Person: ŞAHBAZ, ÇIĞDEM DILEK
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Publication Metadata only Is there an association between theory of mind ability and biological rhythm disturbances in individuals with schizophrenia?(2018-03-01T00:00:00Z) Sahbaz, C.; Kurtulmus, A.; Kirpinar, I.; ŞAHBAZ, ÇIĞDEM DILEK; KIRPINAR, İSMETPublication Metadata only A role of T cell subsets in the immun dysfunction of schizophrenia(2018-03-01T00:00:00Z) Sahbaz, C.; Zibandeh, N.; Kurtulmus, A.; Kirpinar, I.; Sahin, F.; Akkoc, T.; ŞAHBAZ, ÇIĞDEM DILEK; KIRPINAR, İSMETPublication Metadata only Biological rhythm disturbances in major depressive disorder(2019-04-01) Ozcelik, A. M.; ŞAHBAZ, Çiğdem Dilek; ŞAHBAZ, ÇIĞDEM DILEKPublication Metadata only Effect of chronotype on academical performance of medical students(2019-04-01) Darbaz, B.; Topal, A.; ŞAHBAZ, Çiğdem Dilek; ŞAHBAZ, ÇIĞDEM DILEKPublication Metadata only Thymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the Aβ(1–42)-infused rat model of Alzheimer-s disease(2019-10-01) Elibol, Birsen; Şahbaz, Çiğdem Dilek; Beker, Merve; Terzioğlu, Şule; ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; BEKER, MERVE; ŞAHBAZ, ÇIĞDEM DILEKOBJECTIVES: Alzheimer-s disease (AD) is a severe neurodegenerative disease with presentation of the neuronal death, memory loss and cognitive decline. The relationship between neuroinflammation and AD has been well documented. However, the options of anti-inflammatory treatment are very limited in patients with AD. Previous studies showed that flavonoids might be an effective treatment and thymoquinone (TQ), an aromatic hydrocarbon found in Nigella sativa suggested as a candidate molecule due to having strong anti-inflammatory effects. Our study aimed to investigate the effects of TQ on neuroinflammation and neuroprotection in A beta((1-42)) infused rat model of AD.Publication Metadata only Circadian preferences are associated with vegetative symptoms and comorbid medical diseases in patients with major depression(2019-09-03) Sahbaz, Çiğdem Dilek; Devetzioglou, Tougmpa; Ozcelik, Ayse Mine; KIRPINAR, İSMET; ŞAHBAZ, ÇIĞDEM DILEK; KIRPINAR, İSMETCircadian preferences may affect the severity and symptom structure of depression and could influence specific symptom clusters of depression. This study aims to examine the relationship between chronotypes and symptomatology in patients with major depression. One hundred and one drug-naive outpatients with major depression were evaluated through the use of the Hamilton Rating Scale for Depression (HRSD). The Morningness-Eveningness Questionnaire (MEQ) was used to the define chronotypes and the quality of subjective sleep was measured with Pittsburgh Sleep Quality Index (PSQI). The medical records of patients were evaluated retrospectively to determine the presence of another medical illness. HRSD total score and cognitive and vegetative factor scores were significantly higher in the evening chronotype than in the morning and intermediate chronotypes (p < .001). In the regression analysis, MEQ total score was inversely related to HRSD-vegetative factor score (p < .001). The ratio of comorbid illness was found to be statistically significant among depressed patients with evening chronotype (p = .001). Additionally, binary logistic regression analysis was performed to ascertain the likelihood of participants having comorbid medical illness; only age (p = .010) and MEQ total score (p = .011) were associated with exhibiting comorbid illness. General and psychiatric clinical examinations need to be considered with the understanding of circadian preference.Publication Open Access Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus.(2019-01-01) Sahbaz, CD; Elibol, BİRSEN; Beker, M; Kilic, U; Jakubowska-Doğru, E; ELİBOL, BİRSEN; ŞAHBAZ, ÇIĞDEM DILEKIt is well known that the fetal ethanol exposure and prenatal stress may have adverse effects on brain development. Interestingly, some morphological and functional recovery from their teratogenic effects that take place during brain maturation. However, mechanisms that underlie this recovery are not fully elucidated. The aim of this study was to examine whether the postnatal attenuation of fetal alcohol - and maternal stress‑induced morphological and functional deficits correlates with compensatory changes in the expression/activation of the brain proteins involved in inflammation, cell survival and apoptosis. In this project, we investigated the hippocampus which belongs to the brain regions most susceptible to the adverse effects of prenatal ethanol exposure. Pregnant rat dams were administered ethanol (A) or isocaloric glucose solution (IC) by a gastric intubation during gestational days 7-20. The pure control group received ad libitum laboratory chow and water with no other treatment. The hippocampi of fetal-ethanol and control pups were examined at the postnatal day (PD)1, PD10, PD30 and PD60. Moderate fetal-ethanol exposure and prenatal intubation stress caused a significant increase in molecular factors relating to inflammation (iNOS) and cell survival/apoptosis pathways (PTEN, GSK-3 and ERK) at birth, with a rapid compensation from these developmental deficits upon removal of alcohol at PD10. Indeed, an increase in ERK1/2 and JNK1/2 activation at PD30 was observed with ethanol consumption. It indicates that the recovery process in A and IC brains started soon after the birth upon the ethanol and stressor withdrawal and continued until the adulthood.Publication Metadata only Evidence for an association of serum melatonin concentrations with recognition and circadian preferences in patients with schizophrenia.(2019-06-01) SAHBAZ, C; Özer, OF; KURTULMUS, AYŞE; KıRPıNAR, I; SAHIN, F; GULOKSUZ, S; ŞAHBAZ, ÇIĞDEM DILEK; ÖZER, ÖMER FARUK; KURTULMUŞ, AYŞE; KIRPINAR, İSMETPublication Metadata only Association between emotional functioning and biological rhythm disruptions in patients with schizophrenia(2019-11-01) Sahbaz, Çiğdem Dilek; Kurtulmus, Ayse; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞEObjective: Dysregulation of biological rhythm is associated with reduced executive functioning and potentiating psychosis, which are essential for the Theory of Mind (ToM) among patients with schizophrenia. However, the association between cognitive dysfunction, emotional information and disruption of biological rhythm remains uncertain. Methods: Forty-one patients with schizophrenia and forty age, gender and smoking status-matched healthy controls were recruited into the study. The Wisconsin Card Sorting Test (WCST), The Stroop test, The Reading the Mind in the Eyes Test (RMET), The Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) were used. Results: BRIAN total, sleep, activity and social scores were higher in patients with schizophrenia than healthy controls. Higher BRIAN score was correlated with lower RMET score; with higher PANSS total, positive and negative scores, and not correlated with executive functions. In the regression analysis, it was observed that gender and increased BRIAN score was independently associated with lower scores for RMET in a patient with schizophrenia. Conclusion: These results suggest that the disruption of biological rhythm might be associated with ToM in patients with schizophrenia. Future research should examine the relationship between biological rhythm and ToM to determine if any causal associations can be identified.Publication Metadata only Intergenerational transmission of health disparities among Turkish-origin residents in Germany: role of maternal stress and stress biology during pregnancy. A study protocol(2018-05-01) Scholaske, L.; Lindner-Matthes, D.; Kurt, M.; Duman, E.; ŞAHBAZ, Çiğdem Dilek; Spallek, J.; Entringer, S.; ŞAHBAZ, ÇIĞDEM DILEK