Person: MERAL, İSMAİL
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Publication Metadata only Kardiyovasküler Hastalıklarda Biyotinidaz ve TCA Enzim Aktivitelerinin İncelenmesi(2023-07-09) Sarıkaya U.; Çimen Y. A.; Taşlıdere B.; Selek Ş.; Açıkgöz N.; Meral İ.; SARIKAYA, UFUK; ÇİMEN, YASİN ALİ; TAŞLIDERE, BAHADIR; SELEK, ŞAHABETTİN; AÇIKGÖZ, NUSRET; MERAL, İSMAİLPublication Metadata only Raftlin, presepsin levels and thiol-disulfide homeostasis in acute appendicitis: A pilot study(2018-11-01) KOÇYİĞİT, ABDÜRRAHİM; ERSOY, YELİZ EMİNE; SELEK, ŞAHBETTİN; SÜMBÜL, BİLGE; ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; MERAL, İSMAİL; YİĞİT, MEHMET; ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; MERAL, İSMAİL; SÜMBÜL, BİLGE; SELEK, ŞAHABETTİN; ERSOY, YELIZ EMINEObjective: To investigate some of the new inflammatory and oxidative stress markers in acute appendicitis.Publication Metadata only Sulodexide protected the heart against ischemia/reperfusion injury by reducing oxidative stress, inflammation, and apoptosis in the isolated rat heart(2022-11-17) ÜSTÜNOVA S.; AKSOY R.; BULUT H.; KILIÇ A.; MERAL İ.; RABUŞ M. B.; BOZKURT A. K.; KÖKSAL C.; ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSU; MERAL, İSMAİL; KÖKSAL, CENGİZPublication Metadata only Effects of Thymoquinone On Erythrocyte Aggregation Kinetics: An In Vitro Study(2022-01-01T00:00:00Z) ÜSTÜNOVA, SAVAŞ; Uyuklu, Mehmet; MERAL, İSMAİL; ÜSTÜNOVA, SAVAŞ; MERAL, İSMAİL© 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Erythrocyte aggregation is associated with a series of physio-pathological processes in body and according to this, current study was designed to examine how the thymoquinone (TQ) and a ggregation kinetics relation changes when the aggregation properties of erythrocyte suspensions are intervened using different approaches, such as changing the suspension environment or erythrocyte surface properties. Blood samples from 40 male Wistar albino rats (three months old weighing 250-300 g) were randomly divided into four groups, as 1) whole blood (control), 2) 1/2 dilution (plasma was diluted with PBS), 3) dextran 500 (1% dextran 500 was dissolved in plasma) and 4) glutaraldehyde. Blood samples were taken from abdominal aorta under anesthesia. The erythrocyte suspensions were incubated at 37°C for one hour in the absence or presence of TQ, with a final concentration of 1 mg/ml. Then, the electrical properties of erythrocyte suspensions were recorded, and the electrical capacitance was monitored using an inductance, capacitance, and resistance meter (LCR meter) at 100 kHz. It was found that TQ incubation decreased the aggregation index in control and dextran groups while increased it in 1/2 dilution and GA groups. It was also found that TQ incubation increased the time constant in whole blood and dextran while decreased it in 1/2 dilution and GA. The TQ can normalize the altered erythrocyte aggregation responses in both ways that is, it decreases the increased aggregation or increases the decreased aggregation. Therefore, it may have very critical role in rouleaux formation-induced circulatory disorders.Publication Metadata only Serum Electrolyte Values and Blood Oxidative Stress Parameters in Patients with Focal and Generalized Epilepsy(2023-02-01) Sarı G.; Kılıç A.; Uslu F.; Selek Ş.; Üstünova S.; Meral İ.; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; MERAL, İSMAİLPublication Open Access Peripheral mononuclear leukocyte DNA damage, plasma prolidase activity, and oxidative status in patients with benign prostatic hyperplasia(2015-07-01) Gecit, Ilhan; Meral, Ismail; Aslan, Mehmet; Uyuklu, MEHMET; Taskin, Abdullah; Kaba, Mehmet; Pirincci, Necip; Gunes, Mustafa; Taken, Kerem; Demir, Halit; Ceylan, Kadir; MERAL, İSMAİL; KOÇYİĞİT, ABDÜRRAHİM; ÜYÜKLÜ, MEHMETObjectives: Prolidase plays a major role in collagen turnover, matrix remodeling, and cell growth. Benign prostatic hyperplasia (BPH) may be associated with an increased extracellular matrix deposition. Therefore, the present study was designed to investigate the plasma prolidase activity, oxidative status, and peripheral mononuclear leukocyte DNA damage in patients with BPH.Publication Metadata only Effect of Short-term 900 MHz low level electromagnetic radiation exposure on blood serotonin and glutamate levels(2015-01-01T00:00:00Z) Eris, A. H.; Kiziltan, H. S.; Meral, I; Gene, H.; Trabzon, M.; Seyithanoglu, H.; Yagci, B.; Uysal, O.; MERAL, İSMAİL; SEYİTHANOĞLU, MEHMET HAKANBackground: Long term exposure to low level electromagnetic radiation (LLER) by using cellular phones causes serious health problems.Publication Metadata only Short-term levosimendan treatment protects rat testes against oxidative stress(2012-08-01T00:00:00Z) Yuksel, M. B.; Kavak, S.; Gecit, I.; Basel, H.; Gumrukcuoglu, H. A.; Demir, Halit; Meral, I.; MERAL, İSMAİLThe objective of this study was to evaluate the effect of short-term levosimendan exposure on oxidant/antioxidant status and trace element levels in the testes of rats under physiological conditions. Twenty male Wistar albino rats were randomly divided into two groups of 10 animals each. Group 1 was not exposed to levosimendan and served as control. Levosimendan (12 mu g/kg) diluted in 10 mL 0.9% NaCl was administered intraperitoneally to group 2. Animals of both groups were sacrificed after 3 days and their testes were harvested for the determination of changes in tissue oxidant/antioxidant status and trace element levels. Tissue malondialdehyde (MDA) was significantly lower in the levosimendan group (P < 0.001) than in the untreated control group and superoxide dismutase and glutathione peroxidase (GSH-Px) levels were significantly higher in the levosimendan group (P < 0.001). Carbonic anhydrase, catalase and GSH levels were not significantly different from controls. Mg and Zn levels of testes were significantly higher (P < 0.001) and Co, Pb, Cd, Mn, and Cu were significantly lower (P < 0.001) in group 2 compared to group 1. Fe levels were similar for the two groups (P = 0.94). These results suggest that 3-day exposure to levosimendan induced a significant decrease in tissue MDA level, which is a lipid peroxidation product and an indicator of oxidative stress, and a significant increase in the activity of an important number of the enzymes that protect against oxidative stress in rat testes.Publication Metadata only Oxidative Stress, Serum Mineral and Trace Element Levels in Patients with Multiple Sclerosis with or without Restless Legs Syndrome(2024-01-01) Akçin Ş.; Gürsoy A. E.; SELEK Ş.; ÇİMEN Y. A.; KÖKTAŞOĞLU F.; MERAL İ.; ÜSTÜNOVA S.; GÜRSOY, AZIZE ESRA; SELEK, ŞAHABETTİN; ÇİMEN, YASİN ALİ; KÖKTAŞOĞLU, FATMANUR; MERAL, İSMAİL; ÜSTÜNOVA, SAVAŞMultiple sclerosis (MS) is a central nervous system disease characterized by inflammation, axonal demyelination and multifocal plaques. Sleep problems due to restless legs syndrome (RLS) are frequently encountered in MS patients. Changes in oxidative stress level and liver enzyme activity and deterioration of trace element homeostasis are observed in MS and RLS patients. This study was conducted to determine serum oxidative stress parameters and trace element levels in MS patients with and without RLS. Thirty healthy individuals (control), 30 MS patients without RLS (MS group) and 30 MS patients with RLS (MS+RLS group) were included in the study. Serum oxidative stress parameters (total antioxidant and oxidant capacities, myeloperoxidase and catalase activities), some liver enzymes (malate dehydrogenase and isocitrate dehydrogenase) activities, blood trace element (copper, zinc and iron) and mineral (calcium, chlorine, magnesium, sodium, potassium) levels were measured. There was no statistically significant difference between the groups in terms of oxidative stress parameters and liver enzymes. Serum chlorine, potassium and sodium levels were higher in the MS+RLS group compared to the controls (p<0.001, p<0.01, p<0.001, respectively), and the zinc level was lower than the control group (p<0.05). Sodium and chlorine levels were higher in the MS+RLS group than in the MS group (p<0.01, p<0.05, respectively). Based on these results, varying trace element levels may have value for early prediction of RLS in MS. In studies with larger sample sizes, changing element and liver enzyme activities in the context of oxidative stress may provide clearer information about the diagnosis of RLS.