Person: ŞAHBAZ, ÇIĞDEM DILEK
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ŞAHBAZ
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ÇIĞDEM DILEK
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- PublicationMetadata onlyIntergenerational transmission of health disparities among Turkish-origin residents in Germany: role of maternal stress and stress biology during pregnancy. A study protocol(2018-05-01) Scholaske, L.; Lindner-Matthes, D.; Kurt, M.; Duman, E.; ŞAHBAZ, Çiğdem Dilek; Spallek, J.; Entringer, S.; ŞAHBAZ, ÇIĞDEM DILEK
- PublicationMetadata onlyEffect of chronotype on academical performance of medical students(2019-04-01) Darbaz, B.; Topal, A.; ŞAHBAZ, Çiğdem Dilek; ŞAHBAZ, ÇIĞDEM DILEK
- PublicationMetadata onlyBiological rhythm disturbances in major depressive disorder(2019-04-01) Ozcelik, A. M.; ŞAHBAZ, Çiğdem Dilek; ŞAHBAZ, ÇIĞDEM DILEK
- PublicationMetadata onlyThymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the Aβ(1–42)-infused rat model of Alzheimer-s disease(2019-10-01) Elibol, Birsen; Şahbaz, Çiğdem Dilek; Beker, Merve; Terzioğlu, Şule; ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; BEKER, MERVE; ŞAHBAZ, ÇIĞDEM DILEKOBJECTIVES: Alzheimer-s disease (AD) is a severe neurodegenerative disease with presentation of the neuronal death, memory loss and cognitive decline. The relationship between neuroinflammation and AD has been well documented. However, the options of anti-inflammatory treatment are very limited in patients with AD. Previous studies showed that flavonoids might be an effective treatment and thymoquinone (TQ), an aromatic hydrocarbon found in Nigella sativa suggested as a candidate molecule due to having strong anti-inflammatory effects. Our study aimed to investigate the effects of TQ on neuroinflammation and neuroprotection in A beta((1-42)) infused rat model of AD.
- PublicationMetadata onlyCircadian preferences are associated with vegetative symptoms and comorbid medical diseases in patients with major depression(2019-09-03) Sahbaz, Çiğdem Dilek; Devetzioglou, Tougmpa; Ozcelik, Ayse Mine; KIRPINAR, İSMET; ŞAHBAZ, ÇIĞDEM DILEK; KIRPINAR, İSMETCircadian preferences may affect the severity and symptom structure of depression and could influence specific symptom clusters of depression. This study aims to examine the relationship between chronotypes and symptomatology in patients with major depression. One hundred and one drug-naive outpatients with major depression were evaluated through the use of the Hamilton Rating Scale for Depression (HRSD). The Morningness-Eveningness Questionnaire (MEQ) was used to the define chronotypes and the quality of subjective sleep was measured with Pittsburgh Sleep Quality Index (PSQI). The medical records of patients were evaluated retrospectively to determine the presence of another medical illness. HRSD total score and cognitive and vegetative factor scores were significantly higher in the evening chronotype than in the morning and intermediate chronotypes (p < .001). In the regression analysis, MEQ total score was inversely related to HRSD-vegetative factor score (p < .001). The ratio of comorbid illness was found to be statistically significant among depressed patients with evening chronotype (p = .001). Additionally, binary logistic regression analysis was performed to ascertain the likelihood of participants having comorbid medical illness; only age (p = .010) and MEQ total score (p = .011) were associated with exhibiting comorbid illness. General and psychiatric clinical examinations need to be considered with the understanding of circadian preference.
- PublicationMetadata onlyRole of Lymphocyte Subsets and T-Cell Profiles in the Immune Dysfunction of Schizophrenia(2018-05-01) SAHBAZ, Cigdem; Zibandeyeh, Noushin; Kurtulmus, AYŞE; AVAROGLU, Gamze; Kirpinar, Ismet; Sahin, Fikrettin; AKKOÇ, TUNÇ; ŞAHBAZ, ÇIĞDEM DILEK; KURTULMUŞ, AYŞE; KIRPINAR, İSMET
- PublicationMetadata onlyEvening Chronotype Is Associated with Medical Comorbities and Factor Structure of Depression: A Descriptive Study(2018-06-24) ŞAHBAZ, ÇİĞDEM DİLEK; ŞAHBAZ, ÇIĞDEM DILEK
- PublicationOpen AccessClinical evaluation of biological rhythm domains in patients with major depression(2020-05-01T00:00:00Z) Ozcelik, Mine; Sahbaz, Cigdem; ŞAHBAZ, ÇIĞDEM DILEKObjective: Sleep, physical activity, and social domains of biological rhythm disruptions may have specific effects on the symptom cluster and severity of depression. However, there is a lack of structured clinical evaluation to specify the domains of biological rhythms in patients with depression. Methods: Ninety drug-naïve subjects with depression and 91 matched healthy controls were recruited for the study. The severity of depression was examined with the Hamilton Rating Scale for Depression (HRSD), while biological rhythm was evaluated using the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN). Results: Patients with depression showed significantly greater biological rhythm disturbances than healthy controls in all domains of BRIAN (sleep, activity, social, and eating). BRIAN-Total correlated positively with HRSD-Total and HRSD-Total without sleep cluster. The sleep and activity domains correlated significantly with HRSD-Total score. Additionally, the sleep, activity, and social domains correlated significantly with HRSD-Total without the sleep cluster score. Regression analysis revealed the activity (β = 0.476, t = 5.07, p<0.001) and sleep (β = 0.209, t = 2.056, p = 0.043) domains may predict HRSD-Total score.
- PublicationMetadata onlyA role of T cell subsets in the immun dysfunction of schizophrenia(2018-03-01T00:00:00Z) Sahbaz, C.; Zibandeh, N.; Kurtulmus, A.; Kirpinar, I.; Sahin, F.; Akkoc, T.; ŞAHBAZ, ÇIĞDEM DILEK; KIRPINAR, İSMET
- PublicationOpen AccessChronotype and Sleep Quality in Patients with Inflammatory Bowel Disease(2020-01-01T00:00:00Z) Keskin, Elmas; Sahbaz, Cigdem Dilek; BİBERCİ KESKİN, ELMAS; ŞAHBAZ, ÇIĞDEM DILEKAim: Chronotype and sleep disturbance are both considered risk factors for chronic autoimmune diseases. However, there is lack of knowledge with respect to chronic inflammatory bowel disease and chronotype patterns. Therefore, we investigated the chronotype and sleep quality in patients with ulcerative colitis and Crohn-s disease.