Person: ŞAHBAZ, ÇIĞDEM DILEK
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Is there an association between theory of mind ability and biological rhythm disturbances in individuals with schizophrenia?
2018-03-01T00:00:00Z, Sahbaz, C., Kurtulmus, A., Kirpinar, I., ŞAHBAZ, ÇIĞDEM DILEK, KIRPINAR, İSMET
Reduced regulatory T cells with increased proinflammatory response in patients with schizophrenia
2020-06-01T00:00:00Z, Sahbaz, Cigdem, Zibandey, Noushin, KURTULMUŞ, AYŞE, Duran, Yazgul, Gokalp, Muazzez, KIRPINAR, İSMET, ŞAHİN, FİKRETTİN, Guloksuz, Sinan, AKKOÇ, TUNÇ, ŞAHBAZ, ÇIĞDEM DILEK, KURTULMUŞ, AYŞE, KIRPINAR, İSMET
Aim To investigate whether circulating T cells including regulatory T cells (Treg) and derived cytokines contribute to the immune imbalance observed in schizophrenia. Methods Forty patients with schizophrenia and 40 age, sex, body mass index, education, and smoking status-matched healthy controls (HC) are included in the study. We stained cells with anti-CD14, anti-CD3, anti-CD4, anti-CD8, anti-CD19, anti-CD20, and anti-CD16/56. Peripheral blood mononuclear cells (PBMCs) were isolated and stained with the human FoxP3 kit containing anti-CD4/anti-CD25 and intracellular anti-Foxp3. PBMCs were cultured for 72 h and stimulated with anti-CD3/anti-CD28. Cytokines (IL-2, IL-4, IL-6, IL-10, IFN-gamma, TNF-alpha, and IL-17A) were measured from the culture supernatant and plasma using the Th1/Th2/Th17 cytokine bead array kit. Results In comparison with HC, Treg percentages in schizophrenia were higher (1.17 +/- 0.63 vs 0.81 +/- 0.53, P = 0.005) in unstimulated but lower in the stimulated condition (0.73 +/- 0.69 vs 0.97 +/- 0.55, P = 0.011). Activated T cell percentages were higher in schizophrenia than HC in unstimulated (2.22 +/- 0.78 vs 1.64 +/- 0.89, P = 0.001) and stimulated (2.25 +/- 1.01 vs 1.72 +/- 1.00, P = 0.010) conditions. The culture supernatant levels of IL-6 (7505.17 +/- 5170.07 vs 1787.81 +/- 1363.32, P < 0.001), IL-17A (191.73 +/- 212.49 vs 46.43 +/- 23.99, P < 0.001), TNF-alpha (1557 +/- 1059.69 vs 426.57 +/- 174.62, P = 0.023), and IFN-gamma (3204.13 +/- 1397.06 vs 447.79 +/- 270.13, P < 0.001); and plasma levels of IL-6 (3.83 +/- 3.41vs 1.89 +/- 1.14, P = 0.003) and IL-17A (1.20 +/- 0.84 vs 0.83 +/- 0.53, P = 0.033) were higher in patients with schizophrenia than HC. Conclusion Our explorative study shows reduced level of Foxp3 expressing Treg in a stimulated condition with induced levels of proinflammatory cytokines in patients with schizophrenia.
Effect of chronotype on academical performance of medical students
2019-04-01, Darbaz, B., Topal, A., ŞAHBAZ, Çiğdem Dilek, ŞAHBAZ, ÇIĞDEM DILEK
Evening Chronotype Is Associated with Medical Comorbities and Factor Structure of Depression: A Descriptive Study
2018-06-24, ŞAHBAZ, ÇİĞDEM DİLEK, ŞAHBAZ, ÇIĞDEM DILEK
Necroptosis Might be a Time Dependent Neuronal Cell Death Mechanism on Hippocampus After Chronic Restraint Stress
2019-05-15, Sahbaz, Cigdem, ELİBOL, BİRSEN, ŞAHBAZ, ÇIĞDEM DILEK, ELİBOL, BİRSEN
Chronotype anc Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome
2021-01-01T00:00:00Z, GÖKMEN KARASU, AYŞE FİLİZ, Sahbaz, Cigdem Dilek, Dogu, Zeynep Filiz Eren, TAKMAZ, TAHA, ÇALI, HALİME, Tanoglu, Basak, GÖKMEN KARASU, AYŞE FİLİZ, ŞAHBAZ, ÇIĞDEM DILEK, TAKMAZ, TAHA, ÇALI, HALİME
Aim: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder among women during the reproductive ages. The purpose of this study was to investigate the chronotype and sleep quality of PCOS patients.
Attachment styles and theory of mind abilities non-psychotic adult offspring of patients with schizophrenia
2019-04-09, ŞAHBAZ, ÇİĞDEM DİLEK, ŞAHBAZ, ÇIĞDEM DILEK
A role of T cell subsets in the immun dysfunction of schizophrenia
2018-03-01T00:00:00Z, Sahbaz, C., Zibandeh, N., Kurtulmus, A., Kirpinar, I., Sahin, F., Akkoc, T., ŞAHBAZ, ÇIĞDEM DILEK, KIRPINAR, İSMET
Biological rhythm disturbances in major depressive disorder
2019-04-01, Ozcelik, A. M., ŞAHBAZ, Çiğdem Dilek, ŞAHBAZ, ÇIĞDEM DILEK
Role of Lymphocyte Subsets and T-Cell Profiles in the Immune Dysfunction of Schizophrenia
2018-05-01, SAHBAZ, Cigdem, Zibandeyeh, Noushin, Kurtulmus, AYŞE, AVAROGLU, Gamze, Kirpinar, Ismet, Sahin, Fikrettin, AKKOÇ, TUNÇ, ŞAHBAZ, ÇIĞDEM DILEK, KURTULMUŞ, AYŞE, KIRPINAR, İSMET