Person: UZUNER, SELÇUK
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Akut Poststreptokoksik Glomerulonefrite Bağlı Gelişen Posterior reverzibl Ensefalopati Olgusu
Hematological indices for differential diagnosis of Beta thalassemia trait and iron deficiency anemia.
Background. The two most frequent types of microcytic anemia are beta thalassemia trait (𝛽-TT) and iron deficiency anemia (IDA). We retrospectively evaluated the reliability of various indices for differential diagnosis of microcytosis and 𝛽-TT in the same patient groups. Methods. A total of 290 carefully selected children aged 1.1–16 years were evaluated. We calculated 12 discrimination indices in all patients with hemoglobin (Hb) values of 8.7–11.4 g/dL. None of the subjects had a combined case of IDA and 𝛽-TT. All children with IDA received oral iron for 16 weeks, and HbA2 screening was performed after iron therapy. The patient groups were evaluated according to red blood cell (RBC) count; red blood distribution width index; the Mentzer, Shine and Lal, England and Fraser, Srivastava and Bevington, Green and King, Ricerca, Sirdah, and Ehsani indices; mean density of hemoglobin/liter of blood; and mean cell density of hemoglobin. Results. The Mentzer index was the most reliable index, as it had the highest sensitivity (98.7%), specificity (82.3%), and Youden’s index (81%) for detecting 𝛽-TT; this was followed by the Ehsani index (94.8%, 73.5%, and 68.3%, resp.) and RBC count (94.8%, 70.5%, and 65.3%). Conclusion.The Mentzer index provided the highest reliabilities for differentiating 𝛽-TT from IDA.
Evaluation of Autonomic Nervous System function in Children with Overactive Bladder Syndrome
Purpose We aimed to evaluate the autonomic nervous system activity in children with overactive bladder (OAB) syndrome.Methods Included in the study were 40 children with overactive bladder and 28 healthy controls. Autonomic tests were performed on all participants, including heart rate interval variation (RRIV), heart rate response to valsalva maneuver, and sympathetic skin response (SSR).Results Mean valsalva rates in the overactive bladder and control groups were 1.530.29 and 1.30 +/- 0.18, respectively, a statistically significant difference (P0.05).Conclusions This study demonstrated a parasympathetic hyperactivity in children with OAB, results suggesting a dysfunction in their autonomic nervous systems. (C) 2016 Wiley Periodicals, Inc.
The different cutaneous presentations in three cases of Kawasaki disease as confounding factor of diagnosis.
çocukta kayısı sülfirizasyonuna bağlı kronik trakeal ödem ve solunum sıkıntısı
Association between myeloperoxidase gene polymorphism and familial mediterranean fever in Turkish Children
Background: Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease. Autoinflammatory disorders are characterized by exaggerated immune system responses. Neutrophils and their byproduct, myeloperoxidase, are important components of the innate immune system. In the present study, we searched for myeloperoxidase gene polymorphisms in FMF patients. Methodology/Principal Findings: We evaluated 83 children diagnosed with FMF by their physicians and 93 controls without any family history of FMF. MPO gene polymorphisms were detected using polymerase chain reaction (PCR)-based methods. We genotyped all samples in terms of the -463G/A single-nucleotide polymorphism, the most extensively studied MPO polymorphism. Allelic and genotypic frequencies were calculated, and possible associations with FMF explored. The frequencies of MPO polymorphisms differed significantly between the study and control groups (P = 0.003). The AA and AG gene polymorphisms were more prevalent in the FMF group than in the controls. The A allele was more prevalent in the FMF group (P = 0.001), and the frequency of the G allele was similar between the two groups (P = 0.128). Conclusion: MPO gene polymorphisms and allelic differences may be important in the pathogenesis of FMF.