Person: ÖZÇELİK, SEMRA
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Publication Open Access Comparative Evaluation of Orthostatic Hypotension in Patients with Diabetic Nephropathy.(2021-07-20T00:00:00Z) Aytaş, Gamze; Elçioğlu, Ömer C; Kazancıoğlu, Rümeyza; Gürsu, Meltem; Artan, A Serra; Yabacı, Ayşegül; Soysal, PINAR; Bilgi, Kadir; Özçelik, Semra; KAZANCIOĞLU, RÜMEYZA; ELÇİOĞLU, ÖMER CELAL; GÜRSU, MELTEM; YABACI TAK, AYŞEGÜL; SOYSAL, PINAR; ÖZÇELİK, SEMRAIntroduction: Orthostatic hypotension (OH) affects 5-20% of the population. Our study investigates the presence of OH in diabetic nephropathy (DNP) patients and the factors affecting OH in comparison with nondiabetic chronic kidney disease (NDCKD) patients. Method: Patients presented to the nephrology clinic, and those who consented were included in the study. DNP was defined by kidney biopsy and/or clinical criteria. NDCKD patients of the same sex, age, and eGFR were matched to DNP patients. Demographic parameters and medications were obtained from the records. OH was determined by Mayo clinic criteria. The same researcher used an electronic device to measure blood pressure (BP). All samples were taken and analyzed the same day for biochemical and hematologic parameters and albuminuria. Results: 112 (51 F, 61 M, mean age: 62.56 ± 9.35 years) DNP and 94 (40 F, 54 M, mean age: 62.23 ± 10.08 years) NDCKD patients were included. There was no significant difference between DNP and NDCKD groups in terms of OH prevalence (70.5 vs. 61.7%, p = 0.181). Male patients had significantly higher OH prevalence than female patients (74.7 vs. 60.0%, p = 0.026). There was no significant difference in change in systolic BP between the groups (24.00 [10.00-32.00] mm Hg vs. 24.00 [13.75-30.25] mm Hg, p = 0.797), but the change in diastolic BP was significantly higher in the DNP group (8.00 [2.00-13.00] mm Hg vs. 6.00 [2.00-9.00] mm Hg, p = 0.025). In the DNP group, patients with OH had significantly higher uric acid levels than those without OH (7.18 ± 1.55 vs. 6.36 ± 1.65 mg/dL, p = 0.017). And, 73.7% of patients on calcium channel blockers developed OH (p = 0.015), and OH developed in 80.6% of 36 patients on alpha-blockers (p = 0.049). Conclusion: OH prevalence is very high in CKD, and etiology of CKD does not have a statistically significant effect on the frequency of OH, despite a difference that could be meaningful clinically. Therefore, patients with CKD are checked for OH, with or without concurrent diabetes mellitus. Evaluation of postural BP changes should be a part of nephrology practice.Publication Open Access Medical Education in Epidemic and Disaster Situations(2020-11-01T00:00:00Z) Özçelik, Semra; Küçük, Özlem Su; Çakır, Erkan; Kazancıoğlu, Rümeyza; ÖZÇELİK, SEMRA; SU KÜÇÜK, ÖZLEM; ÇAKIR, ERKAN; KAZANCIOĞLU, RÜMEYZAThere is no standard practice for the sustainability of medical education in epidemics such as Covid-19 and disasters affecting society. Synchronous or asynchronous trainings have been carried out in some of universities and colleges that have distance education technical infrastructure, during the Covid-19 pandemic. If every student has access to information technologies and the skills of the instructors who will prepare and deliver the training increase their ability to use information technologies, there is no problem in the implementation and maintenance of theoretical lessons. During the Covid-19 pandemic, we had to go to distance education, which we had not yet implemented at Bezmialem Vakıf University Faculty of Medicine. During this period, we applied asynchronous and synchronous education models (mixed model) for theoretical lessons. However, the fact that practical and internship applications were carried out by distance education - although videos about skills and practices were shot and uploaded to the system - it was not possible to replace the formal education. Distance education is inevitable for the continuity of education in epidemic and disaster situations. However, after the epidemic and disaster situations have passed, practical and internship practices should be carried out as much as possible in addition to distance education in medical education. In normal times, distance education can only be used to support formal education in medical education. As a result of all these evaluations and experiences we gained in the Covid 19 pandemic, we think that synchronous/synchronous distance education applications will improve over time and contribute to medical education.Publication Open Access Fibromiyalji Sendromu ile Bağırsak Mikrobiyotası Arasındaki İlişkinin Araştırılması(2021-03-01T00:00:00Z) Albayrak, Büşra; Süsgün, Seda; Küçükakkaş, Okan; Akbaş, Fahri; Yabacı, Ayşegül; Özçelik, Semra; SÜSGÜN, SEDA; KÜÇÜKAKKAŞ, OKAN; AKBAŞ, FAHRİ; YABACI TAK, AYŞEGÜL; ÖZÇELİK, SEMRAFibromiyalji sendromu (FMS), yetişkin popülasyonda bildirilen prevalansı %3-10 olan, kronik yaygın ağrının sık görülen formlarından biridir. Tipik ağrının klinik görünümü ve ilişkili somatik ve psikolojik semptomların varlığı tanıya temel oluşturur. FMS sinir sistemi disfonksiyonu ile ilişkilidir ve nörotransmitterler fibromiyalji için onaylanmış bir dizi ilacın hedefi olarak rol oynamaktadır. Bununla birlikte, FMS’de altta yatan mekanizmalar kesin olarak henüz bilinmemekle birlikte birçok hipotez ortaya konmuştur. Fibromiyalji ve irritabl bağırsak sendromu (IBS) arasındaki ilişki göz önüne alındığında, değişen bağırsak mikrobiyomu fibromiyalji ile ilişkili olabilir. Bu çalışmada, FMS tanılı hastalarda sağlıklı kontrollere göre değişen bağırsak mikrobiyom düzeylerinin araştırılması amaçlanmıştır. Mikrobiyom çalışması için FMS tanılı 54 hastadan ve 36 sağlıklı kişiden oluşan kohorttan fekal örnekler toplanmıştır. Kontrol grubunda herhangi bir mental ve/veya fiziksel hastalığı olanlar çalışma dışında bırakılmıştır. FMS’li hasta grubu, -American College of Rheumatology (ACR)- 2010 tanı kriterlerine bağlı kalınarak belirlenmiştir. Fekal örnekler, kullanılana kadar -80°C’de muhafaza edilmiş ve buz üzerinde çözülmüş; her ekstraksiyon için 0.3 g feçes tartılmıştır. DNA izolasyonu, ticari kit ile üreticinin protokolüne uygun olarak gerçekleştirilmiştir. Örnekler, gerçek zamanlı polimeraz zincir yöntemi ile Bacteroidetes, Firmicutes, Enterobacter, Lactobacillus, Streptococcus ve Bifidobacterium’a özgül primerler ile 16S rRNA gen amplifikasyonu yapılarak karşılaştırılmıştır. Sonuçlara göre, hasta grubunda Bacteroidetes ve Bifidobacterium istatistiksel olarak anlamlı bir şekilde artarken (p< 0.05), Firmicutes’in azaldığı saptanmıştır (p< 0.001). Enterobacter, Streptococcus ve Lactobacillus için istatistiksel olarak anlamlı sonuç bulunamamıştır (p> 0.05). Bakteriler arasındaki ilişki değerlendirildiğinde, Bacteroidetes ile Firmicutes yüzdesi arasında istatistiksel olarak yüksek anlamlı ve negatif korelasyon bulunurken (r= -0.778, p< 0.001), Enterobacter ve Bifidobacterium yüzdesi arasında orta derecede istatistiksel anlamlılık ve pozitif korelasyon gözlenmiştir (r= 0.460, p= 0.005). Sonuçlar, bağırsak mikrobiyotasının fibromiyaljide rol oynayabileceğini göstermektedir. Bağırsaktaki Firmicutes ve Bacteroidetes filumlarının dengesinin bağırsak homeostazı için önemli etkilere sahip olduğu bilinmektedir. Özetle, daha büyük kohortlarda yapılacak büyük ölçekli araştırmaların, bağırsak mikrobiyomu ve FMS arasındaki ilişkiyi anlamada ve olası tedavi seçeneklerini değerlendirmede etkili olacağı açıktır.Publication Open Access The Effects of Coronavirus Disease 2019 Outbreak on Medical Students(2021-03-01T00:00:00Z) Bilgi, Kadir; Aytaş, Gamze; Karatoprak, Utku; Kazancıoğlu, Rümeyza; Özçelik, Semra; ÖZÇELİK, SEMRAIntroduction: The coronavirus disease 2019 (Covid-19) pandemic has influenced the whole world, where after the first case was diagnosed in Turkey, educational activities were suspended and partial curfews were implemented. This study was conducted to assess the concerns faced by the medical students about their professional life due to the disrupted educational activities and related psychological effects. Methods: This is a cross-sectional survey study, conducted with self-administered questionnaires on Bezmialem Vakif University medical students, during the pandemic. The questionnaire consists of queries about demographics, environmental factors, Generalized Anxiety Disorder-7 (GAD-7), and Patient Health Questionnaire-9 (PHQ-9) scales. Results: A total of 178 students participated in the study, with a female-to-male ratio of 5:2. Of the total respondents, 19.7% were experiencing severe anxiety, 17.4% moderate anxiety, and 37.1% mild anxiety, according to the GAD-7; and 13.5% of the respondents were experiencing severe depression, 21.9% moderate-severe depression, and 23% mild depression according to the PHQ-9. There was no statistically significant difference between the grades in terms of GAD-7 or PHQ-9 scores. Male participants were more likely to have suicidal thoughts (p = 0.013). According to our study, the factors with the highest influence on students were as follows: "Major changes in personal life," "Disruption in educational activities," and "Covid-19 related anxiety of loss of relatives and contamination or infection." On average, women voted higher points for "Covid-19 related anxiety of loss of relatives and contamination." Conclusions: We found that a significant portion of students regardless of their year in medical school were profoundly affected by the pandemic process as is shown by their anxiety and depression scores. The disruption in educational activities is one of the main factors of these effects, and we believe that these should not be ignored, as they could in the future lead to a series of problems for medical education and students alike.Publication Open Access Evaluation of Community Based Medical Education Program in Bezmialem Vakıf University Faculty of Medicine Education(2020-07-01T00:00:00Z) ÖZÇELİK, SEMRA; ÖZYILDIRIM, BEDİA; Acar, Ceyda; ÖZYILDIRIM, BEDİA; ÖZÇELİK, SEMRAObjective: The World Health Organization, National and international accreditation bodies emphasize that physician candidates should also receive training in environments where they can see and recognize the health problems and health system of the society in which they live. The aim of this study is to evaluate community-based medical education practices in Bezmialem Vakif Faculty of Medicine education program. Methods: Beginning from the first period of our medical education for community based medical education and community recognition program practices; visits to community health centers, family health centers, childrens' houses from social work instutitions, hospice, tuberculosis dispensary, as well as Bezmialem Public Health Days as an education and service project in society and the Forensic Medicine Institute has been planned as application areas. All applications were made in the training program on predetermined dates and the feedbacks received from the students were evaluated using the thematic analysis method. The feedback of each program was evaluated as a separate category and analyzed on the themes of education efficiency, fitness for purpose, adequacy of the organization. Results: The students expressed their satisfaction with these educational activities and community visits to the community. However, they stated that the applications in the pre-clinical period were close to exam dates, problems such as disruptions in transportation, that they wanted to communicate with more people in the institutions they went to and that the applications should be extended for a longer period of time. Conclusion: Physicians need to be aware of the health and social problems of the society in which they live and to be aware of them. It has been determined that the applications of our faculty are well integrated into the educational programs and that many of the knowledge they have gained in theory has strengthened in the application areas in the primary care. Children's Houses and Darulaceze visits have been found to be beneficial for preclinical students in terms of getting to know the community and raising awareness. The students' suggestions were discussed in the relevant boards and reflected in the next year's curriculum.Publication Open Access Evaluation of the Opinions of the First, Second and Third Term Medical Students About Problem Based Learning Sessions in Bezmialem Vakıf University(2020-04-01T00:00:00Z) Korkmaz, Nurten Seda; Özçelik, Semra; ÖZÇELİK, SEMRAObjective: Problem-based learning (PBL) is a student-centered small group study and active learning method. It aims to provide students with the skills of self-learning, learning to learn, and solving real-world problems and is used as a learning method in many medical faculties. In this study, it was aimed to examine and evaluate the perceptions and opinions of Bezmialem Vakif University Faculty of Medicine students about PBL applications and all processes. Methods: For this purpose, a questionnaire consisting of 16 questions was prepared and applied to first, second and third term students in Bezmialem Vakif University Faculty of Medicine. In this questionnaire, students' perceptions and opinions were evaluated with a five-point Likert scale and an open-ended question. Results: According to the results, overall satisfaction was found to be 3.67 on average. These ratios were; 3.85 in the first term students, 3.54 in the second term students, and 3.66 in third term students. As a result, the highest satisfaction was achieved in the proposition "PBL participants are always respectful to the group" with a score of 4.19. The proposition "PBL trainers help to discuss problems in every way" was found to get the lowest score (3.57). The other lowest score (3.59) was achieved in the prosposition "Everyone comes prepared for the second session in PBL sessions". Conclusion: With these data, accurate decisions can be made about which steps should be considered in our practices and the aspects that need to be improved. Our goal is to organize PBL sessions in each committee in the preclinical term.