Person: MERAL, İSMAİL
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Publication Metadata only Effects of Angiotensin IV on Learning-Memory and Hippocampal Oxidative Stress in Diabetic Rats(2019-12-01T00:00:00Z) KILIÇ, Aysu; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; Bulut, Huri; MERAL, İSMAİL; Sahin, Emine Gulderen; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; BULUT, HURI; MERAL, İSMAİLPublication Metadata only Role of Angiotensin TYpe I and II receptor Blockade in Ischemia/Reperfusion Injury of Isolated Rat Heart(2017-05-04) Kılıç, AYSU; ÜSTÜNOVA, SAVAŞ; Usta, Cansu; BULUT, HURİ; ÜYÜKLÜ, MEHMET; Demirci-Tansel, Cihan; MERAL, İSMAİL; Artumak, Elif; Gurevin-Gürel, Ebru; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; BULUT, HURI; ÜYÜKLÜ, MEHMET; MERAL, İSMAİLPublication Metadata only Sulodexide protected the heart against ischemia/reperfusion injury by reducing oxidative stress, inflammation, and apoptosis in the isolated rat heart(2022-11-17) ÜSTÜNOVA S.; AKSOY R.; BULUT H.; KILIÇ A.; MERAL İ.; RABUŞ M. B.; BOZKURT A. K.; KÖKSAL C.; ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSU; MERAL, İSMAİL; KÖKSAL, CENGİZPublication Open Access Angiotensin IV improves spatial memory in streptozotocin-induced diabetic rats by reducing oxidative stress and altering BDNF levels(2021-01-01T00:00:00Z) KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; Bulut, Huri; MERAL, İSMAİL; Sahin, Gulderen; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; MERAL, İSMAİLIn this study, we investigated the protective effects of angiotensin IV (Mg IV) on cognitive function in streptozotocin (STZ)-induced diabetic rats. Male Wistar albino rats, were randomly divided into four groups; control (C), diabetes (Dia, 60 mg/kg, STZ, i.p.), Mg IV (5 mu g/kg, s.c.) and Dia+Ang W. The passive avoidance and Morris water maze (MWM) tests were used to evaluate learning and memory performance. Behavioral tests were carried out between 21 and 30 days after the initial Ang IV injection. Hippocampi were dissected and retained for biochemical and Western blot analysis. The Dia group exhibited the poorest behavioral results, while the Dia+Ang W group performed highest on the MWM task. Superoxide dismutase, glutathione peroxidase, and malondialdehyde levels increased significantly in the Dia group compared to Dia+Ang IV. Brain-derived neurotrophic factor (BDNF) and N-methyl-D-aspartate levels were significantly elevated, while levels of GABA(A) significantly decreased, in the Dia+Ang IV group compared to the Dia group. These findings suggest that peripheral administration of Ang IV ameliorated spatial memory in diabetic rats by decreasing hippocampal oxidative stress and BDNF levels.Publication Metadata only Effect of Thymoquinone on Ischemia/Reperfusion Injury in Isolated Hearts of Streptozotocin-Induced Diabetic Rats(2019-12-01T00:00:00Z) ÜSTÜNOVA, SAVAŞ; KILIÇ, Aysu; Bulut, Hun; MERAL, İSMAİL; Alican, Inci; ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSU; MERAL, İSMAİLPublication Metadata only Impaired memory by hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic fields is ameliorated by thymoquinone(2022-03-01T00:00:00Z) ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSU; Bulut, Huri; Gurel-Gurevin, Ebru; ERİŞ, ALİ HİKMET; MERAL, İSMAİL; ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSU; ERİŞ, ALİ HİKMET; MERAL, İSMAİLThe protective effects of thymoquinone on learning and memory abilities and on hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic field radiation at s strength of 6.0 +/- 0.5 V/m for 1 h on each of 15 days was studied. Thymoquinone-treatment (10 mg/kg/day) of radiation-exposed rats resulted in better performance than that of radiation-exposed rats not receiving thymoquinone. Electromagnetic field-exposure led to increased hippocampal superoxide dismutase, glutathione peroxidase, and malondialdehyde levels and to lowered brain-derived neurotrophic factor level; thymoquinone treatment ameliorated all four parameters. Also, in the electromagnetic field-exposed group, N-methyl-D-aspartate receptor expression decreased, and gamma-aminobutyric-acid alpha receptor expression increased, which was reversed by thymoquinone treatment. In conclusion, treatment with the thymoquinone ameliorated the impact of the exposure to EMF and provided a hint on the mechanism involving oxidative stress.Publication Metadata only Angiotensin IV’ün Diyabetik Sıçanlarda Öğrenme-Bellek ve Hipokampal Oksidatif Stres Üzerine Etkisi(2019-11-03) Kılıç, Aysu; Üstünova, Savaş; Elibol, Birsen; Bulut, Huri; Meral, İsmail; Şahin, Emine Gülderen; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; MERAL, İSMAİLPublication Open Access A low direct electrical signal attenuates oxidative stress and inflammation in septic rats(2021-09-01T00:00:00Z) Üstünova, Savaş; Hacıosmanoğlu, Ebru; Bulut, Huri; Kılıç, Aysu; Hekimoğlu, Emine Rümeysa; Tunc, Serkan; Kaygusuz, İrem; Tunc, Sevil; Tunc, Gulcin Beyza; Meral, Ismail; ÜSTÜNOVA, SAVAŞ; HACIOSMANOĞLU, EBRU; ELİBOL, BİRSEN; KILIÇ, AYSU; HEKİMOĞLU, EMİNE RÜMEYSA; MERAL, İSMAİLElectrical stimulation is proposed to exert an antimicrobial effect according to studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. Twenty-eight male Wistar albino rats were divided into 4 groups: healthy control (C), electrified healthy (E), sepsis (S), and electrified sepsis (SE) groups. Staphylococcus aureus (1 x 109 colonies) in 1 ml of medium was intraperitoneally injected into rats to produce a sepsis model. The rats in the E and SE groups were exposed to a low direct electrical signal (300 Hz and 2.5 volts) for 40 min and 1 and 6 h after bacterial infection. Immediately after the second electrical signal application, blood and tissue samples of the heart, lung, and liver were collected. An antibacterial effect of a low direct electrical signal was observed in the blood of rats. The effects of electrical signals on ameliorating changes in the histological structure of tissues, blood pH, gases, viscosity and cell count, activities of some important enzymes, oxidative stress parameters, inflammation and tissue apoptosis were observed in the SE group compared to the S group. Low direct electrical signal application exerts antibacterial, antioxidant, anti-inflammatory and antiapoptotic effects on septic rats due to the induction of electrolysis in body fluids without producing any tissue damage.Publication Metadata only Serum Electrolyte Values and Blood Oxidative Stress Parameters in Patients with Focal and Generalized Epilepsy(2023-02-01) Sarı G.; Kılıç A.; Uslu F.; Selek Ş.; Üstünova S.; Meral İ.; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; MERAL, İSMAİLPublication Metadata only Effects of Nigella sativa on Plasma Oxidative Stress, and Some Apoptotic Protein Markers in Cerebrum and Hippocampus in Pentylenetetrazol-Induced Kindling Rats(2020-12-01T00:00:00Z) Üstünova, Savaş; Meral, İsmail; Koçyiğit, Abdürrahim; Kılıç, Aysu; Zeybek, Öykü; Meydan, Sedat; ÜSTÜNOVA, SAVAŞ; MERAL, İSMAİL; KOÇYİĞİT, ABDÜRRAHİM; KILIÇ, AYSU; MEYDAN, SEDAT