Person: ATASOY, SEZEN
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ATASOY
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SEZEN
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- PublicationMetadata onlySynthesis of New 4-Thiazolidinone Derivatives and Investigation of their in vitro Cytotoxic Effects on Breast Cancer(2019-12-19) Şenol, Halil; Atasoy, Sezen; Güzeldemirci, Nuray; ŞENOL, HALIL; ATASOY, SEZEN
- PublicationMetadata onlyPhthalocyanine-Conjugated Glyconanoparticles for Chemo-photodynamic Combination Therapy(2021-02-01T00:00:00Z) Dağ, Aydan; Cakilkaya, Eda; Omurtag Özgen, Pınar Sinem; Atasoy, Sezen; Yiğit Erdem, Gulsah; Çetin, Büşra; Gürek, Ayşe Gül; DAĞ, AYDAN; ATASOY, SEZEN
- PublicationOpen AccessA Preliminary Investigation on the Chromosome Aberrations in Acute Lymphoblastic Leukaemia Using Multiprobe Fluorescence In Situ Hybridization Panel(2022-06-01T00:00:00Z) Gokkaya, Bengisu; Atasoy, Sezen; ÇIRAKOĞLU, AYŞE; ARGÜDEN, YELDA; KURU, RAHİYE DİLHAN; YILMAZ, ŞÜKRİYE; ÖNGÖREN, ŞENİZ; DEVİREN, AYHAN; ATASOY, SEZENObjective: Acute lymphoblastic leukemia (ALL) is a disease related to the overproduction of immature lymphocytes. For diagnosis and classification of ALL, recognizing chromosome aberrations using conventional cytogenetic analysis (CCA) is essential. However, limited ability of CCA to capture cryptical chromosomal aberrations is a major drawback. The aim of this study was to investigate recurrent aberrations in patients with ALL with normal karyotype or unsuccessful karyotyping using the fluorescence in situ hybridization (FISH) method. Methods: Ten patients with ALL were included in this study. CCA was done according to the standart protocols, and then, multiprobe FISH panel was used for analyzing different chromosomal regions located on 12p13.2/21q22.12, 9q34.11-q34.12/22q11.22-q11.23, 9p21.3, 19p13.3, 11q23.3, 8q24.21, 14q32.33, 10p11.1-q11.1, 17p11.1-q11.1 and 4q12. Results: Analyses of the specific chromosomal regions with FISH assay revealed undetected chromosome rearrangements. Among all the cases, four of them harbored chromosomal abnormalities. MYC, TCF3, IGH rearrangements, CDKN2A deletion and hyperdiploidy were detected in the study Conclusion: Diagnostic sensitivity of FISH probes in comparison with CCA is effective in the detection of multiple chromosomal rearrangements with prognostic significance. For the improvement of the cytogenetic examination and achieving optimum results for patients with ALL , FISH panels are needed to be used combining with conventional cytogenetics routinely.
- PublicationMetadata onlyInvestigation of cytotoxicity of sealant used in guided bone regeneration(2019-09-08T00:00:00Z) DOGANAY, ÖZGE; ALKAN, ALPER; DİKER, NURETTİN; ATASOY, SEZEN; DOĞANAY, ÖZGE; ATASOY, SEZEN; DİKER, NURETTİN; ALKAN, ALPER
- PublicationMetadata onlyDetection of chromosome aberrations by fluorescence in situ hybridization went unnoticed with the use of conventional cytogenetics in acute lymphoblastic leukaemia(2019-09-07) ATASOY, SEZEN; Gökkaya, Bengisu; ÇIRAKOĞLU, AYŞE; KURU, RAHİYE DİLHAN; DEVİREN, AYHAN; ATASOY, SEZEN
- PublicationMetadata onlySynthesis of new fatty acid derivatives of oleanane and ursane triterpenoids and investigation of their in vitro cytotoxic effects on 3T3 fibroblast and PC3 prostate cancer cell lines(2020-09-01T00:00:00Z) Şenol, Halil; Çokuludağ, Kübra; Aktaş, Asude Sena; Atasoy, Sezen; Dağ, Aydan; Topçu, Gülaçtı; ŞENOL, HALIL; ATASOY, SEZEN; DAĞ, AYDAN; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyGC-MS and LC-MS Analyses of a Brown Algae Cladostephus spongiosus Extracts with Bioactivity Studies(2021-12-08T00:00:00Z) Atasoy, Sezen; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; ATASOY, SEZEN; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyAnalysis of Chromosome 3, 7 and 8 Centromeric Regions in Bronchial Lavage Specimens by FISH(2016-10-01T00:00:00Z) Atasoy, Sezen; Erturan, Salih Serdar; Yilmaz, Nail; Kuru, Dilhan; Cirakoglu, Ayse; Yilmaz, Sukriye; Deviren, Ayhan; ATASOY, SEZENOBJECTIVES: Multiple genetic changes are observed in malignant tumors but are rare or absent in benign conditions. Aneuploidy is the most common feature of solid tumors including lung cancer and diagnosis of malignant tumors is possible through detection of aneuploidy. The aim of this study was to investigate chromosomal abnormalities in cells from non-small cell lung cancer patients obtained bronchoscopically and to evaluate the suitability of fluorescence in situ hybridization (FISH).
- PublicationMetadata onlyGlycopolymer decorated multiwalled carbon nanotubes for dual targeted breast cancer therapy.(2020-03-25T00:00:00Z) Omurtag Ozgen, Pinar Sinem; Zengin Kurt, Belma; Durmus, Zehra; Yigit, Gülşah; Dağ, Aydan; ATASOY, SEZEN; ZENGİN KURT, BELMA; DAĞ, AYDANCarbon-based nanomaterials (CNMs) have attracted great attention in biomedical applications such as cancer imaging and therapy. CNMs, which are currently used in a wide range of applications, suffer from drawbacks of toxicity and low biocompatibility. Either noncovalent or covalent functionalization of CNMs with hydrophilic and biocompatible polymers which help to block hydrophobic interactivity between CNMs and cells can greatly increase their biocompatibility by eliminating their probable toxicity towards living organisms. In this report, we present a comparison of both noncovalent and covalent functionalization approaches in order to introduce a biocompatible glycoblock copolymer onto multi-walled carbon nanotubes (CNTs) in order to enhance their potential in therapies. An anticancer drug (doxorubicin, Dox) was conjugated with two different end functionalized poly(1-O-methacryloyl-beta-d-fructopyranose-b-(2-methacryloxyethoxy))benzaldehyde glycoblock copolymers, which were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, by either noncovalent or covalent tethering. CNTs were coated separately with the synthesized drug-conjugated glycoblock copolymers and folic acid (FA) to obtain an efficient drug delivery platform for dual-targeting of glucose transporter protein (GLUT5) and folic acid receptors (FR) in breast cancer. A library of synthesized monomers, polymers and prepared glycoblock copolymer coated CNTs (hybrid-CNTs) using both approaches were comprehensively characterized by various techniques. Transmission electron microscopy measurements showed the homogeneous, smooth morphology of the prepared Dox-conjugated glycoblock copolymer coating of CNTs and confocal laser scanning microscopy images displayed successful cellular internalization of hybrid-CNTs in the MCF-7 and MDA-MB-231 human breast cancer cell lines. This research demonstrates the potential of hybrid-CNTs as a biocompatible drug delivery system as well as in vitro use of Dox-conjugated vehicles for dual receptor mediated breast cancer therapy.
- PublicationMetadata onlyEvaluation of cytotoxic and antioxidant potential of Dittrichia viscosa (L.) Greuter used in traditional medicine(2021-08-01T00:00:00Z) SEVGİ, ECE; DAĞ, AYDAN; Kizilarslan-Hancer, Cagla; ATASOY, SEZEN; ZENGİN KURT, BELMA; Aksakal, Oznur; SEVGİ, ECE; DAĞ, AYDAN; KIZILARSLAN HANÇER, ÇAĞLA; ATASOY, SEZEN; ZENGİN KURT, BELMAEthnopharmacological relevance: Dittrichia viscosa (L.) Greuter (& ldquo;Sari ot, Yapis & cedil;kan andiz otu & rdquo; in Turkish) is a medicinal plant that has been traditionally used in the Mediterranean area. This plant is used by the local population for the treatment of cancer. Investigation of their biological activities is therefore very important to be supported by scientific basis for traditional use.
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