Person: KUMAŞ, MELTEM
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Publication Diyabetik sıçanlarda malign serebral iskemi ve iskemik ön koşullanmanın testis dokusu üzerine uzak doku etkilerinin histopatolojik açıdan incelenmesi(2015-12-03) KUMAŞ, MELTEM; ALTINTAS, OZGE; EŞREFOĞLU, MUKADDES; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDESPublication Diabetik sıçanlarda malign serebral iskemi ve iskemik ön koşullanmanın epigenetik rolünün araştırılması(2015-12-03) ALTINTAS, OZGE; KUMAŞ, MELTEM; ALTINTAS, MEHMET OZGEN; ASİL, TALİP; KUMAŞ, MELTEM; ASİL, TALIPPublication Protective effects of silymarin against kidney injury caused by high dose administration of isotretinoin in mice.(2015-09-24) Kumaş, MELTEM; EŞREFOĞLU, MUKADDES; Kesgin, S; Özer, OF; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; ÖZER, ÖMER FARUKPublication Relationship between regular exercise-induced cardiac hypertrophy and micro RNA(2017-09-30) PALA, MUKADDES; ALTAN, MEHMET; SÖNMEZ, OSMAN FUAT; MENGİ, MURAT; Dinçer, Şensu; AKBAŞ, FAHRİ; YILDIZ, MUSTAFA; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; METİN, GÖKHAN; AKBAŞ, FAHRİ; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDESPublication A skeletochronological study of age, growth and longevity in two freshwater turtles, Emys orbicularis and Mauremys rivulata from Mediterranean Turkey (Reptilia: Testudines).(2016-02-01) Ayaz, Dinçer; Çiçek, Kerim; KUMAŞ, MELTEM; Tok, Cemal Varol; KUMAŞ, MELTEMWe estimated growth parameters of Emys orbicularis and Mauremys rivulata in Mediterranean Turkey with the skeletochronological method, using specimens drowned in fyke nets. In adult E. orbicularis, the median age was 8 years in males and 10 years in females. The median age of adult M. rivulata was 10 years for both sexes. Both species reach sexual maturity at an age of 5-7 years. No difference was found in age composition between the sexes.Publication Skin Pigmentation of Stellagama stellio (L. 1758) (Reptilia: Agamidae) Depends on Climate Conditions and Altitude(2017-09-01) Çiçek, Kerim; KUMAŞ, MELTEM; Ayaz, Dinçer; KUMAŞ, MELTEMWe studied skin pigmentation characteristics of the starred agama, Stellagama stellio, at different altitudes and climate conditions from Anatolia, Turkey. The epidermis was composed of stratum corneum and stratum basale, while the dermis occupied a much larger area. Melanophores were only found in the dermis and melanin pigments exhibited different distribution patterns in cells. Our results indicated that the skin pigmentation of S. stellio varied among populations depending on the altitude and climatic conditions. At higher altitudes, the melanophores in dorsal skin were larger and its melanin pigments aggregated in melanophores. The aggregation of the melanin pigments indicated the skin had lighter colour. The melanin pigments tended to be dispersed at lower altitudes. The skin of populations inhabiting hot climates and lower altitudes was more pigmented, while populations from steppe and higher altitudes exhibit lower pigmentation when comparing melanophores areas.Publication Berberine Attenuates Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage Via Modulating AMPK/Rho Pathway(2020-01-01T00:00:00Z) Kadirhan, Ozge Altintas; Kumas, Meltem; Karatas, Ersin; Mutlu, Hasan Serdar; KOÇYİĞİT, ABDÜRRAHİM; Asil, Talip; KUMAŞ, MELTEM; KOÇYİĞİT, ABDÜRRAHİM; ASİL, TALIPPurpose: Our goal is to clarify the effectiveness of berberine (BBR) on cerebral vasospasm induced by subarachnoid hemorrhage.Publication Protective Effects of Silymarin against Cardiac Tissue Injury Caused By a High-dose Administration of Isotretinoin in Mice(2016-08-01) Kumas, MELTEM; Esrefoglu, MUKADDES; Ozer, Omer Faruk; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; ÖZER, ÖMER FARUKObjective: We aimed to histopathologically and biochemically investigate the protective effects of silymarin (SLY) against cardiac injury induced by a high-dose isotretinoin (ISR) administration. Methods: Thirty-two male Balb/c mice were divided into four groups: control, ISR, SLY, and co-treated (ISR+SLY) groups. For the histopathological analysis, all sections were stained with hematoxylin eosin and Masson's trichrome. The TUNEL detection kit was used for the detection of cardiac apoptosis. The oxidative stress markers, which included catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GSH-Px), and glutathione reductase (GSH-red), and the glutathione S-transferase (GST) and lipid peroxidation markers, which included erythrocyte malondialdehyde (E-MDA) and plasma malondialdehyde (P-MDA), were biochemically determined. All statistical analyses were conducted with SPSS 18.0 (IBM, New York, USA) and GraphPad Prism Version 6.01 (USA). The Student's t-test was applied to the parametric data for comprising among groups. The P-significance degree was evaluated as 95%. Results: Severe histopathological alterations were observed in cardiac tissue. The ISR group showed hemorrhage, necrosis, edema, and congestion in cardiac tissues. SLY did not improve ISR-induced histopathological changes (p>0.05). The highest number of apoptotic cells was detected in the ISR group. In the ISR+SLY group, SLY treatment reduced apoptosis (p <= 0.05). Antioxidant enzyme activities (CAT, SOD, GSH-Px, GSH-Red, GSH, GST) were induced in ISR+SLY group (p=0.015, p>0.05, p=0.002, p=0.002, p=0,018, p=0.002; respectively). E-MDA (p=0.003) and P-MDA (p=0.005) levels significantly increased in the ISR group and decreased in the SLY group. Conclusion: SLY increased antioxidant enzyme activities, prevented lipid peroxidation, and decreased apoptosis. SLY was found to be an antioxidant against ISR-induced cardiac oxidative damage.Publication Ratlarda Kurkuminin Kadmiyum ile İndüklenen Karaciğer Apopitozu Üzerine Koruyucu Etkisi(2016-12-01) BAYINDIR, NİHAN; EŞREFOĞLU, MUKADDES; KUMAŞ, MELTEM; Iraz, Meryem; Ayhan, Sıddıka; Kılıç, Elif; BAYINDIR, NİHAN; EŞREFOĞLU, MUKADDES; KUMAŞ, MELTEMPublication Investigation of dose-dependent effects of berberine against renal ischemia/reperfusion injury in experimental diabetic rats(2019-01-01) Kanbay, Songül; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; Karataş, Ersin; Duymaç, Nurcihan; ERGÜN, İLYAS SAMET; ÜYÜKLÜ, MEHMET; KOÇYİĞİT, ABDÜRRAHİM; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; ERGÜN, İLYAS SAMET; ÜYÜKLÜ, MEHMET; KOÇYİĞİT, ABDÜRRAHİMBackground: Ischemia-reperfusion injury causes various severe morphological and functional changes in diabetic patients. To date, numerous antidiabetic and antioxidant agents have been used for treatment of the disease-related changes. Objectives: We aimed to examine effective therapeutic doses or doses of berberine against renal ischemia/reperfusion injury (IRI) in a streptozotocin (STZ)-induced diabetic rat model by histopathological and biochemical analysis. Methods: Thirty male Sprague Dawley rats were treated with STZ injection for the development of diabetes, and divided into the following groups: STZ-induced diabetic group (STZ); IRI-induced diabetic group (STZ+IRI); 50mg/kg berberine (BRB) treated diabetic group after inducing IRI (STZ+IRI+BRB1); 100mg/kg BRB treated diabetic group after IRI (STZ+IRI+BRB2); 150mg/kg BRB treated diabetic group after IRI (STZ+IRI+BRB3). Bilateral renal ischemia model was applied for 45min, then reperfusion was allowed for 14 days in STZ-induced diabetic rats. Renal injury was detected histopathologically. Blood urea nitrogen (BUN), creatinine and lactate dehydrogenase (LDH) levels were measured in serum using the ELISA method. Total antioxidant status (TAS) and total oxidant status (TOS) of renal tissue was studied by spectrophotometric assay. Oxidative stress index (OSI) was calculated as TOS-to-TAS ratio. Tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), Na+/K+-ATPase (sodium pump), and Ca2+-ATPase (calcium ATPase) enzyme levels were measured in tissues using the ELISA method. Anti-apoptotic Bax and pro-apoptotic Bcl-2 protein levels were detected by Western blot analysis. All data were evaluated statistically. Results: The highest histopathological score was detected in the STZ+IRI group compared to the other group. BRB administration at the doses of 100mg/kg and 150mg/kg markedly improved renal injury. BUN and creatinine levels significantly increased in the STZ+IRI group compared to the STZ group (p<0.001). 100mg/kg and 150mg/kg BRB administration significantly decreased those levels (p<0.01). The highest TOS and the lowest TAS levels were detected in the STZ+IRI group (p<0.001). IRI markedly aggravated inflammation via increasing levels of TNF-α and CRP (<0.001), and caused apoptosis via inducing Bcl-2 protein, and suppressing Bax protein (p<0.001). BRB administration at the doses of 100mg/kg and 150mg/kg showed anti-oxidant, anti-inflammatory and anti-apoptotic effects (p<0.01). The LDH enzyme, was used as a necrosis marker, was higher in the STZ+IRI group than other groups. BRB administration at all of the doses, resulted in the decline of LDH enzyme level (p<0.001). Ca2+-ATPase and Na+/K+-ATPase enzyme activities decreased in the STZ+IRI group compared to the STZ group (p<0.001), while BRB administration at the doses of 100mg/kg and 150mg/kg significantly increased those of enzyme activities, respectively (p<0.05). Conclusion: Ischemia with diabetes caused severe histopathological and biochemical damage in renal tissue. The high doses of berberine markedly improved histopathological findings, regulated kidney function via decreasing BUN and creatinine levels, and rearranged intercellular ion concentration via increasing Na+/K+-ATPase and Ca2+- ATPase levels. Berberine showed anti-oxidant, anti-apoptotic, and anti-inflammatory effects. According to these data, we suggest that berberine at the doses of 100 and 150mg may be used as a potential therapeutic agent to prevent renal ischemic injury.
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