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SÜMBÜL, BİLGE

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BİLGE
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SÜMBÜL
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End date: 2022 × Start date: 2020 × Item Type: Publication × Type: Article × Subject: Antibody titers ×

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    PublicationOpen Access
    Is there a link between pre-existing antibodies acquired due to childhood vaccinations or past infections and COVID-19? A case control study
    (2021-02-01T00:00:00Z) SÜMBÜL, BİLGE; Sumbul, Hilmi Erdem; OKYAY, RAMAZAN AZİM; Gulumsek, Erdinc; ŞAHİN, AHMET RIZA; Boral, Baris; Kocyigit, Burhan Fatih; Alfishawy, Mostafa; Gold, Jeffrey; Tasdogan, Ali Muhittin; SÜMBÜL, BİLGE
    Background: There is growing evidence indicating that children are less affected from COVID-19. Some authors speculate that childhood vaccinations may provide some cross-protection against COVID-19. In this study, our aim was to compare the circulating antibody titers for multiple childhood vaccine antigens, as an indicator of the state of immune memory between patients with COVID-19 and healthy controls, with a specific aim to identify the association between disease severity and antibody titrations which may indicate a protective function related to vaccine or disease induced memory. Methods: This study is a case-control study including 53 patients with COVID-19 and 40 healthy volunteers. COVID-19 severity was divided into three groups: asymptomatic, mild and severe. We measured the same set of antibody titers for vaccine antigens, and a set of biochemical and infection markers, in both the case and control groups. Results: Rubella (p = 0.003), pneumococcus (p = 0.002), and Bordetella pertussis (p < 0.0001) titers were found to be significantly lower in the case group than the control group. There was a significant decline in pneumococcus titers with severity of disease (p = 0.021) and a significant association with disease severity for Bordetella pertussis titers (p = 0.014) among COVID patients. Levels of AST, procalcitonin, ferritin and D-dimer significantly increased with the disease severity. Discussion: Our study supports the hypothesis that pre-existing immune memory, as monitored using circulating antibodies, acquired from childhood vaccinations, or past infections confer some protection against COVID-19. Randomized controlled studies are needed to support a definitive conclusion