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ŞAHBAZ, ÇIĞDEM DILEK

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ÇIĞDEM DILEK
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ŞAHBAZ
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2018 - 20204
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Author: KURTULMUŞ, AYŞE ×

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    Reduced regulatory T cells with increased proinflammatory response in patients with schizophrenia
    (2020-06-01T00:00:00Z) Sahbaz, Cigdem; Zibandey, Noushin; KURTULMUŞ, AYŞE; Duran, Yazgul; Gokalp, Muazzez; KIRPINAR, İSMET; ŞAHİN, FİKRETTİN; Guloksuz, Sinan; AKKOÇ, TUNÇ; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞE; KIRPINAR, İSMET
    Aim To investigate whether circulating T cells including regulatory T cells (Treg) and derived cytokines contribute to the immune imbalance observed in schizophrenia. Methods Forty patients with schizophrenia and 40 age, sex, body mass index, education, and smoking status-matched healthy controls (HC) are included in the study. We stained cells with anti-CD14, anti-CD3, anti-CD4, anti-CD8, anti-CD19, anti-CD20, and anti-CD16/56. Peripheral blood mononuclear cells (PBMCs) were isolated and stained with the human FoxP3 kit containing anti-CD4/anti-CD25 and intracellular anti-Foxp3. PBMCs were cultured for 72 h and stimulated with anti-CD3/anti-CD28. Cytokines (IL-2, IL-4, IL-6, IL-10, IFN-gamma, TNF-alpha, and IL-17A) were measured from the culture supernatant and plasma using the Th1/Th2/Th17 cytokine bead array kit. Results In comparison with HC, Treg percentages in schizophrenia were higher (1.17 +/- 0.63 vs 0.81 +/- 0.53, P = 0.005) in unstimulated but lower in the stimulated condition (0.73 +/- 0.69 vs 0.97 +/- 0.55, P = 0.011). Activated T cell percentages were higher in schizophrenia than HC in unstimulated (2.22 +/- 0.78 vs 1.64 +/- 0.89, P = 0.001) and stimulated (2.25 +/- 1.01 vs 1.72 +/- 1.00, P = 0.010) conditions. The culture supernatant levels of IL-6 (7505.17 +/- 5170.07 vs 1787.81 +/- 1363.32, P < 0.001), IL-17A (191.73 +/- 212.49 vs 46.43 +/- 23.99, P < 0.001), TNF-alpha (1557 +/- 1059.69 vs 426.57 +/- 174.62, P = 0.023), and IFN-gamma (3204.13 +/- 1397.06 vs 447.79 +/- 270.13, P < 0.001); and plasma levels of IL-6 (3.83 +/- 3.41vs 1.89 +/- 1.14, P = 0.003) and IL-17A (1.20 +/- 0.84 vs 0.83 +/- 0.53, P = 0.033) were higher in patients with schizophrenia than HC. Conclusion Our explorative study shows reduced level of Foxp3 expressing Treg in a stimulated condition with induced levels of proinflammatory cytokines in patients with schizophrenia.
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    Role of Lymphocyte Subsets and T-Cell Profiles in the Immune Dysfunction of Schizophrenia
    (2018-05-01) SAHBAZ, Cigdem; Zibandeyeh, Noushin; Kurtulmus, AYŞE; AVAROGLU, Gamze; Kirpinar, Ismet; Sahin, Fikrettin; AKKOÇ, TUNÇ; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞE; KIRPINAR, İSMET
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    Evidence for an association of serum melatonin concentrations with recognition and circadian preferences in patients with schizophrenia.
    (2019-06-01) SAHBAZ, C; Özer, OF; KURTULMUS, AYŞE; KıRPıNAR, I; SAHIN, F; GULOKSUZ, S; ŞAHBAZ, ÇIĞDEM DILEK; ÖZER, ÖMER FARUK; KURTULMUŞ, AYŞE; KIRPINAR, İSMET
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    Association between emotional functioning and biological rhythm disruptions in patients with schizophrenia
    (2019-11-01) Sahbaz, Çiğdem Dilek; Kurtulmus, Ayse; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞE
    Objective: Dysregulation of biological rhythm is associated with reduced executive functioning and potentiating psychosis, which are essential for the Theory of Mind (ToM) among patients with schizophrenia. However, the association between cognitive dysfunction, emotional information and disruption of biological rhythm remains uncertain. Methods: Forty-one patients with schizophrenia and forty age, gender and smoking status-matched healthy controls were recruited into the study. The Wisconsin Card Sorting Test (WCST), The Stroop test, The Reading the Mind in the Eyes Test (RMET), The Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) were used. Results: BRIAN total, sleep, activity and social scores were higher in patients with schizophrenia than healthy controls. Higher BRIAN score was correlated with lower RMET score; with higher PANSS total, positive and negative scores, and not correlated with executive functions. In the regression analysis, it was observed that gender and increased BRIAN score was independently associated with lower scores for RMET in a patient with schizophrenia. Conclusion: These results suggest that the disruption of biological rhythm might be associated with ToM in patients with schizophrenia. Future research should examine the relationship between biological rhythm and ToM to determine if any causal associations can be identified.