Person: SÜMBÜL, BİLGE
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Publication Metadata only Nasal fluid secretory immunoglobulin A levels in children with allergic rhinitis(2016-04-01T00:00:00Z) Dilek, Fatih; ÖZKAYA, EMİN; Gultepe, Bilge; YAZICI, MEBRURE; Iraz, Meryem; ÖZKAYA, EMİN; SÜMBÜL, BİLGE; YAZICI, MEBRUREObjectives: There is growing knowledge about the immunoregulatory and possibly preventative roles of immunoglobulin A (IgA) in allergic diseases. This study aimed to investigate secretory immunoglobulin A (SIgA) levels in the nasal fluid of children who were either being treated for their allergic rhinitis (AR) with intranasal mometasone furoate or were not receiving treatment.Publication Metadata only Antibiotic resistance patterns of Escherichia Coli strains isolated from urine cultures İdrar kültürlerinden izole edilen Escherichia coli suşlari’nin antibiyotik direnç paterni(2014-01-01) IRAZ, Meryem; Gültepe, BİLGE; CEYLAN, AYŞE NUR; DOYMAZ, MEHMET ZİYA; SÜMBÜL, BİLGE; CEYLAN, AYŞE NUR; DOYMAZ, MEHMET ZIYAPublication Open Access Temporal trends and patterns in antimicrobial-resistant Gram-negative bacteria implicated in intensive care unit-acquired infections: A cohort-based surveillance study in Istanbul, Turkey(2018-09-01) GULTEPE, Bilge; Kritsotakis, Evangelos; Lee, Andrew C. K.; Torun, PERİHAN; Hakyemez, Ismail N.; Aslan, Turan; DURDU, BÜLENT; TORUN, PERİHAN; SÜMBÜL, BİLGEObjectives: This study assessed trends and patterns in antimicrobial-resistant intensive care unit (ICU)-acquired infections caused by Gram-negative bacteria (GNB) in Istanbul, Turkey.Publication Metadata only Prognostic value of procalcitonin in infection-related mortality of cancer patients(2016-05-01) Sedef, Ali Murat; Kose, Fatih; Sumbul, Ahmet Taner; Dogan, Ozlem; Kursun, Ebru; Yurdakul, Zafer; Gultepe, BİLGE; Mertsoylu, Huseyin; Sezer, Ahmet; Ozyilkan, Ozgur; SÜMBÜL, BİLGEPurpose: Infectious diseases are a major cause of morbidity and mortality in cancer patients. Tumor-induced inflammatory responses may increase the value of classical inflammatory markers in blood, so these markers may not be as useful in cancer patients as in non-cancer patients. Serum procalcitonin (PCT) is a sensitive and specific biomarker for severe infection, and has been shown to be unaffected by tumor-induced inflammatory response. In this study we aimed to evaluate the possible role of PCT in mortality in cancer patients with infection.Publication Open Access High prevalence of chronic hepatitis D virus infection in Eastern Turkey: urbanization of the disease(2016-04-01) Dulger, Ahmet Cumhur; Suvak, Burak; Gonullu, Hayriye; GONULLU, Edip; Gultepe, BİLGE; Aydın, İbrahim; Batur, Abdussamet; Karadaş, Sevdegül; Olmezi, Sehmus; SÜMBÜL, BİLGEIntroduction: Both hepatitis B virus (HBV) and hepatitis D virus (HDV) infection play an increasingly important role in liver diseases. The main objective of this study was to investigate the socio-epidemiological, laboratory and radiological aspects of both HBV and HDV infection near the Iranian border of Turkey. Material and methods: The study included 3352 patients with HBV and HDV infection. Socioepidemiological, laboratory and radiological aspects of the study subjects were retrospectively examined. Comorbid metabolic diseases were not assessed due to the retrospective design of the study. Results: Most of the study subjects were HBe antigen negative. No significant difference in terms of HBV-DNA levels or HBe antigen seropositivity was detected between the city centre and rural areas (p > 0.005). The mean HBV-DNA level in the anti-HDV-positive group was significantly lower than in the anti-HDV-negative group (p < 0.001). The rate of HDV-RNA positivity in women was higher than in their male counterparts (p = 0.017). Anti-HDV-IgG was detected in 18.4% of tested subjects who came from an urban area. In contrast, 12.5% of subjects of the rural group had a positive result for anti-HDV-IgG. Among 134 ultrasonographically evaluated delta hepatitis patients, 37.3% had liver cirrhosis. On the other hand, in 1244 patients with hepatitis B monoinfection, there were 90 patients with liver cirrhosis. Radiologically, the rate of hepatic steatosis in delta hepatitis patients was lower than in those with HBV monoinfection. Conclusions: Hepatitis D virus infection was particularly prevalent among the urban population as well as in female subjects. More broadly, the current observations are the first to suggest an inverse correlation between delta hepatitis and ultrasonography-proven hepatic steatosis.Publication Metadata only Doğurganlık Çağındaki Kadınlarda Toksoplazma ve Rubella Seroprevalansı(2015-01-01) IRAZ, MERYEM; GÜLTEPE, BİLGE; CEYLAN, AYŞE NUR; DOYMAZ, MEHMET ZİYA; SÜMBÜL, BİLGE; CEYLAN, AYŞE NUR; DOYMAZ, MEHMET ZIYAPublication Metadata only Perforated appendicitis in children: antimicrobial susceptibility and antimicrobial stewardship(2018-09-01) TÜREL, ÖZDEN; MİRAPOĞLU, SEMİH LÜTFİ; GÜLTEPE, BİLGE; TÜREL, ÖZDEN; MİRAPOĞLU, SEMİH LÜTFİ; SÜMBÜL, BİLGEPublication Metadata only HBsAg, Anti-HBs and Anti-HCV Seroprevalence of the Patients Applied to the Medical Faculty of Bezmialem Foundation University(2013-12-01T00:00:00Z) Iraz, Meryem; Gultepe, Bilge; DOYMAZ, Mehmet Ziya; SÜMBÜL, BİLGE; DOYMAZ, MEHMET ZIYAObjective: The infections caused by hepatitis B and hepatitis C virus are still remain one of most important health problems for our country. The purpose of this study was to determine the frequency of HBsAg, anti-HBs and anti-HCV positivity in the patients who were admitted to the Research Hospital of the Medical Faculty of Bezmialem Vakif University between November 2011 and May 2013.Publication Open Access The relationship between serum histon levels and the severity of acute pancreatitis.(2019-09-01) Biberci, Keskin; Şentürk, H; Köker, İH; Sümbül, Gültepe; İnce, AT; İNCE, ALİ TÜZÜN; SÜMBÜL, BİLGE; ŞENTÜRK, HAKANBackground/Aims: Despite various scoring systems and imaging methods, it is hard to predict the severity and the course of acute pancreatitis (AP), thereby necessitating better and more reliable markers. Since inflammation plays a key role in the pathogenesis of AP, we sought to determine whether histone, which is a novel inflammatory marker, may play a role in the prediction of severity and prognosis. Materials and Methods: A total of 88 consecutive adult patients (>18 years) with a first AP episode were prospectively enrolled in the study. Severe AP was defined as having a revised Atlanta score >3 in the first 48 h after admission. Circulating histone 3 and 4 levels were measured using the enzyme-linked immunosorbent assay method. Results: Eighty-eight consecutive adult patients with a first episode of AP were divided into two groups according to severity, in which 56 (63.6%) were assigned to the mild AP group and 32 (36.4%) to the severe AP group. White blood cell, hemoglobin, creatinine, and aspartate aminotransferase levels were significantly higher in the severe AP group. However, there was no difference in serum histone levels between the groups, and there was no correlation between revised Atlanta score and serum histone levels either. Conclusion: Serum histone levels did not significantly differ between the severe and mild AP groups. Therefore, these markers may not provide additional benefit for determining the severity of AP.Publication Metadata only Evaluation of nasal fluid beta-defensin 2 levels in children with allergic rhinitis(2017-06-01) DILEK, Fatih; EMIN, Ozkaya; Gultepe, BİLGE; Yazici, MEBRURE; Cakir, ERKAN; GEDIK, Ahmet Hakan; SÜMBÜL, BİLGE; YAZICI, MEBRURE; ÇAKIR, ERKANAim: Knowledge about the role of the innate immune system in the pathogenesis of allergic diseases has been expanding in recent years. Defensins are antimicrobial peptides that are components of the innate immune system. Defensins have strong efficacy against bacterial, viral, and fungal infections. Moreover, they have regulatory functions in many physiologic processes such as antitumoral immunity, chemotaxis, inflammation, and wound healing. In this study, we aimed to investigate a-defensin 2 levels in the nasal fluids of children with allergic rhinitis.