Person: SÜMBÜL, BİLGE
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Publication Isolated from Perineal Abscess Actinomyces neuii subsp. neuii Case Report(2019-03-01) Akbaş, Emel; SÜMBÜL GÜLTEPE, BİLGE; Ersöz, Cevper; Ceylan, Ayşenur; Doymaz, Mehmet Ziya; SÜMBÜL, BİLGE; DOYMAZ, MEHMET ZIYAPublication Perfore apandisit: Etkenlerin ve enfeksiyon belirteçlerinin klinik iyileşme ve antibiyotik seçimine etkisi(2017-10-28) MIRAPOGLU, S. L.; AYDOĞDU, İBRAHİM; TÜREL, ÖZDEN; ÇAY, ALİ; GÜLTEPE, BİLGE; AYDOĞDU, İBRAHİM; TÜREL, ÖZDEN; ÇAY, ALI; SÜMBÜL, BİLGEPublication Nasal fluid secretory immunoglobulin A levels in children with allergic rhinitis(2016-04-01T00:00:00Z) Dilek, Fatih; ÖZKAYA, EMİN; Gultepe, Bilge; YAZICI, MEBRURE; Iraz, Meryem; ÖZKAYA, EMİN; SÜMBÜL, BİLGE; YAZICI, MEBRUREObjectives: There is growing knowledge about the immunoregulatory and possibly preventative roles of immunoglobulin A (IgA) in allergic diseases. This study aimed to investigate secretory immunoglobulin A (SIgA) levels in the nasal fluid of children who were either being treated for their allergic rhinitis (AR) with intranasal mometasone furoate or were not receiving treatment.Publication Antibiotic resistance patterns of Escherichia Coli strains isolated from urine cultures İdrar kültürlerinden izole edilen Escherichia coli suşlari’nin antibiyotik direnç paterni(2014-01-01) IRAZ, Meryem; Gültepe, BİLGE; CEYLAN, AYŞE NUR; DOYMAZ, MEHMET ZİYA; SÜMBÜL, BİLGE; CEYLAN, AYŞE NUR; DOYMAZ, MEHMET ZIYAPublication Koneman Renkli Atlas ve Tanısal Mikrobiyoloji Kitabı(2017-01-01) GÜLTEPE, BİLGE; SÜMBÜL, BİLGEPublication İDRAR KÜLTÜRLERİNDEN İZOLE EDİLEN ESCHERİCHİA COLİ SUŞLARI’NIN ANTİBİYOTİK DİRENÇ PATERNİ(2014-09-03) IRAZ M.; SÜMBÜL B.; CEYLAN A. N.; DOYMAZ M. Z.; SÜMBÜL, BİLGE; DOYMAZ, MEHMET ZIYAPublication Results of nucleos(t)ide analog treatment discontinuation in hepatitis b e-Antigen-negative chronic hepatitis b: Nucstop study(2024-01-01) Kiremitci S.; Kochan K.; SEVEN G.; Keskin E. B.; OKAY G.; AKKOYUNLU Y.; Koc M. M.; SÜMBÜL B.; ŞENTÜRK H.; KİREMİTÇİ, SERCAN; KOÇHAN, KORAY; SEVEN, GÜLSEREN; OKAY, GÜLAY; AKKOYUNLU, YASEMİN; SÜMBÜL, BİLGE; ŞENTÜRK, HAKANBackground/Aims: This study aims to investigate the effects of nucleos(t)ide analogs (NAs) discontinuation in eligible patients in accordance with the Asian Pacific Association for the Study of the Liver hepatitis B guideline and the factors affecting clinical and virological relapses. Materials and Methods: In this prospectively designed study, hepatitis B e antigen (HBeAg)-negative chronic hepatitis B patients who were followed up between 2012 and 2019 were evaluated and 57 patients were included. All participants enrolled the study were HBeAgnegative status at NA initiation. Results: The median age of the patients was 49 (29-72) years and 24 (42%) were females. The median treatment duration was 96 (36-276) months and patients were followed for a median duration of 27 months. Sixteen patients had a previous history of NA switch, and thirteen of these patients had a history of lamivudine resistance. Thirty-eight of 57 patients (66%) developed an elevated hepatitis B virus deoxyribonucleic acid level of 2000 IU/mL at least once, defined as virological relapse and 23 (60%) of them, experienced clinical relapse. Thirty-one of 57 patients were re-Treated during the follow-up, and hepatitis B surface antigen (HBsAg) loss occurred among 4 (7%) patients. All patients who experienced HBsAg loss had a history of lamivudine resistance (P = .002). Conclusion: Despite receiving NAs suppression therapy for a long time, HBsAg loss occurs rarely. Although it was not life-Threatening, most patients experienced relapses and treatment should be restarted. In our study, whether it is a coincidence that all patients with HBsAg loss are patients in whom NAs are used sequentially due to lamivudine resistance is an issue that needs to be further investigated.Publication Discordance between Serum Neutralizing Antibody Titers and the Recovery from COVID-19(2020-09-25T00:00:00Z) Koç, Mm; Kalkan, Yazıcı; Çetin, Nesibe Selma; Doymaz, Mz; Sümbül, B; Durdu, B; YAZICI, MERVE; MERİÇ KOÇ, MELİHA; ÇETİN, NESİBE SELMA; KARAASLAN, ELİF; OKAY, GÜLAY; DURDU, BÜLENT; SÜMBÜL, BİLGE; DOYMAZ, MEHMET ZIYAThe recent pandemic of COVID-19 has caused a tremendous alarm around the world. Details of the infection process in the host have significant bearings on both recovery from the disease and on the correlates of the protection from the future exposures. One of these factors is the presence and titers of neutralizing Abs (NAbs) in infected people. In the current study, we set out to investigate NAbs in the recovered subjects discharged from the hospital in full health. Serum samples from a total of 49 documented consecutive COVID-19 subjects were included in the study. All the subjects were adults, and serum samples collected during the discharge were tested in viral neutralization, enzyme immunoassay (EIA), and Western immunoblot tests against viral Ags. Even though a majority of the recovered subjects had raised significant NAb titers, there is a substantial number of recovered patients (10 out of 49) with no or low titers of NAbs against the virus. In these cohorts as well as in patients with high NAb titers, viral Ag binding Abs were detectable in EIA tests. Both NAb titers and EIA detectable Abs are increased in patients experiencing a severe form of the disease, and in older patients the Ab titers were heightened. The main conclusion is that the recovery from SARS-CoV-2 infection is not solely dependent on high NAb titers in affected subjects, and this recovery process is probably produced by a complex interplay between many factors, including immune response, age of the subjects, and viral pathology.Publication Kistik fibrozis dışı bronşektazide bronkoskop, mikrobiyoloji ve radyoloji ilişkisi(2017-04-09) ÇAKIR, ERKAN; Atabek, Ayşe Ayzıt; DASKAYA, HAYRETTİN; GEDIK, AH; Bilgin, Şennur; ıraz, meryem; GULTEPE, B; UMUTOGLU, T; ÇAKIR, ERKAN; DAŞKAYA, HAYRETTİN; SÜMBÜL, BİLGEPublication Temporal trends and patterns in antimicrobial-resistant Gram-negative bacteria implicated in intensive care unit-acquired infections: A cohort-based surveillance study in Istanbul, Turkey(2018-09-01) GULTEPE, Bilge; Kritsotakis, Evangelos; Lee, Andrew C. K.; Torun, PERİHAN; Hakyemez, Ismail N.; Aslan, Turan; DURDU, BÜLENT; TORUN, PERİHAN; SÜMBÜL, BİLGEObjectives: This study assessed trends and patterns in antimicrobial-resistant intensive care unit (ICU)-acquired infections caused by Gram-negative bacteria (GNB) in Istanbul, Turkey.