Person: KUMAŞ, MELTEM
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Publication Metadata only An observation of haversian systems in Stellagama stellio (Linnaeus, 1758) (Squamata: Sauria: Agamidae) in Barla/Isparta, Turkey(2015-01-01T00:00:00Z) Kumas, MELTEM; AYAZ, DİNÇER; KUMAŞ, MELTEMIn this study, we observed haversian systems on the endosteal surface of the femur bone of one male individual of Roughtail Rock Agama, Stellagama stellio, which was collected from Barla/Isparta province of Turkey. It was observed that the haversian canal was located on the center of the haversian systems or secondary osteons, and it was surrounded by concentric lamellae. All lamellae were separated from each other by a cement line that stained darker than other constituents. Volkmann-s canals were not observed between haversian canals, and other concentric lamellae were not encountered between periosteum and haversian systems. These results indicate that remodeling can be partly seen in this species. Our study is important in terms of being the first record to demonstrate haversian systems on the femur bone of S. stellio.Publication Open Access Protective Effects of Curcumin on Cadmium-Induced Renal Injury in Young and Aged Rats(2016-12-01) Kumas, MELTEM; Esrefoglu, MUKADDES; Bayindir, NİHAN; Iraz, Meryem; Ayhan, Siddika; Meydan, SEDAT; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; BAYINDIR, NİHAN; MEYDAN, SEDATObjective: We aimed to investigate the protective effects of curcumin (Cr) against cadmium (Cd) toxicity on the kidneys of both young and aged rats. Methods: Forty-eight young and aged female Spraque–Dawley rats were divided into control, Cd, Cr, and Cd+Cr groups. We investigated kidney damage using a histopathological scoring system and measured total antioxidant status (TAS) and total oxidant status (TOS) and interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) levels. Results: Kidney tissues of Cd groups showed acute histopathological alterations. Cr improved Cd-induced histopathological changes (p<0.05). The highest mean TAS was recorded in both the Cr groups. The highest mean TOS was recorded only in the aged Cd group. Cr decreased IL-6 levels in both the Cd+Cr groups (p<0.05). PCT levels in the Cd groups were higher than those in the control groups. Significance was detected only between the young Cd and control groups (p<0.05). PCT levels were reduced in both the Cd+Cr groups (p<0.05). CRP levels in the aged Cd group were higher than those in the other groups (p<0.05). Cr reduced CRP levels only in the aged Cd+Cr group (p<0.05). Conclusion: Our results suggest that Cr prevents Cd-induced renal oxidative damage in both young and aged rats.Publication Metadata only Investigation of the histological development of the frontal ganglion in Locusta migratoria L. 1758 (Orthoptera, Acrididae)(2012-01-01T00:00:00Z) Kumas, MELTEM; Karakisi, Hatice; KUMAŞ, MELTEMThe frontal ganglion plays a critical role in insect feeding and molting-related behaviors. It is present in all insect orders at all developmental stages. In this study, the histological development of the frontal ganglion of Locusta migratoria, the African migratory locust, was investigated. Ganglia were dissected at 3 distinct developmental stages and their histological structure was evaluated at the light microscope level. The development of the cells generating the ganglion in the first and fifth nymphal stages and in adults was determined using the variance analysis method. Total width and length of the ganglion cells as well as width and length of the nucleus were measured. A significant expansion of the cell and nucleus diameter was observed during development from the youngest stage toward adulthood.Publication Metadata only Protective effects of silymarin against isotretinoin induced liver and kidney injury in mice(2018-03-01) Kumas, MELTEM; Esrefoglu, MUKADDES; Guler, ERAY METİN; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; GÜLER, ERAY METİNIsotretinoin (ISR), the common therapeuticagent for acne vulgaris, when used long term, leads to various side effects viz., oxidative toxicity, renal and hepatic dysfunction, depression, congenital abnormalities, aortic art defects, microcephaly, etc. Here, we explored the effects of silymarin (SLY), a flavonolignan from the seeds of the milk thistle Silybum marianum (L.) which has potential to protect the liver against chemical and environmental toxins and increase proliferation rate of tubule cells, against ISR induced liver and kidney injury. Thirty-two male Balb/c mice (3 months of age) were divided into four groups: control, isotretinoin (ISR, 40 mg/kg/day), silymarin (SLY, 200 mg/kg/day), and ISR+SLY group. We investigated liver and kidney injury by histopathological scoring system, and apoptotic cells labelled by TUNEL method. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured in serum samples biochemically. ALT and AST levels were increased in ISR group (P = 0.025, P = 0.003, respectively). SLY decreased those levels in ISR+SLY group (P = 0.002, P = 0.013, respectively). Liver tissues of ISR group showed interstitial edema and necrosis, alteration in shape and size of nuclei, mononuclear and kuppfer cell infiltration. Kidney tissues of ISR group showed tubular degeneration, necrosis, glomerular collapse, mononuclear cell infiltration, and hemorrhage. SLY improved those histopathological changes and suppressed apoptotic cell death. We suggest that silymarin might be beneficial to some extent by preventing the side effects induced by chronic ISR therapy in patients with acne vulgaris.Publication Metadata only Neuroprotective effect of ischemic preconditioning via modulating the expression of adropin and oxidative markers against transient cerebral ischemia in diabetic rats(2016-05-01) ALTINTAS, OZGE; Kumas, MELTEM; Altintas, M. O.; KUMAŞ, MELTEMIntroduction: Ischemic preconditioning (IPreC) can render the brain more tolerant to a subsequent potential lethal ischemic injury. Hyperglycemia has been shown to increase the size of ischemic stroke and worsen the clinical outcome following a stroke, thus exacerbating oxidative stress. Adropin has a significant association with cardiovascular disease, especially with diabetes. In this study, we aimed to evaluate the role of the IPreC due to modulating the expression of adropin and oxidative damage markers against stroke by induced transient middle cerebral artery occlusion (MCAo) in streptozotocin (STZ)-induced diabetic rats.Publication Metadata only Neuroprotective effect of ischemic preconditioning via modulating the expression of cerebral miRNAs against transient cerebral ischemia in diabetic rats(2016-01-01) ALTINTAS, Ozge; Altintas, Mehmet Ozgen; Kumas, MELTEM; Asil, TALİP; KUMAŞ, MELTEM; ASİL, TALIPObjectives: In this study, we aimed to evaluate the effect of the Ischemic preconditioning (IPreC) on the expression profile of cerebral miRNAs against stroke by induced transient middle cerebral artery occlusion (MCAo) in diabetic rats.Publication Open Access Protective Effects of Silymarin against Cardiac Tissue Injury Caused By a High-dose Administration of Isotretinoin in Mice(2016-08-01) Kumas, MELTEM; Esrefoglu, MUKADDES; Ozer, Omer Faruk; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; ÖZER, ÖMER FARUKObjective: We aimed to histopathologically and biochemically investigate the protective effects of silymarin (SLY) against cardiac injury induced by a high-dose isotretinoin (ISR) administration. Methods: Thirty-two male Balb/c mice were divided into four groups: control, ISR, SLY, and co-treated (ISR+SLY) groups. For the histopathological analysis, all sections were stained with hematoxylin eosin and Masson's trichrome. The TUNEL detection kit was used for the detection of cardiac apoptosis. The oxidative stress markers, which included catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GSH-Px), and glutathione reductase (GSH-red), and the glutathione S-transferase (GST) and lipid peroxidation markers, which included erythrocyte malondialdehyde (E-MDA) and plasma malondialdehyde (P-MDA), were biochemically determined. All statistical analyses were conducted with SPSS 18.0 (IBM, New York, USA) and GraphPad Prism Version 6.01 (USA). The Student's t-test was applied to the parametric data for comprising among groups. The P-significance degree was evaluated as 95%. Results: Severe histopathological alterations were observed in cardiac tissue. The ISR group showed hemorrhage, necrosis, edema, and congestion in cardiac tissues. SLY did not improve ISR-induced histopathological changes (p>0.05). The highest number of apoptotic cells was detected in the ISR group. In the ISR+SLY group, SLY treatment reduced apoptosis (p <= 0.05). Antioxidant enzyme activities (CAT, SOD, GSH-Px, GSH-Red, GSH, GST) were induced in ISR+SLY group (p=0.015, p>0.05, p=0.002, p=0.002, p=0,018, p=0.002; respectively). E-MDA (p=0.003) and P-MDA (p=0.005) levels significantly increased in the ISR group and decreased in the SLY group. Conclusion: SLY increased antioxidant enzyme activities, prevented lipid peroxidation, and decreased apoptosis. SLY was found to be an antioxidant against ISR-induced cardiac oxidative damage.