞDEM DILEK

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ÇIĞDEM DILEK
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ŞAHBAZ
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2018 - 20206
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Author: KIRPINAR, İSMET ×

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Now showing 1 - 6 of 6
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    Is there an association between theory of mind ability and biological rhythm disturbances in individuals with schizophrenia?
    (2018-03-01T00:00:00Z) Sahbaz, C.; Kurtulmus, A.; Kirpinar, I.; ŞAHBAZ, ÇIĞDEM DILEK; KIRPINAR, İSMET
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    A role of T cell subsets in the immun dysfunction of schizophrenia
    (2018-03-01T00:00:00Z) Sahbaz, C.; Zibandeh, N.; Kurtulmus, A.; Kirpinar, I.; Sahin, F.; Akkoc, T.; ŞAHBAZ, ÇIĞDEM DILEK; KIRPINAR, İSMET
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    Reduced regulatory T cells with increased proinflammatory response in patients with schizophrenia
    (2020-06-01T00:00:00Z) Sahbaz, Cigdem; Zibandey, Noushin; KURTULMUŞ, AYŞE; Duran, Yazgul; Gokalp, Muazzez; KIRPINAR, İSMET; ŞAHİN, FİKRETTİN; Guloksuz, Sinan; AKKOÇ, TUNÇ; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞE; KIRPINAR, İSMET
    Aim To investigate whether circulating T cells including regulatory T cells (Treg) and derived cytokines contribute to the immune imbalance observed in schizophrenia. Methods Forty patients with schizophrenia and 40 age, sex, body mass index, education, and smoking status-matched healthy controls (HC) are included in the study. We stained cells with anti-CD14, anti-CD3, anti-CD4, anti-CD8, anti-CD19, anti-CD20, and anti-CD16/56. Peripheral blood mononuclear cells (PBMCs) were isolated and stained with the human FoxP3 kit containing anti-CD4/anti-CD25 and intracellular anti-Foxp3. PBMCs were cultured for 72 h and stimulated with anti-CD3/anti-CD28. Cytokines (IL-2, IL-4, IL-6, IL-10, IFN-gamma, TNF-alpha, and IL-17A) were measured from the culture supernatant and plasma using the Th1/Th2/Th17 cytokine bead array kit. Results In comparison with HC, Treg percentages in schizophrenia were higher (1.17 +/- 0.63 vs 0.81 +/- 0.53, P = 0.005) in unstimulated but lower in the stimulated condition (0.73 +/- 0.69 vs 0.97 +/- 0.55, P = 0.011). Activated T cell percentages were higher in schizophrenia than HC in unstimulated (2.22 +/- 0.78 vs 1.64 +/- 0.89, P = 0.001) and stimulated (2.25 +/- 1.01 vs 1.72 +/- 1.00, P = 0.010) conditions. The culture supernatant levels of IL-6 (7505.17 +/- 5170.07 vs 1787.81 +/- 1363.32, P < 0.001), IL-17A (191.73 +/- 212.49 vs 46.43 +/- 23.99, P < 0.001), TNF-alpha (1557 +/- 1059.69 vs 426.57 +/- 174.62, P = 0.023), and IFN-gamma (3204.13 +/- 1397.06 vs 447.79 +/- 270.13, P < 0.001); and plasma levels of IL-6 (3.83 +/- 3.41vs 1.89 +/- 1.14, P = 0.003) and IL-17A (1.20 +/- 0.84 vs 0.83 +/- 0.53, P = 0.033) were higher in patients with schizophrenia than HC. Conclusion Our explorative study shows reduced level of Foxp3 expressing Treg in a stimulated condition with induced levels of proinflammatory cytokines in patients with schizophrenia.
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    Role of Lymphocyte Subsets and T-Cell Profiles in the Immune Dysfunction of Schizophrenia
    (2018-05-01) SAHBAZ, Cigdem; Zibandeyeh, Noushin; Kurtulmus, AYŞE; AVAROGLU, Gamze; Kirpinar, Ismet; Sahin, Fikrettin; AKKOÇ, TUNÇ; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞE; KIRPINAR, İSMET
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    Circadian preferences are associated with vegetative symptoms and comorbid medical diseases in patients with major depression
    (2019-09-03) Sahbaz, Çiğdem Dilek; Devetzioglou, Tougmpa; Ozcelik, Ayse Mine; KIRPINAR, İSMET; ŞAHBAZ, ÇIĞDEM DILEK; KIRPINAR, İSMET
    Circadian preferences may affect the severity and symptom structure of depression and could influence specific symptom clusters of depression. This study aims to examine the relationship between chronotypes and symptomatology in patients with major depression. One hundred and one drug-naive outpatients with major depression were evaluated through the use of the Hamilton Rating Scale for Depression (HRSD). The Morningness-Eveningness Questionnaire (MEQ) was used to the define chronotypes and the quality of subjective sleep was measured with Pittsburgh Sleep Quality Index (PSQI). The medical records of patients were evaluated retrospectively to determine the presence of another medical illness. HRSD total score and cognitive and vegetative factor scores were significantly higher in the evening chronotype than in the morning and intermediate chronotypes (p < .001). In the regression analysis, MEQ total score was inversely related to HRSD-vegetative factor score (p < .001). The ratio of comorbid illness was found to be statistically significant among depressed patients with evening chronotype (p = .001). Additionally, binary logistic regression analysis was performed to ascertain the likelihood of participants having comorbid medical illness; only age (p = .010) and MEQ total score (p = .011) were associated with exhibiting comorbid illness. General and psychiatric clinical examinations need to be considered with the understanding of circadian preference.
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    Evidence for an association of serum melatonin concentrations with recognition and circadian preferences in patients with schizophrenia.
    (2019-06-01) SAHBAZ, C; Özer, OF; KURTULMUS, AYŞE; KıRPıNAR, I; SAHIN, F; GULOKSUZ, S; ŞAHBAZ, ÇIĞDEM DILEK; ÖZER, ÖMER FARUK; KURTULMUŞ, AYŞE; KIRPINAR, İSMET