Person: UZUNER, SELÇUK
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Publication Open Access Hematological indices for differential diagnosis of Beta thalassemia trait and iron deficiency anemia.(2014-01-01) OZGURHAN, G; DEMIR, AD; Uzuner, SELÇUK; NURSOY, MUSTAFA ATİLLA; TURKMEN, S; KACAN, A; VEHAPOĞLU TÜRKMEN, AYSEL; UZUNER, SELÇUK; NURSOY, MUSTAFA ATİLLABackground. The two most frequent types of microcytic anemia are beta thalassemia trait (𝛽-TT) and iron deficiency anemia (IDA). We retrospectively evaluated the reliability of various indices for differential diagnosis of microcytosis and 𝛽-TT in the same patient groups. Methods. A total of 290 carefully selected children aged 1.1–16 years were evaluated. We calculated 12 discrimination indices in all patients with hemoglobin (Hb) values of 8.7–11.4 g/dL. None of the subjects had a combined case of IDA and 𝛽-TT. All children with IDA received oral iron for 16 weeks, and HbA2 screening was performed after iron therapy. The patient groups were evaluated according to red blood cell (RBC) count; red blood distribution width index; the Mentzer, Shine and Lal, England and Fraser, Srivastava and Bevington, Green and King, Ricerca, Sirdah, and Ehsani indices; mean density of hemoglobin/liter of blood; and mean cell density of hemoglobin. Results. The Mentzer index was the most reliable index, as it had the highest sensitivity (98.7%), specificity (82.3%), and Youden’s index (81%) for detecting 𝛽-TT; this was followed by the Ehsani index (94.8%, 73.5%, and 68.3%, resp.) and RBC count (94.8%, 70.5%, and 65.3%). Conclusion.The Mentzer index provided the highest reliabilities for differentiating 𝛽-TT from IDA.Publication Metadata only Evaluation of Autonomic Nervous System function in Children with Overactive Bladder Syndrome(2017-03-01) DEMIR, Aysegul Dogan; Gursoy, AZİZE ESRA; GOKNAR, Nilufer; Uzuner, SELÇUK; Ozkaya, EMİN; Erenberk, UFUK; Vehapoglu, Aysel; DUNDAROZ, Mehmet Rusen; OKTEM, Faruk; GÜRSOY, AZIZE ESRA; UZUNER, SELÇUK; ÖZKAYA, EMİN; ERENBERK, UFUK; VEHAPOĞLU TÜRKMEN, AYSELPurpose We aimed to evaluate the autonomic nervous system activity in children with overactive bladder (OAB) syndrome.Methods Included in the study were 40 children with overactive bladder and 28 healthy controls. Autonomic tests were performed on all participants, including heart rate interval variation (RRIV), heart rate response to valsalva maneuver, and sympathetic skin response (SSR).Results Mean valsalva rates in the overactive bladder and control groups were 1.530.29 and 1.30 +/- 0.18, respectively, a statistically significant difference (P0.05).Conclusions This study demonstrated a parasympathetic hyperactivity in children with OAB, results suggesting a dysfunction in their autonomic nervous systems. (C) 2016 Wiley Periodicals, Inc.Publication Metadata only Association between myeloperoxidase gene polymorphism and familial mediterranean fever in Turkish Children(2016-01-01) DEMIR, Aysegul Dogan; GOKNAR, Nilufer; OKTEM, Faruk; Ergen, Hayriye Arzu; Dogan, Akif Nuri; Uzuner, SELÇUK; Vehapoglu, Aysel; Yazici, MEBRURE; UZUNER, SELÇUK; VEHAPOĞLU TÜRKMEN, AYSEL; YAZICI, MEBRUREBackground: Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease. Autoinflammatory disorders are characterized by exaggerated immune system responses. Neutrophils and their byproduct, myeloperoxidase, are important components of the innate immune system. In the present study, we searched for myeloperoxidase gene polymorphisms in FMF patients. Methodology/Principal Findings: We evaluated 83 children diagnosed with FMF by their physicians and 93 controls without any family history of FMF. MPO gene polymorphisms were detected using polymerase chain reaction (PCR)-based methods. We genotyped all samples in terms of the -463G/A single-nucleotide polymorphism, the most extensively studied MPO polymorphism. Allelic and genotypic frequencies were calculated, and possible associations with FMF explored. The frequencies of MPO polymorphisms differed significantly between the study and control groups (P = 0.003). The AA and AG gene polymorphisms were more prevalent in the FMF group than in the controls. The A allele was more prevalent in the FMF group (P = 0.001), and the frequency of the G allele was similar between the two groups (P = 0.128). Conclusion: MPO gene polymorphisms and allelic differences may be important in the pathogenesis of FMF.Publication Open Access The different cutaneous presentations in three cases of Kawasaki disease as confounding factor of diagnosis(2016-09-01) DEMIR, Aysegul Dogan; GOKNAR, Nilufer; Uzuner, SELÇUK; Vehapoglu, Aysel; Saritas, Turkay; OKTEM, Faruk; UZUNER, SELÇUK; VEHAPOĞLU TÜRKMEN, AYSELWe report three paediatric cases of Kawasaki disease (KD). Erythema multiforme (EM) was the presenting cutaneous feature in two patients, with young age (43 days old), macular rash and meningitis in the third patient. Diagnosis of KD was difficult due either to initial misdiagnosis of drug eruption, incomplete presentation, or the young age of the patient. Clinicians should be aware of these cutaneous presentations to prevent KD complications.