Person: DAĞ, AYDAN
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Publication Metadata only Synthesis of New Oleanane Triterpenoids Including Fatty Acids Esters and Investigation of Their in vitro Cytotoxic Effects on 3T3 Fibroblast and PC3 Prostate Cancer Cell Lines(2019-12-19) Dağ, Aydan; Topçu, Gülaçtı; Atasoy, Sezen; Aktaş, Asude Sena; Şenol, Halil; ŞENOL, HALIL; DAĞ, AYDAN; ATASOY, SEZEN; TOPÇU, GÜLAÇTIPublication Metadata only Preclinical studies evaluating the therapeutic efficacy of novel natural compound olean-12-en-28-ol, 3β pentacosanoate for multiple sclerosis(2022-09-26) Şenol H.; Özgün-Acar Ö.; Dağ A.; Eken A.; Acar B.; Aktaş Pepe N.; Güner H.; Aykut Z. G.; Çevik Kaplan S.; Ayaz Güner Ş.; et al.; ŞENOL, HALIL; DAĞ, AYDAN; TOPÇU, GÜLAÇTIPublication Metadata only Synthesis and Comprehensive in Vivo Activity Profiling of Olean-12-en-28-ol, 3β-Pentacosanoate in Experimental Autoimmune Encephalomyelitis: A Natural Remyelinating and Anti-Inflammatory Agent(2023-01-01) Şenol H.; Özgün Acar Ö.; Dağ A.; Eken A.; Güner H.; Aykut Z. G.; Topçu G.; Şen A.; ŞENOL, HALIL; DAĞ, AYDAN; TOPÇU, GÜLAÇTIPublication Open Access Cytotoxic, Apoptotic and Genotoxic Effects of Lipid-Based and Polymeric Nano Micelles, an In Vitro Evaluation(2017-11-01) BAHADORİ, FATEMEH; KOÇYİĞİT, ABDÜRRAHİM; DAĞ, AYDAN; TOPÇU, GÜLAÇTI; BAHADORİ, FATEMEH; KOÇYİĞİT, ABDÜRRAHİM; DAĞ, AYDAN; TOPÇU, GÜLAÇTISelf-assembly systems (SAS) mainly consist of micelles, and liposomes are the classes of Nano Drug Delivery Systems with superior properties compared to traditional therapeutics in targeting cancer tumors. All commercially available nano-formulations of chemotherapeutics currently consist of SAS. According to our knowledge, a specific toxicity comparison based on material differences has not yet been performed. The purpose of this study was to evaluate and compare the toxicity of two SAS consisting of Sterically Stabilized Micelles (SSM) made of a lipid-based amphiphilic distearoyl-sn-glycero-phosphatidylethanolamine-polyethylene glycol (PEG)-2000 and a polymeric micelle (PM) consisting of Y-shape amphiphilic block copolymer, synthesized using poly ε-caprolactone and PEG. The mechanism of cytotoxicity and genotoxicity of micelles on L-929 healthy mouse fibroblast cells was assessed using Sulforhodamine-B, WST-1, Acridine Orange/Ethidium Bromide and alkaline single-cell gel electrophoresis assays. Results showed that SSM in conc. of 40 mg/mL shows very low cytotoxicity at the end of 24, 48 and 72 h. The DNA damage caused by SSM was much lower than PM while the latter one showed significant toxicity by causing apoptosis with the ED50 value of 3 mg/mL. While the DNA damage caused by SSM was ignorable, some DNA chain breaks were detected on cells treated with PM.Publication Metadata only Synthesis and initial evaluation of efficacy of olean-12-en-28-ol, 3 beta-pentacosanoate for the symptomatic treatment of multiple sclerosis(2019-07-01) DAĞ, AYDAN; Sen, A.; ŞENOL, HALİL; Kale, E.; TOPÇU, GÜLAÇTI; ŞENOL, HALIL; DAĞ, AYDAN; TOPÇU, GÜLAÇTIPublication Metadata only Synthesis of New Ursane Triterpenoids Including Fatty Acids Esters and Investigation of Their in vitro Cytotoxic Effects on 3T3 Fibroblast and PC3 Prostate Cancer Cell Lines(2019-12-19) Dağ, Aydan; Topçu, Gülaçtı; Atasoy, Sezen; Çokuludağ, Kübra; Şenol, Halil; ŞENOL, HALIL; DAĞ, AYDAN; ATASOY, SEZEN; TOPÇU, GÜLAÇTI