Person: KUMAŞ, MELTEM
Now showing 1 - 10 of 30
- PublicationOpen AccessProtective Effect of Curcumin on Cadmium-Induced Liver Apoptosis in Rats(2016-12-01T00:00:00Z) Bayindir, Nihan; EŞREFOĞLU, MUKADDES; Kumas, Meltem; Iraz, Meryem; Kesgin, Siddika; Kilic, Elif; BAYINDIR, NİHAN; EŞREFOĞLU, MUKADDES; KUMAŞ, MELTEMObjective: Cadmium (CD), which is used for many industrial purposes, is a toxic agent. CD accumulates in the liver; therefore, exposure to toxic doses of Cd results in hepatic damage. Studies in rats have shown that CD induces apoptosis in hepatocytes. Curcumin is a natural compound isolated from Curcuma longa. It has a powerful anti-inflammatory affect and scavenges reactive oxygen radicals. Additionally, it has been shown to have an anti-apoptotic effect in a dose-dependent manner. The aim of the present study was to evaluate the effects of therapeutic doses of curcumin on Cd-induced hepatic apoptosis as well as hepatic biochemical and inflammatory changes in Sprague-Dawley rats.
- PublicationMetadata onlyComparative Eberth-Katschenko Layer Histomorphology of Four Anurans (Bufo bufo, Bufotes variabilis, Pelophylax bedriagae, Hyla savignyi)(2017-09-15) Çiçek, Kerim; Ayaz, Dinçer; Akat, Esra; Yenmiş, Melodi; KUMAŞ, MELTEM
- PublicationMetadata onlyBiochemical, Histopathologic, and Genotoxic Effects of Ethanol Extract of Salvia hypargeia (Fisch. & Mey.) on Incisional and Excisional Wounded Diabetic Rats(2019-03-01) Gökalp Özkorkmaz, Ebru; Güzel, Sevda; Uzun, Coşar; Yıldırım , Zuhal; Çelik , Ayla; Çamlıca, Yusuf; yumrutaş, önder; Güler , Gizem; Erdal, Nurten; Taşdelen , Bahar; Çelikcan, Havva Didem; Kahraman , Ahmet; KUMAŞ, MELTEM
- PublicationMetadata onlySubaraknoid kanama modeli oluşturulan sıçanlarda berberin maddesinin serebral vazospasm üzerine nöroprotektif etkisinin gösterilmesi(2016-12-01) ALTINTAS, OZGE; KUMAŞ, MELTEM; KARATAŞ, Ersin; KOÇYİĞİT, ABDÜRRAHİM; ASİL, TALİP; KUMAŞ, MELTEM; KOÇYİĞİT, ABDÜRRAHİM; ASİL, TALIP
- PublicationMetadata onlyNeuroprotective effect of ischemic preconditioning via modulating the expression of cerebral miRNAs against transient cerebral ischemia in diabetic rats(2016-01-01) ALTINTAS, Ozge; Altintas, Mehmet Ozgen; Kumas, MELTEM; Asil, TALİP; KUMAŞ, MELTEM; ASİL, TALIPObjectives: In this study, we aimed to evaluate the effect of the Ischemic preconditioning (IPreC) on the expression profile of cerebral miRNAs against stroke by induced transient middle cerebral artery occlusion (MCAo) in diabetic rats.
- PublicationMetadata onlyAge determination and long bone histology in Stellagama stellio (Linnaeus, 1758) (Squamata: Sauria: Agamidae) populations in Turkey(2014-05-01T00:00:00Z) KUMAŞ, Meltem; AYAZ, DİNÇER; KUMAŞ, MELTEMIn this study, the age structures of the four populations of Roughtail Rock Agama, Stellagama stellio distributed in Turkey were determined and their long bone development was examined from a histological perspective. The ages of some 218individuals (32 juveniles, 86 male male, 100 female female) captured from the Mediterranean, Transitional Mediterranean, Aegean, and Central Anatolia Regions were computed with the method of skeletochronology, and the correlation between age and the SVL (the snout-vent length) was compared. The mean SVL was greater in males than in females, and this difference was found statistically significant in all populations except for the Central Anatolian population. The mean ages for male and female individuals were calculated as 3.44 +/- 1.26 and 3.18 +/- 1.18 years in the Mediterranean population, as 4.65 +/- 1.25 and 3.69 +/- 1.31 years in the Transitional Mediterranean population, as 4.05 +/- 1.32 and 3.36 +/- 1.46 years in the Aegean population, and as 4.20 +/- 1.87 and 3.60 +/- 2.01 years in the Central Anatolian population, respectively. The oldest individuals were encountered in the Central Anatolian populations, and the maximum age detected for both sexes was 7 years. It was determined that the age at maturity was 3 in all the populations under examination and that there was not any difference in age at maturity either among the populations or between sexes. There was a significant positive correlation between age and the SVL. The impacts of environmental factors on age structures were examined, and altitude, latitude and climate were found effective on longevity. Histologically, the primary bone, which developed in the embryonic period, was preserved throughout the life of a species even in the oldest individual. Neither secondary bone development nor formation of lamellar systems was encountered. It was seen that intramembranous and endochondral ossification mechanisms played a joint role in long bone development.
- PublicationMetadata onlySkin Pigmentation of Stellagama stellio (L. 1758) (Reptilia: Agamidae) Depends on Climate Conditions and Altitude(2017-09-01) Çiçek, Kerim; KUMAŞ, MELTEM; Ayaz, Dinçer; KUMAŞ, MELTEMWe studied skin pigmentation characteristics of the starred agama, Stellagama stellio, at different altitudes and climate conditions from Anatolia, Turkey. The epidermis was composed of stratum corneum and stratum basale, while the dermis occupied a much larger area. Melanophores were only found in the dermis and melanin pigments exhibited different distribution patterns in cells. Our results indicated that the skin pigmentation of S. stellio varied among populations depending on the altitude and climatic conditions. At higher altitudes, the melanophores in dorsal skin were larger and its melanin pigments aggregated in melanophores. The aggregation of the melanin pigments indicated the skin had lighter colour. The melanin pigments tended to be dispersed at lower altitudes. The skin of populations inhabiting hot climates and lower altitudes was more pigmented, while populations from steppe and higher altitudes exhibit lower pigmentation when comparing melanophores areas.
- PublicationMetadata onlyProtective effect of ischemic preconditioning on testis injury following transient focal cerebral ischemia in diabetic rats.(2017-06-01) KUMAŞ, MELTEM; Altıntaş, Ozge; EŞREFOĞLU, MUKADDES; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDESOBJECTIVES: We aim to evaluate the effect of ischemic preconditioning (IPreC) on testicular tissue after transient middle cerebral artery occlusion (MCAo) in Streptozotocin-induced diabetic (STZ) and non-diabetic rats.
- PublicationMetadata onlyRelationship between regular exercise-induced cardiac hypertrophy and micro RNA(2017-09-01) Pala, M.; Altan, M.; Sonmez, O. F.; Mengi, M.; Dincer, S.; AKBAS, FAHRİ; Yildiz, M.; KUMAS, MELTEM; Esrefoglu, MUKADDES; Metin, G.; AKBAŞ, FAHRİ; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES
- PublicationOpen AccessInvestigation of dose-dependent effects of berberine against renal ischemia/reperfusion injury in experimental diabetic rats(2019-01-01) Kanbay, Songül; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; Karataş, Ersin; Duymaç, Nurcihan; ERGÜN, İLYAS SAMET; ÜYÜKLÜ, MEHMET; KOÇYİĞİT, ABDÜRRAHİM; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; ERGÜN, İLYAS SAMET; ÜYÜKLÜ, MEHMET; KOÇYİĞİT, ABDÜRRAHİMBackground: Ischemia-reperfusion injury causes various severe morphological and functional changes in diabetic patients. To date, numerous antidiabetic and antioxidant agents have been used for treatment of the disease-related changes. Objectives: We aimed to examine effective therapeutic doses or doses of berberine against renal ischemia/reperfusion injury (IRI) in a streptozotocin (STZ)-induced diabetic rat model by histopathological and biochemical analysis. Methods: Thirty male Sprague Dawley rats were treated with STZ injection for the development of diabetes, and divided into the following groups: STZ-induced diabetic group (STZ); IRI-induced diabetic group (STZ+IRI); 50mg/kg berberine (BRB) treated diabetic group after inducing IRI (STZ+IRI+BRB1); 100mg/kg BRB treated diabetic group after IRI (STZ+IRI+BRB2); 150mg/kg BRB treated diabetic group after IRI (STZ+IRI+BRB3). Bilateral renal ischemia model was applied for 45min, then reperfusion was allowed for 14 days in STZ-induced diabetic rats. Renal injury was detected histopathologically. Blood urea nitrogen (BUN), creatinine and lactate dehydrogenase (LDH) levels were measured in serum using the ELISA method. Total antioxidant status (TAS) and total oxidant status (TOS) of renal tissue was studied by spectrophotometric assay. Oxidative stress index (OSI) was calculated as TOS-to-TAS ratio. Tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), Na+/K+-ATPase (sodium pump), and Ca2+-ATPase (calcium ATPase) enzyme levels were measured in tissues using the ELISA method. Anti-apoptotic Bax and pro-apoptotic Bcl-2 protein levels were detected by Western blot analysis. All data were evaluated statistically. Results: The highest histopathological score was detected in the STZ+IRI group compared to the other group. BRB administration at the doses of 100mg/kg and 150mg/kg markedly improved renal injury. BUN and creatinine levels significantly increased in the STZ+IRI group compared to the STZ group (p<0.001). 100mg/kg and 150mg/kg BRB administration significantly decreased those levels (p<0.01). The highest TOS and the lowest TAS levels were detected in the STZ+IRI group (p<0.001). IRI markedly aggravated inflammation via increasing levels of TNF-α and CRP (<0.001), and caused apoptosis via inducing Bcl-2 protein, and suppressing Bax protein (p<0.001). BRB administration at the doses of 100mg/kg and 150mg/kg showed anti-oxidant, anti-inflammatory and anti-apoptotic effects (p<0.01). The LDH enzyme, was used as a necrosis marker, was higher in the STZ+IRI group than other groups. BRB administration at all of the doses, resulted in the decline of LDH enzyme level (p<0.001). Ca2+-ATPase and Na+/K+-ATPase enzyme activities decreased in the STZ+IRI group compared to the STZ group (p<0.001), while BRB administration at the doses of 100mg/kg and 150mg/kg significantly increased those of enzyme activities, respectively (p<0.05). Conclusion: Ischemia with diabetes caused severe histopathological and biochemical damage in renal tissue. The high doses of berberine markedly improved histopathological findings, regulated kidney function via decreasing BUN and creatinine levels, and rearranged intercellular ion concentration via increasing Na+/K+-ATPase and Ca2+- ATPase levels. Berberine showed anti-oxidant, anti-apoptotic, and anti-inflammatory effects. According to these data, we suggest that berberine at the doses of 100 and 150mg may be used as a potential therapeutic agent to prevent renal ischemic injury.
- 1 (current)