Person: MERAL, İSMAİL
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Publication Metadata only Effects of Angiotensin IV on Learning-Memory and Hippocampal Oxidative Stress in Diabetic Rats(2019-12-01T00:00:00Z) KILIÇ, Aysu; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; Bulut, Huri; MERAL, İSMAİL; Sahin, Emine Gulderen; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; BULUT, HURI; MERAL, İSMAİLPublication Metadata only Impaired memory by hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic fields is ameliorated by thymoquinone(2022-03-01T00:00:00Z) ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSU; Bulut, Huri; Gurel-Gurevin, Ebru; ERİŞ, ALİ HİKMET; MERAL, İSMAİL; ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSU; ERİŞ, ALİ HİKMET; MERAL, İSMAİLThe protective effects of thymoquinone on learning and memory abilities and on hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic field radiation at s strength of 6.0 +/- 0.5 V/m for 1 h on each of 15 days was studied. Thymoquinone-treatment (10 mg/kg/day) of radiation-exposed rats resulted in better performance than that of radiation-exposed rats not receiving thymoquinone. Electromagnetic field-exposure led to increased hippocampal superoxide dismutase, glutathione peroxidase, and malondialdehyde levels and to lowered brain-derived neurotrophic factor level; thymoquinone treatment ameliorated all four parameters. Also, in the electromagnetic field-exposed group, N-methyl-D-aspartate receptor expression decreased, and gamma-aminobutyric-acid alpha receptor expression increased, which was reversed by thymoquinone treatment. In conclusion, treatment with the thymoquinone ameliorated the impact of the exposure to EMF and provided a hint on the mechanism involving oxidative stress.Publication Metadata only Angiotensin IV’ün Diyabetik Sıçanlarda Öğrenme-Bellek ve Hipokampal Oksidatif Stres Üzerine Etkisi(2019-11-03) Kılıç, Aysu; Üstünova, Savaş; Elibol, Birsen; Bulut, Huri; Meral, İsmail; Şahin, Emine Gülderen; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; MERAL, İSMAİLPublication Metadata only Effects of combined administration of doxorubicin and chloroquine on lung pathology in mice with solid Ehrlich ascites carcinoma(2022-03-01T00:00:00Z) Utkusavas, Ayfer; Gurevin, Ebru Gurel; YILMAZER, NADİM; ÜVEZ, AYÇA; Oztay, Fusun; Bulut, Huri; ÜSTÜNOVA, SAVAŞ; ESENER, OSMAN BEHZAT BURAK; SÖNMEZ, KIVILCIM; Kutucu, Deniz Erol; MERAL, İSMAİL; Dimas, Konstantinos; ARMUTAK, Elif İlkay; ÜSTÜNOVA, SAVAŞ; MERAL, İSMAİLCombined use of a chemotherapeutic agent and an autophagy inhibitor is a novel cancer treatment strategy. We investigated the effects of chloroquine (CQ) on lung pathology caused by both solid Ehrlich ascites carcinoma (EAC) and doxorubicin (DXR). A control group and eight experimental groups of adult female mice were inoculated subcutaneously with 2.5 x 10(6) EAC cells. DXR (1.5 mg/kg and 3 mg/kg) and CQ (25 mg/kg and 50 mg/kg) alone or in combination were injected intraperitoneally on days 2, 7 and 12 following inoculation with EAC cells. Lung tissue samples were examined using immunohistochemistry (IHC) for endothelial (eNOS), inducible nitric oxide synthase (iNOS) and neutrophil gelatinase-associated lipocalin (NGAL). Serum catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) and malondialdehyde (MDA) levels were measured using ELISA. We found decreased levels of iNOS and eNOS in the groups that received 1.5 mg/kg DXR alone and in combination with 25 mg/kg and 50 mg/kg CQ. Combined administration of DXR and CQ partially prevented disruption of alveolar structure. Levels of antioxidant enzymes and MDA were lower in all treated groups; the greatest reduction was observed in mice that received the combination of 25 mg/kg CQ + 1.5 mg/kg DXR. Levels of NGAL were elevated in all treated groups. We found that CQ ameliorated both EAC and DOX induced lung pathology in female mice with solid EAC by reducing oxidative stress.Publication Metadata only Timokinonun streptozotosin ile diyabet oluşturulan sıçanların izole kalplerinde iskemi/reperfüzyon hasarı üzerine etkisi(2019-12-02T00:00:00Z) Üstünova, Savaş; Kılıç, Aysu; Bulut, Huri; Meral, İsmail; Alican, Yaşar İnci; ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSU; MERAL, İSMAİL