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SÖNMEZ, ŞİRİN

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ŞİRİN
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SÖNMEZ
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A Rare Case of Neuroblastoma Presenting with Skin Findings

2019-11-01T00:00:00Z, SÖNMEZ, ŞİRİN, Selcuk, Uzuner, BAHALI, ANIL GÜLSEL, ÇAKIR, FATMA BETÜL, Irmak, Tahaoglu, SÖNMEZ, ŞİRİN, BAHALI, ANIL GÜLSEL, ÇAKIR, FATMA BETÜL

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Acute Myocarditis and Eculizumab Caused Severe Cholestasis in a 17-Month-Old Child Who Has Hemolytic Uremic Syndrome Associated with Shiga Toxin-Producing Escherichia coli

2021-09-01T00:00:00Z, YEŞİLBAŞ, Osman, Yozgat, Can Yilmaz, AKINCI, NURVER, SÖNMEZ, ŞİRİN, TEKİN, ESER, TALEBAZADEH, FARAZ, JAFAROV, UZEYİR, OTÇU TEMUR, Hafize, YOZGAT, YILMAZ, YEŞİLBAŞ, OSMAN, AKINCI, NURVER, SÖNMEZ, ŞİRİN, TEKİN, ESER, TALEBAZADEH, FARAZ, JAFAROV, UZEYİR, OTÇU TEMUR, HAFİZE, YOZGAT, YILMAZ

Cardiovascular involvement is uncommon in pediatric patients with hemolytic uremic syndrome associated with Shiga toxin-producing Escherichia coli (STEC-HUS). In this case report we presented a case of 17-month-old toddler who had a sporadic type of STEC-HUS complicated by acute myocarditis. The patient was successfully treated by a single dose of eculizumab after six doses of therapeutic plasma exchange (TPE) were inefficient to prevent the cardiac complication. Hepatotoxicity was observed after a single dose of eculizumab. Hepatic and cholestatic enzyme levels slowly returned to normal within 6 months. To the best of our knowledge, this is the first case of myocarditis/cardiomyopathy treated with eculizumab in STEC-HUS. This case illustrates the need for vigilance regarding myocardial involvement and eculizumab-induced hepatotoxicity in STEC-HUS.